 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, October 1, 2001, 21(19):7439-7446
Differential Expression of Apoptotic Protease-Activating Factor-1 and Caspase-3 Genes and Susceptibility to Apoptosis during Brain Development and after Traumatic Brain Injury
Alexander G. Yakovlev1, Katsuya Ota2, Geping Wang1, Vilen Movsesyan1, Wei-Li Bao1, Koichiro Yoshihara2, and Alan I. Faden1 1 Department of Neuroscience, Georgetown University, Washington, DC 20007, and 2 Department of Biochemistry, Nara Medical University, Kashihara, Nara 634-8521, Japan
Neuronal apoptosis plays an essential role in early brain development and contributes to secondary neuronal loss after acute brain injury. Recent studies have provided evidence that neuronal susceptibility to apoptosis induced by traumatic or ischemic injury decreases during brain development. However, the molecular mechanisms responsible for this age-dependent phenomenon remain unclear. Here we demonstrate that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression. A similar decline in apoptotic susceptibility associated with downregulation of Apaf-1 expression as a function of developmental age was also found in cultured primary rat cortical neurons. Injury-induced cytochrome c-specific cleavage of caspase-9 followed by activation of caspase-3 in mature brain correlated with marked increases in Apaf-1 and caspase-3 mRNA and protein expression. These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation.
Key words: brain; development; injury; apoptosis; caspase; gene expression; Apaf-1
Copyright © 2001 Society for Neuroscience 0270-6474/01/21197439-08$05.00/0
This article has been cited by other articles:
S. Villapol, P. Bonnin, S. Fau, O. Baud, S. Renolleau, and C. Charriaut-Marlangue
Unilateral Blood Flow Decrease Induces Bilateral and Symmetric Responses in the Immature Brain
Am. J. Pathol., November 1, 2009; 175(5): 2111 - 2120.
[Abstract] [Full Text] [PDF]
A. Koto, E. Kuranaga, and M. Miura
Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development
J. Cell Biol., October 19, 2009; 187(2): 219 - 231.
[Abstract] [Full Text] [PDF]
Y. Murakami, Y. Ikeda, Y. Yonemitsu, M. Onimaru, K. Nakagawa, R.-i. Kohno, M. Miyazaki, T. Hisatomi, M. Nakamura, T. Yabe, et al.
Inhibition of Nuclear Translocation of Apoptosis-Inducing Factor Is an Essential Mechanism of the Neuroprotective Activity of Pigment Epithelium-Derived Factor in a Rat Model of Retinal Degeneration
Am. J. Pathol., November 1, 2008; 173(5): 1326 - 1338.
[Abstract] [Full Text] [PDF]
Z. Islam, C. C. Hegg, H. K. Bae, and J. J. Pestka
Satratoxin G-Induced Apoptosis in PC-12 Neuronal Cells is Mediated by PKR and Caspase Independent
Toxicol. Sci., September 1, 2008; 105(1): 142 - 152.
[Abstract] [Full Text] [PDF]
C. E. Johnson, Y. Y. Huang, A. B. Parrish, M. I. Smith, A. E. Vaughn, Q. Zhang, K. M. Wright, T. Van Dyke, R. J. Wechsler-Reya, S. Kornbluth, et al.
Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues
PNAS, December 26, 2007; 104(52): 20820 - 20825.
[Abstract] [Full Text] [PDF]
K. M. Wright, M. I. Smith, L. Farrag, and M. Deshmukh
Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons
J. Cell Biol., December 3, 2007; 179(5): 825 - 832.
[Abstract] [Full Text] [PDF]
G. Cao, J. Xing, X. Xiao, A. K. F. Liou, Y. Gao, X.-M. Yin, R. S. B. Clark, S. H. Graham, and J. Chen
Critical Role of Calpain I in Mitochondrial Release of Apoptosis-Inducing Factor in Ischemic Neuronal Injury
J. Neurosci., August 29, 2007; 27(35): 9278 - 9293.
[Abstract] [Full Text] [PDF]
J. W. Kuluz, R. Prado, D. He, W. Zhao, W. D. Dietrich, and B. Watson
New Pediatric Model of Ischemic Stroke in Infant Piglets by Photothrombosis: Acute Changes in Cerebral Blood Flow, Microvasculature, and Early Histopathology
Stroke, June 1, 2007; 38(6): 1932 - 1937.
[Abstract] [Full Text] [PDF]
N. Bahi, J. Zhang, M. Llovera, M. Ballester, J. X. Comella, and D. Sanchis
Switch from Caspase-dependent to Caspase-independent Death during Heart Development: ESSENTIAL ROLE OF ENDONUCLEASE G IN ISCHEMIA-INDUCED DNA PROCESSING OF DIFFERENTIATED CARDIOMYOCYTES
J. Biol. Chem., August 11, 2006; 281(32): 22943 - 22952.
[Abstract] [Full Text] [PDF]
Q. Sang, M. H. Kim, S. Kumar, N. Bye, M. C. Morganti-Kossman, J. Gunnersen, S. Fuller, J. Howitt, L. Hyde, T. Beissbarth, et al.
Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury.
J. Neurosci., July 5, 2006; 26(27): 7234 - 7244.
[Abstract] [Full Text] [PDF]
D. M. Wallace, M. Donovan, and T. G. Cotter
Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina.
Invest. Ophthalmol. Vis. Sci., July 1, 2006; 47(7): 2765 - 2772.
[Abstract] [Full Text] [PDF]
D. P. McKernan, C. Caplis, M. Donovan, C. J. O'Brien, and T. G. Cotter
Age-dependent susceptibility of the retinal ganglion cell layer to cell death.
Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 807 - 814.
[Abstract] [Full Text] [PDF]
M. B. Potts, A. E. Vaughn, H. McDonough, C. Patterson, and M. Deshmukh
Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP
J. Cell Biol., December 19, 2005; 171(6): 925 - 930.
[Abstract] [Full Text] [PDF]
D. Bredesen
Apoptosis versus alternative cell death programs
AACR Meeting Abstracts, April 1, 2005; 2005(1): 1470 - 1471.
[Abstract]
K. M. Wright, M. W. Linhoff, P. R. Potts, and M. Deshmukh
Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis
J. Cell Biol., October 25, 2004; 167(2): 303 - 313.
[Abstract] [Full Text] [PDF]
G. Cao, M. Xiao, F. Sun, X. Xiao, W. Pei, J. Li, S. H. Graham, R. P. Simon, and J. Chen
Cloning of a Novel Apaf-1-Interacting Protein: A Potent Suppressor of Apoptosis and Ischemic Neuronal Cell Death
J. Neurosci., July 7, 2004; 24(27): 6189 - 6201.
[Abstract] [Full Text] [PDF]
R. Li, L. Yang, K. Lindholm, Y. Konishi, X. Yue, H. Hampel, D. Zhang, and Y. Shen
Tumor Necrosis Factor Death Receptor Signaling Cascade Is Required for Amyloid-{beta} Protein-Induced Neuron Death
J. Neurosci., February 18, 2004; 24(7): 1760 - 1771.
[Abstract] [Full Text] [PDF]
S. JAYANTHI, X. DENG, P.-A. H. NOAILLES, B. LADENHEIM, and J. L. CADET
Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascades
FASEB J, February 1, 2004; 18(2): 238 - 251.
[Abstract] [Full Text] [PDF]
F. Doonan, M. Donovan, and T. G. Cotter
Caspase-Independent Photoreceptor Apoptosis in Mouse Models of Retinal Degeneration
J. Neurosci., July 2, 2003; 23(13): 5723 - 5731.
[Abstract] [Full Text] [PDF]
D. Garcia-Domingo, D. Ramirez, G. Gonzalez de Buitrago, and C. Martinez-A
Death Inducer-Obliterator 1 Triggers Apoptosis after Nuclear Translocation and Caspase Upregulation
Mol. Cell. Biol., May 1, 2003; 23(9): 3216 - 3225.
[Abstract] [Full Text] [PDF]
L. Labrada, X. H. Liang, W. Zheng, C. Johnston, and B. Levine
Age-Dependent Resistance to Lethal Alphavirus Encephalitis in Mice: Analysis of Gene Expression in the Central Nervous System and Identification of a Novel Interferon-Inducible Protective Gene, Mouse ISG12
J. Virol., November 15, 2002; 76(22): 11688 - 11703.
[Abstract] [Full Text] [PDF]
W. Liu, G. Wang, and A. G. Yakovlev
Identification and Functional Analysis of the Rat Caspase-3 Gene Promoter
J. Biol. Chem., March 1, 2002; 277(10): 8273 - 8278.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|