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The Journal of Neuroscience, September 15, 2001, 21(18):7063-7068

Secretin Facilitates GABA Transmission in the Cerebellum

Wing-Ho Yung¹, Po-Sing Leung¹, Samuel S. M. Ng², Jie Zhang¹, Savio C. Y. Chan¹, and Billy K. C. Chow²

¹ Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong, and ² Department of Zoology, University of Hong Kong, Pokfulam, Hong Kong

Secretin was the first hormone discovered in human history, and yet, its function as a neuropeptide has been overlooked in the past. The recent discovery of the potential use of secretin in treating autistic patients, together with the conflicting reports on its effectiveness, urges an in-depth investigation of this issue. We show here that in the rat cerebellar cortex, mRNAs encoding secretin are localized in the Purkinje cells, whereas those of its receptor are found in both Purkinje cells and GABAergic interneurons. Immunoreactivity for secretin is localized in the soma and dendrites of Purkinje cells. In addition, secretin facilitates evoked, spontaneous, and miniature IPSCs recorded from Purkinje cells. We propose that secretin is released from the somatodendritic region of Purkinje cells and serves as a retrograde messenger modulating GABAergic afferent activity.

Key words: secretin; cerebellum; Purkinje cells; GABA; inhibitory postsynaptic currents; autism

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Copyright © 2001 Society for Neuroscience  0270-6474/01/21187063-06$05.00/0

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