QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (50) Citing Articles via Google Scholar Google Scholar Articles by Ramírez-Amaya, V. Articles by Bermúdez-Rattoni, F. Search for Related Content PubMed PubMed Citation Articles by Ramírez-Amaya, V. Articles by Bermúdez-Rattoni, F. Pubmed/NCBI databases Medline Plus Health Information Memory

 Previous Article  |  Next Article 

The Journal of Neuroscience, September 15, 2001, 21(18):7340-7348

Spatial Long-Term Memory Is Related to Mossy Fiber Synaptogenesis

Victor Ramírez-Amaya, Israela Balderas, Jimena Sandoval, Martha L. Escobar, and Federico Bermúdez-Rattoni

Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México

Structural synaptic changes have been suggested to underlie long-term memory formation. In this work, we investigate if hippocampal mossy fiber synaptogenesis induced by water maze overtraining can be related with long-term spatial memory performance. Rats were trained in a Morris water maze for one to five identical daily sessions and tested for memory retrieval 1 week and 1 month after training. After the last test session, the rat brains were obtained and processed for Timm's staining to analyze mossy fiber projection. The behavioral results showed that with more training, animals showed a better performance in the memory tests, and this performance positively correlates with Timm's staining in the stratum oriens. Furthermore, with the use of the NMDA antagonist MK801 before, but not after acquisition, water maze spatial memory was impaired. Increased Timm's staining in the stratum oriens was observed in the animals treated with MK801 after acquisition but not in those treated before. Finally, we observed that mossy fiber synaptogenesis occurs mainly in the septal region of the dorsal hippocampus, supporting the idea that this anterior region is important for spatial memory. Altogether, these results suggest that mossy fiber synaptogenesis can be related with spatial long-term memory formation.

Key words: mossy fiber sprouting; structural changes; hippocampus; long-term memory; dizocilpine; synaptogenesis; CA3; spatial learning

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/21187340-09$05.00/0

This article has been cited by other articles:

				Y. Ding, A. Qiao, Z. Wang, J. S. Goodwin, E.-S. Lee, M. L. Block, M. Allsbrook, M. P. McDonald, and G.-H. Fan Retinoic Acid Attenuates {beta}-Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model J. Neurosci., November 5, 2008; 28(45): 11622 - 11634. [Abstract] [Full Text] [PDF]

				F. Niyuhire, S. A. Varvel, B. R. Martin, and A. H. Lichtman Exposure to Marijuana Smoke Impairs Memory Retrieval in Mice J. Pharmacol. Exp. Ther., September 1, 2007; 322(3): 1067 - 1075. [Abstract] [Full Text] [PDF]

				J. L. Rekart, C. J. Sandoval, F. Bermudez-Rattoni, and A. Routtenberg Remodeling of hippocampal mossy fibers is selectively induced seven days after the acquisition of a spatial but not a cued reference memory task Learn. Mem., June 6, 2007; 14(6): 416 - 421. [Abstract] [Full Text] [PDF]

				W. I. Colon-Cesario, M. M. Martinez-Montemayor, S. Morales, J. Felix, J. Cruz, M. Adorno, L. Pereira, N. Colon, C. S. Maldonado-Vlaar, and S. Pena de Ortiz Knockdown of Nurr1 in the rat hippocampus: Implications to spatial discrimination learning and memory Learn. Mem., November 1, 2006; 13(6): 734 - 744. [Abstract] [Full Text] [PDF]

				P. A. Gusev, C. Cui, D. L. Alkon, and A. N. Gubin Topography of Arc/Arg3.1 mRNA Expression in the Dorsal and Ventral Hippocampus Induced by Recent and Remote Spatial Memory Recall: Dissociation of CA3 and CA1 Activation J. Neurosci., October 12, 2005; 25(41): 9384 - 9397. [Abstract] [Full Text] [PDF]

				E. K. Hebda-Bauer, S. J. Watson, and H. Akil Cognitive performance is highly sensitive to prior experience in mice with a learning and memory deficit: Failure leads to more failure Learn. Mem., September 1, 2005; 12(5): 461 - 471. [Abstract] [Full Text] [PDF]

				D. N. Abrous, M. Koehl, and M. Le Moal Adult Neurogenesis: From Precursors to Network and Physiology Physiol Rev, April 1, 2005; 85(2): 523 - 569. [Abstract] [Full Text] [PDF]

				M. I. Fonseca, J. Zhou, M. Botto, and A. J. Tenner Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease J. Neurosci., July 21, 2004; 24(29): 6457 - 6465. [Abstract] [Full Text] [PDF]

				X.-X. Yan, T. Li, C. M. Rominger, S. R. Prakash, P. C. Wong, R. E. Olson, R. Zaczek, and Y.-W. Li Binding Sites of {gamma}-Secretase Inhibitors in Rodent Brain: Distribution, Postnatal Development, and Effect of Deafferentation J. Neurosci., March 24, 2004; 24(12): 2942 - 2952. [Abstract] [Full Text] [PDF]

				M. Mizuno, K. Yamada, J. He, A. Nakajima, and T. Nabeshima Involvement of BDNF Receptor TrkB in Spatial Memory Formation Learn. Mem., March 1, 2003; 10(2): 108 - 115. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help