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The Journal of Neuroscience, September 15, 2001, 21(18):7323-7330

The Conjoint Importance of the Hippocampus and Anterior Thalamic Nuclei for Allocentric Spatial Learning: Evidence from a Disconnection Study in the Rat

E. Clea Warburton, Alison Baird, Angela Morgan, Janice L. Muir, and John P. Aggleton

School of Psychology, University of Cardiff, Wales CF10 3YG, United Kingdom

A disconnection procedure was used to test whether the hippocampus and anterior thalamic nuclei form functional components of the same spatial memory system. Unilateral excitotoxic lesions were placed in the anterior thalamic (AT) nuclei and hippocampus (HPC) in either the same (AT-HPC Ipsi group) or contralateral (AT-HPC Contra group) hemispheres of rats. The behavioral effects of these combined lesions were compared in several spatial memory tasks sensitive to bilateral hippocampal lesions. In all of the tasks tested, T-maze alternation, radial arm maze, and Morris water maze, those animals with lesions placed in the contralateral hemispheres were more impaired than those animals with lesions in the same hemisphere. These results provide direct support for the notion that the performance of tasks that require spatial memory rely on the operation of the anterior thalamus and hippocampus within an integrated neural network.

Key words: hippocampus; spatial memory; anterior thalamus; amnesia; neural networks; rat

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Copyright © 2001 Society for Neuroscience  0270-6474/01/21187323-08$05.00/0

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