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Previous Article | Next Article
The Journal of Neuroscience, September 15, 2001, 21(18):7303-7312
Iontophoresis In Vivo Demonstrates a Key Role for GABAA and Glycinergic Inhibition in Shaping Frequency Response Areas in the Inferior Colliculus of Guinea Pig
Fiona E. N. LeBeau1, 2, Manuel S. Malmierca1, 3, and Adrian Rees1 1 Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom, 2 School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom, and 3 Laboratory for the Neurobiology of Hearing, Institute of Neuroscience of Castilla y León, University of Salamanca, 37007 Salamanca, Spain
The processing of biologically important sounds depends on the analysis of their frequency content by the cochlea and the CNS. GABAergic inhibition in the inferior colliculus shapes frequency response areas in echolocating bats, but a similar role in nonspecialized mammals has been questioned. We used the powerful combination of iontophoresis with detailed analysis of frequency response areas to test the hypothesis that GABAergic and glycinergic inhibition operating in the inferior colliculus of a nonspecialized mammal (guinea pig) shape the frequency responses of neurons in this nucleus. Our analysis reveals two groups of response areas in the inferior colliculus: V-shaped and non-V-shaped. The response as a function of level in neurons with V-shaped response areas can be either monotonic or nonmonotonic. Application of bicuculline or strychnine in these neurons, to block inhibition mediated by GABAA or glycinergic receptors, respectively, increases firing rate primarily within the boundaries of the control response area. In contrast, neurons in the non-V-shaped group have response areas that include narrow, closed, tilted, and double-peaked types. In this group, blockade of GABAA and glycine receptors increases firing rate but also changes response area shape, with most becoming more V-shaped. We conclude that (1) non-V-shaped response areas can be generated by GABA and glycinergic synapses within the inferior colliculus and do not simply reflect inhibition acting more peripherally in the pathway and (2) frequency-dependent inhibition is an important general feature of the mammalian inferior colliculus and not a specialization unique to echolocating bats.
Key words: inhibitory neurotransmitters; inhibition; auditory system; microiontophoresis; inferior colliculus; frequency response area; GABA; glycine; guinea pig
Copyright © 2001 Society for Neuroscience 0270-6474/01/21187303-10$05.00/0
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