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Previous Article | Next Article
The Journal of Neuroscience, September 15, 2001, 21(18):7153-7160
Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus
Bettina Seri1, Jose Manuel García-Verdugo2, Bruce S. McEwen1, and Arturo Alvarez-Buylla3 1 The Rockefeller University, New York, New York 10021, 2 University of Valencia, Burjasot-46100, Valencia, Spain, and 3 University of California, San Francisco, San Francisco, California 94143-0520
Neurogenesis in the dentate gyrus of the hippocampus persists throughout life in many vertebrates, including humans. The progenitors of these new neurons reside in the subgranular layer (SGL) of the dentate gyrus. Although stem cells that can self-renew and generate new neurons and glia have been cultured from the adult mammalian hippocampus, the in vivo primary precursors for the formation of new neurons have not been identified. Here we show that SGL cells, which express glial fibrillary acidic protein and have the characteristics of astrocytes, divide and generate new neurons under normal conditions or after the chemical removal of actively dividing cells. We also describe a population of small electron-dense SGL cells, which we call type D cells and are derived from the astrocytes and probably function as a transient precursor in the formation of new neurons. These results reveal the origins of new neurons in the adult hippocampus.
Key words: neurogenesis; hippocampus; neural stem cells; astrocytes; adult mammalian brain; dentate gyrus; subgranular layer
Copyright © 2001 Society for Neuroscience 0270-6474/01/21187153-08$05.00/0
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S. C. Noctor, A. C. Flint, T. A. Weissman, W. S. Wong, B. K. Clinton, and A. R. Kriegstein
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J. Neurosci., April 15, 2002; 22(8): 3161 - 3173.
[Abstract] [Full Text] [PDF]
R. M. Seaberg and D. van der Kooy
Adult Rodent Neurogenic Regions: The Ventricular Subependyma Contains Neural Stem Cells, But the Dentate Gyrus Contains Restricted Progenitors
J. Neurosci., March 1, 2002; 22(5): 1784 - 1793.
[Abstract] [Full Text] [PDF]
The NeuroscientistComments
Neuroscientist, February 1, 2002; 8(1): 1 - 2.
[PDF]
E. Gould and C. G. Gross
Neurogenesis in Adult Mammals: Some Progress and Problems
J. Neurosci., February 1, 2002; 22(3): 619 - 623.
[Full Text] [PDF]
A. Alvarez-Buylla and J. M. Garcia-Verdugo
Neurogenesis in Adult Subventricular Zone
J. Neurosci., February 1, 2002; 22(3): 629 - 634.
[Full Text] [PDF]
A. Gritti, L. Bonfanti, F. Doetsch, I. Caille, A. Alvarez-Buylla, D. A. Lim, R. Galli, J. M. G. Verdugo, D. G. Herrera, and A. L. Vescovi
Multipotent Neural Stem Cells Reside into the Rostral Extension and Olfactory Bulb of Adult Rodents
J. Neurosci., January 15, 2002; 22(2): 437 - 445.
[Abstract] [Full Text] [PDF]
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