 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, October 1, 2001, 21(19):7733-7741
Wisconsin Card Sorting Revisited: Distinct Neural Circuits Participating in Different Stages of the Task Identified by Event-Related Functional Magnetic Resonance Imaging
Oury Monchi1, 2, Michael Petrides2, Valentina Petre1, Keith Worsley1, 3, and Alain Dagher1 1 McConnell Brain Imaging Centre and 2 Cognitive Neuroscience Unit, Montreal Neurological Institute, and 3 Department of Mathematics and Statistics, McGill University, Montréal, Québec, H3A 2B4 Canada
The Wisconsin Card Sorting Task (WCST) has been used to assess dysfunction of the prefrontal cortex and basal ganglia. Previous brain imaging studies have focused on identifying activity related to the set-shifting requirement of the WCST. The present study used event-related functional magnetic resonance imaging (fMRI) to study the pattern of activation during four distinct stages in the performance of this task. Eleven subjects were scanned while performing the WCST and a control task involving matching two identical cards. The results demonstrated specific involvement of different prefrontal areas during different stages of task performance. The mid-dorsolateral prefrontal cortex (area 9/46) increased activity while subjects received either positive or negative feedback, that is at the point when the current information must be related to earlier events stored in working memory. This is consistent with the proposed role of the mid-dorsolateral prefrontal cortex in the monitoring of events in working memory. By contrast, a cortical basal ganglia loop involving the mid-ventrolateral prefrontal cortex (area 47/12), caudate nucleus, and mediodorsal thalamus increased activity specifically during the reception of negative feedback, which signals the need for a mental shift to a new response set. The posterior prefrontal cortex response was less specific; increases in activity occurred during both the reception of feedback and the response period, indicating a role in the association of specific actions to stimuli. The putamen exhibited increased activity while matching after negative feedback but not while matching after positive feedback, implying greater involvement during novel than routine actions.
Key words: basal ganglia; caudate nucleus; fMRI; prefrontal cortex; set-shifting; Wisconsin card sorting
Copyright © 2001 Society for Neuroscience 0270-6474/01/21197733-09$05.00/0
This article has been cited by other articles:
E. M. Syngelaki, S. C. Moore, J. C. Savage, G. Fairchild, and S. H.M. Van Goozen
Executive Functioning and Risky Decision Making in Young Male Offenders
Criminal Justice and Behavior, November 1, 2009; 36(11): 1213 - 1227.
[Abstract] [PDF]
K. Tachibana, K. Suzuki, E. Mori, N. Miura, R. Kawashima, K. Horie, S. Sato, J. Tanji, and H. Mushiake
Neural Activity in the Human Brain Signals Logical Rule Identification
J Neurophysiol, September 1, 2009; 102(3): 1526 - 1537.
[Abstract] [Full Text] [PDF]
A. Simmons, I. A. Strigo, S. C. Matthews, M. P. Paulus, and M. B. Stein
Initial Evidence of a Failure to Activate Right Anterior Insula During Affective Set Shifting in Posttraumatic Stress Disorder
Psychosom Med, May 1, 2009; 71(4): 373 - 377.
[Abstract] [Full Text] [PDF]
G. L. Shulman, S. V. Astafiev, D. Franke, D. L. W. Pope, A. Z. Snyder, M. P. McAvoy, and M. Corbetta
Interaction of Stimulus-Driven Reorienting and Expectation in Ventral and Dorsal Frontoparietal and Basal Ganglia-Cortical Networks
J. Neurosci., April 8, 2009; 29(14): 4392 - 4407.
[Abstract] [Full Text] [PDF]
Y. Moriguchi and K. Hiraki
Neural origin of cognitive shifting in young children
PNAS, April 7, 2009; 106(14): 6017 - 6021.
[Abstract] [Full Text] [PDF]
S. L. Bengtsson, H. C. Lau, and R. E. Passingham
Motivation to do Well Enhances Responses to Errors and Self-Monitoring
Cereb Cortex, April 1, 2009; 19(4): 797 - 804.
[Abstract] [Full Text] [PDF]
J. Chikazoe, K. Jimura, T. Asari, K.-i. Yamashita, H. Morimoto, S. Hirose, Y. Miyashita, and S. Konishi
Functional Dissociation in Right Inferior Frontal Cortex during Performance of Go/No-Go Task
Cereb Cortex, January 1, 2009; 19(1): 146 - 152.
[Abstract] [Full Text] [PDF]
E. A. CRONE, K. ZANOLIE, L. VAN LEIJENHORST, M. P. WESTENBERG, and S. A. R. B. ROMBOUTS
Neural mechanisms supporting flexible performance adjustment during development
Cogn Affect Behav Neurosci, June 1, 2008; 8(2): 165 - 177.
[Abstract] [PDF]
A. Nagano-Saito, M. Leyton, O. Monchi, Y. K. Goldberg, Y. He, and A. Dagher
Dopamine Depletion Impairs Frontostriatal Functional Connectivity during a Set-Shifting Task
J. Neurosci., April 2, 2008; 28(14): 3697 - 3706.
[Abstract] [Full Text] [PDF]
M. G. Baxter, P. G.F. Browning, and A. S. Mitchell
Perseverative interference with object-in-place scene learning in rhesus monkeys with bilateral ablation of ventrolateral prefrontal cortex
Learn. Mem., March 1, 2008; 15(3): 126 - 132.
[Abstract] [Full Text] [PDF]
A. F. Rossi, N. P. Bichot, R. Desimone, and L. G. Ungerleider
Top Down Attentional Deficits in Macaques with Lesions of Lateral Prefrontal Cortex
J. Neurosci., October 17, 2007; 27(42): 11306 - 11314.
[Abstract] [Full Text] [PDF]
J. Lepsien and A. C. Nobre
Attentional Modulation of Object Representations in Working Memory
Cereb Cortex, September 1, 2007; 17(9): 2072 - 2083.
[Abstract] [Full Text] [PDF]
M. Brass and P. Haggard
To Do or Not to Do: The Neural Signature of Self-Control
J. Neurosci., August 22, 2007; 27(34): 9141 - 9145.
[Abstract] [Full Text] [PDF]
M. L. Phillips and E. Vieta
Identifying Functional Neuroimaging Biomarkers of Bipolar Disorder: Toward DSM-V
Schizophr Bull, July 1, 2007; 33(4): 893 - 904.
[Abstract] [Full Text] [PDF]
A. E. Block, H. Dhanji, S. F. Thompson-Tardif, and S. B. Floresco
Thalamic-Prefrontal Cortical-Ventral Striatal Circuitry Mediates Dissociable Components of Strategy Set Shifting
Cereb Cortex, July 1, 2007; 17(7): 1625 - 1636.
[Abstract] [Full Text] [PDF]
S. Kuboshima-Amemori and T. Sawaguchi
Plasticity of the Primate Prefrontal Cortex
Neuroscientist, June 1, 2007; 13(3): 229 - 240.
[Abstract] [PDF]
D. Papo, A. Douiri, F. Bouchet, J.-C. Bourzeix, J.-P. Caverni, and P.-M. Baudonniere
Time-Frequency Intracranial Source Localization of Feedback-Related EEG Activity in Hypothesis Testing
Cereb Cortex, June 1, 2007; 17(6): 1314 - 1322.
[Abstract] [Full Text] [PDF]
T.W Robbins
Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications
Phil Trans R Soc B, May 29, 2007; 362(1481): 917 - 932.
[Abstract] [Full Text] [PDF]
O. Monchi, M. Petrides, B. Mejia-Constain, and A. P. Strafella
Cortical activity in Parkinson's disease during executive processing depends on striatal involvement
Brain, January 1, 2007; 130(1): 233 - 244.
[Abstract] [Full Text] [PDF]
C. A. Seger and C. M. Cincotta
Dynamics of Frontal, Striatal, and Hippocampal Systems during Rule Learning
Cereb Cortex, November 1, 2006; 16(11): 1546 - 1555.
[Abstract] [Full Text] [PDF]
M. H. S. Rolfe, M. Hausmann, and K. E. Waldie
Hemispheric functioning in children with subtypes of attention-deficit/hyperactivity disorder.
J Atten Disord, August 1, 2006; 10(1): 20 - 27.
[Abstract] [PDF]
F. A. Mansouri, K. Matsumoto, and K. Tanaka
Prefrontal cell activities related to monkeys' success and failure in adapting to rule changes in a Wisconsin Card Sorting Test analog.
J. Neurosci., March 8, 2006; 26(10): 2745 - 2756.
[Abstract] [Full Text] [PDF]
S. B. Floresco, S. Ghods-Sharifi, C. Vexelman, and O. Magyar
Dissociable Roles for the Nucleus Accumbens Core and Shell in Regulating Set Shifting
J. Neurosci., March 1, 2006; 26(9): 2449 - 2457.
[Abstract] [Full Text] [PDF]
J. Jonides and D. E. Nee
Assessing Dysfunction Using Refined Cognitive Methods
Schizophr Bull, October 1, 2005; 31(4): 823 - 829.
[Abstract] [Full Text] [PDF]
S. Konishi, J. Chikazoe, K. Jimura, T. Asari, and Y. Miyashita
Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference
PNAS, August 30, 2005; 102(35): 12584 - 12588.
[Abstract] [Full Text] [PDF]
S. Tsujimoto and T. Sawaguchi
Context-dependent Representation of Response-outcome in Monkey Prefrontal Neurons
Cereb Cortex, July 1, 2005; 15(7): 888 - 898.
[Abstract] [Full Text] [PDF]
N. Yeung, C. B. Holroyd, and J. D. Cohen
ERP Correlates of Feedback and Reward Processing in the Presence and Absence of Response Choice
Cereb Cortex, May 1, 2005; 15(5): 535 - 544.
[Abstract] [Full Text] [PDF]
C. A. Seger and C. M. Cincotta
The Roles of the Caudate Nucleus in Human Classification Learning
J. Neurosci., March 16, 2005; 25(11): 2941 - 2951.
[Abstract] [Full Text] [PDF]
Y Nagahama, T Okina, N Suzuki, H Nabatame, and M Matsuda
The cerebral correlates of different types of perseveration in the Wisconsin Card Sorting Test
J. Neurol. Neurosurg. Psychiatry, February 1, 2005; 76(2): 169 - 175.
[Abstract] [Full Text] [PDF]
H. Johansen-Berg, T. E.J. Behrens, E. Sillery, O. Ciccarelli, A. J. Thompson, S. M. Smith, and P. M. Matthews
Functional-Anatomical Validation and Individual Variation of Diffusion Tractography-based Segmentation of the Human Thalamus
Cereb Cortex, January 1, 2005; 15(1): 31 - 39.
[Abstract] [Full Text] [PDF]
M. Brass and D. Y. von Cramon
Selection for Cognitive Control: A Functional Magnetic Resonance Imaging Study on the Selection of Task-Relevant Information
J. Neurosci., October 6, 2004; 24(40): 8847 - 8852.
[Abstract] [Full Text] [PDF]
Y. Watanabe and S. Funahashi
Neuronal Activity Throughout the Primate Mediodorsal Nucleus of the Thalamus During Oculomotor Delayed-Responses. I. Cue-, Delay-, and Response-Period Activity
J Neurophysiol, September 1, 2004; 92(3): 1738 - 1755.
[Abstract] [Full Text] [PDF]
A. R. Aron, S. Monsell, B. J. Sahakian, and T. W. Robbins
A componential analysis of task-switching deficits associated with lesions of left and right frontal cortex
Brain, July 1, 2004; 127(7): 1561 - 1573.
[Abstract] [Full Text] [PDF]
R. Cools, L. Clark, and T. W. Robbins
Differential Responses in Human Striatum and Prefrontal Cortex to Changes in Object and Rule Relevance
J. Neurosci., February 4, 2004; 24(5): 1129 - 1135.
[Abstract] [Full Text] [PDF]
O. Monchi, M. Petrides, J. Doyon, R. B. Postuma, K. Worsley, and A. Dagher
Neural Bases of Set-Shifting Deficits in Parkinson's Disease
J. Neurosci., January 21, 2004; 24(3): 702 - 710.
[Abstract] [Full Text] [PDF]
A. Diamond, L. Briand, J. Fossella, and L. Gehlbach
Genetic and Neurochemical Modulation of Prefrontal Cognitive Functions in Children
Am J Psychiatry, January 1, 2004; 161(1): 125 - 132.
[Abstract] [Full Text] [PDF]
J. C. Eliassen, T. Souza, and J. N. Sanes
Experience-Dependent Activation Patterns in Human Brain during Visual-Motor Associative Learning
J. Neurosci., November 19, 2003; 23(33): 10540 - 10547.
[Abstract] [Full Text] [PDF]
J. D. Wallis and E. K. Miller
From Rule to Response: Neuronal Processes in the Premotor and Prefrontal Cortex
J Neurophysiol, September 1, 2003; 90(3): 1790 - 1806.
[Abstract] [Full Text] [PDF]
S. Konishi, K. Jimura, T. Asari, and Y. Miyashita
Transient Activation of Superior Prefrontal Cortex during Inhibition of Cognitive Set
J. Neurosci., August 27, 2003; 23(21): 7776 - 7782.
[Abstract] [Full Text] [PDF]
R. Cools, L. Clark, A. M. Owen, and T. W. Robbins
Defining the Neural Mechanisms of Probabilistic Reversal Learning Using Event-Related Functional Magnetic Resonance Imaging
J. Neurosci., June 1, 2002; 22(11): 4563 - 4567.
[Abstract] [Full Text] [PDF]
S. Konishi, T. Hayashi, I. Uchida, H. Kikyo, E. Takahashi, and Y. Miyashita
Hemispheric asymmetry in human lateral prefrontal cortex during cognitive set shifting
PNAS, May 28, 2002; 99(11): 7803 - 7808.
[Abstract] [Full Text] [PDF]
K. Nakahara, T. Hayashi, S. Konishi, and Y. Miyashita
Functional MRI of Macaque Monkeys Performing a Cognitive Set-Shifting Task
Science, February 22, 2002; 295(5559): 1532 - 1536.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|