QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (44) Citing Articles via Google Scholar Google Scholar Articles by Thiel, C. M. Articles by Dolan, R. J. Search for Related Content PubMed PubMed Citation Articles by Thiel, C. M. Articles by Dolan, R. J. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB SCOPOLAMINE

 Previous Article  |  Next Article 

The Journal of Neuroscience, September 1, 2001, 21(17):6846-6852

Pharmacological Modulation of Behavioral and Neuronal Correlates of Repetition Priming

Christiane M. Thiel¹, Richard N. A. Henson^{1, 2}, John S. Morris¹, Karl J. Friston¹, and Raymond J. Dolan^{1, 3}

¹ Wellcome Department of Cognitive Neurology, Institute of Neurology, London, WC1 3BG, United Kingdom, ² Institute of Cognitive Neuroscience, University College London, London WC1 3BG, United Kingdom, and ³ Royal Free Hospital School of Medicine, London NW3 2PF, United Kingdom

In this experiment we address the pharmacological modulation of repetition priming, a basic form of learning, using event-related functional magnetic resonance imaging. We measured brain activity in a word-stem completion paradigm in which, before study, volunteers were given either placebo, lorazepam (2 mg orally), or scopolamine (0.4 mg, i.v.). Relative to placebo, both drugs attenuated the behavioral expression of priming. Repetition was associated with a decreased neuronal response in left extrastriate, left middle frontal, and left inferior frontal cortices in the placebo group. Both drugs abolished these "repetition suppression" effects. By showing a concurrence of behavioral and neuronal modulations, the results suggest that GABAergic and cholinergic systems influence the neuronal plasticity necessary for repetition priming.

Key words: fMRI; priming; scopolamine; lorazepam; psychopharmacology; neuroimaging; word-stem completion; repetition suppression

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/21176846-07$05.00/0

This article has been cited by other articles:

				N. Lange What can modern statistics offer imaging neuroscience? Statistical Methods in Medical Research, October 1, 2003; 12(5): 447 - 469. [Abstract] [PDF]

				E. L. Grigorenko The first candidate gene for dyslexia: Turning the page of a new chapter of research PNAS, September 30, 2003; 100(20): 11190 - 11192. [Full Text] [PDF]

				P. Bentley, P. Vuilleumier, C. M. Thiel, J. Driver, and R. J. Dolan Effects of Attention and Emotion on Repetition Priming and Their Modulation by Cholinergic Enhancement J Neurophysiol, August 1, 2003; 90(2): 1171 - 1181. [Abstract] [Full Text] [PDF]

				E. Bullmore, J. Suckling, F. Zelaya, C. Long, G. Honey, L. Reed, C. Routledge, V. Ng, P. Fletcher, J. Brown, et al. Practice and Difficulty Evoke Anatomically and Pharmacologically Dissociable Brain Activation Dynamics Cereb Cortex, February 1, 2003; 13(2): 144 - 154. [Abstract] [Full Text] [PDF]

				O. Donchin, L. Sawaki, G. Madupu, L. G. Cohen, and R. Shadmehr Mechanisms Influencing Acquisition and Recall of Motor Memories J Neurophysiol, October 1, 2002; 88(4): 2114 - 2123. [Abstract] [Full Text] [PDF]

				R. Sperling, D. Greve, A. Dale, R. Killiany, J. Holmes, H. D. Rosas, A. Cocchiarella, P. Firth, B. Rosen, S. Lake, et al. Functional MRI detection of pharmacologically induced memory impairment PNAS, December 21, 2001; (2001) 12467899. [Abstract] [Full Text] [PDF]

				R. Sperling, D. Greve, A. Dale, R. Killiany, J. Holmes, H. D. Rosas, A. Cocchiarella, P. Firth, B. Rosen, S. Lake, et al. Functional MRI detection of pharmacologically induced memory impairment PNAS, January 8, 2002; 99(1): 455 - 460. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help