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The Journal of Neuroscience, 2001, 21:RC158:1-4

RAPID COMMUNICATION
Spatial Distribution of Low- and High-Voltage-Activated Calcium Currents in Neurons of the Deep Cerebellar Nuclei

Volker Gauck2, Michael Thomann1, Dieter Jaeger2, and Alexander Borst1

1 Friedrich-Miescher-Laboratory of the Max-Planck-Society, 72076 Tuebingen, Germany, and 2 Department of Biology, Emory University, Atlanta, Georgia 30322

The spatial distribution of low-voltage-activated (LVA) and high-voltage-activated (HVA) barium currents was investigated in neurons of the deep cerebellar nuclei (DCN) by combining barium imaging with voltage clamp. The current-induced fluorescence signal (Delta F/F) of the HVA current was five times higher then the LVA-induced signal at the soma, but both signals were approximately equal in size in distant dendrites. This position-dependent shift of Delta F/F indicates a non-uniform distribution of the underlying calcium channels. The higher weight of the LVA signal in the dendrites suggests that the LVA might be of particular relevance for the dendritic integration of synaptic inputs.

Key words: calcium imaging; low-voltage-activated calcium current; high-voltage-activated calcium current; dendritic integration; subcellular compartmentalization; cerebellar nuclei

Copyright © Society for Neuroscience  0270-6474//$05.00/0




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