 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, January 15, 2001, 21(2):676-681
Amygdala Regulation of Nucleus Accumbens Dopamine Output is Governed by the Prefrontal Cortex
Mark E. Jackson and Bita Moghaddam Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut 06516
A dynamic interaction between the prefrontal cortex (PFC), amygdala, and nucleus accumbens (NAc) may be fundamental to regulation of goal-directed behavior by affective and cognitive processes. This study demonstrates that a mechanism for this triadic relationship is an inhibitory control by prefrontal cortex on accumbal dopamine release during amygdala activation. In freely moving rats, microstimulation of basolateral amygdala at intensities that produced mild behavioral activation produced an expected rapid increase in glutamate efflux in the prefrontal cortex and the nucleus accumbens shell region of the ventral striatum. However, during the stimulation, dopamine release increased only in the prefrontal cortex, not in the nucleus accumbens. An increase in accumbal dopamine release was observed during the stimulation if glutamate activation in the prefrontal cortex was inhibited at either presynaptic or postsynaptic levels. Some behaviors expressed during the stimulation were intensified in animals in which prefrontal cortex glutamate activation was blocked. In addition, these animals continued to express stimulus-induced behaviors after the termination of stimulation, whereas normal poststimulus behaviors such as ambulation and grooming were not displayed as frequently. Considering that dopamine neurotransmission in the nucleus accumbens is thought to play an integral role in goal-directed motor behavior, these findings suggest that the prefrontal cortex influences the behavioral impact of amygdala activation via a concomitant active suppression of accumbal dopamine release. Absence of this cortical influence appears to result in an aberrant pattern of behavioral expression in response to amygdala activation, including behavioral perseveration after stimulus termination.
Key words: AMPA; striatum; ventral tegmental area; metabotropic glutamate receptors; schizophrenia; motivation
Copyright © 2001 Society for Neuroscience 0270-6474/01/212676-06$05.00/0
This article has been cited by other articles:
C. O. Tan and D. Bullock
A Dopamine-Acetylcholine Cascade: Simulating Learned and Lesion-Induced Behavior of Striatal Cholinergic Interneurons
J Neurophysiol, October 1, 2008; 100(4): 2409 - 2421.
[Abstract] [Full Text] [PDF]
B. S. Peterson, H. A. Choi, X. Hao, J. A. Amat, H. Zhu, R. Whiteman, J. Liu, D. Xu, and R. Bansal
Morphologic Features of the Amygdala and Hippocampus in Children and Adults With Tourette Syndrome
Arch Gen Psychiatry, November 1, 2007; 64(11): 1281 - 1291.
[Abstract] [Full Text] [PDF]
S. B. Floresco and M. T. Tse
Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala-Prefrontal Cortical Pathway
J. Neurosci., February 21, 2007; 27(8): 2045 - 2057.
[Abstract] [Full Text] [PDF]
S. Tsujimoto and T. Sawaguchi
Context-dependent Representation of Response-outcome in Monkey Prefrontal Neurons
Cereb Cortex, July 1, 2005; 15(7): 888 - 898.
[Abstract] [Full Text] [PDF]
B. Roozendaal, J. R. McReynolds, and J. L. McGaugh
The Basolateral Amygdala Interacts with the Medial Prefrontal Cortex in Regulating Glucocorticoid Effects on Working Memory Impairment
J. Neurosci., February 11, 2004; 24(6): 1385 - 1392.
[Abstract] [Full Text] [PDF]
A. Christakou, T. W. Robbins, and B. J. Everitt
Prefrontal Cortical-Ventral Striatal Interactions Involved in Affective Modulation of Attentional Performance: Implications for Corticostriatal Circuit Function
J. Neurosci., January 28, 2004; 24(4): 773 - 780.
[Abstract] [Full Text] [PDF]
M. A. Pezze, T. Bast, and J. Feldon
Significance of Dopamine Transmission in the Rat Medial Prefrontal Cortex for Conditioned Fear
Cereb Cortex, April 1, 2003; 13(4): 371 - 380.
[Abstract] [Full Text] [PDF]
S. Ahn and A. G. Phillips
Modulation by Central and Basolateral Amygdalar Nuclei of Dopaminergic Correlates of Feeding to Satiety in the Rat Nucleus Accumbens and Medial Prefrontal Cortex
J. Neurosci., December 15, 2002; 22(24): 10958 - 10965.
[Abstract] [Full Text] [PDF]
M. E. Walton, D. M. Bannerman, and M. F. S. Rushworth
The Role of Rat Medial Frontal Cortex in Effort-Based Decision Making
J. Neurosci., December 15, 2002; 22(24): 10996 - 11003.
[Abstract] [Full Text] [PDF]
A. E. Kelley and K. C. Berridge
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
J. Neurosci., May 1, 2002; 22(9): 3306 - 3311.
[Full Text] [PDF]
R. Adolphs
Recognizing emotion from facial expressions: psychological and neurological mechanisms.
Behav Cogn Neurosci Rev, March 1, 2002; 1(1): 21 - 62.
[Abstract] [PDF]
J. G. Howland, P. Taepavarapruk, and A. G. Phillips
Glutamate Receptor-Dependent Modulation of Dopamine Efflux in the Nucleus Accumbens by Basolateral, But Not Central, Nucleus of the Amygdala in Rats
J. Neurosci., February 1, 2002; 22(3): 1137 - 1145.
[Abstract] [Full Text] [PDF]
C. L. Wyvell and K. C. Berridge
Incentive Sensitization by Previous Amphetamine Exposure: Increased Cue-Triggered "Wanting" for Sucrose Reward
J. Neurosci., October 1, 2001; 21(19): 7831 - 7840.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|