QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (37) Citing Articles via Google Scholar Google Scholar Articles by Ohyama, T. Articles by Mauk, M. D. Search for Related Content PubMed PubMed Citation Articles by Ohyama, T. Articles by Mauk, M. D.

 Previous Article  |  Next Article 

The Journal of Neuroscience, January 15, 2001, 21(2):682-690

Latent Acquisition of Timed Responses in Cerebellar Cortex

Tatsuya Ohyama and Michael D. Mauk

Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225

Evidence indicates that rabbit eyelid conditioning is mediated by plasticity in the interpositus cerebellar nucleus and in cerebellar cortex. Although the relative contributions of these sites are not fully characterized, evidence suggests that plasticity in the cerebellar cortex influences conditioned response amplitude and timing, whereas plasticity in the interpositus nucleus is necessary or permissive for conditioned response expression. Recent empirical and computational analyses suggest that, during training, plasticity is initially established in the cerebellar cortex, whereas conditioned response expression begins later as plasticity is induced in the interpositus nucleus. We used the dependence of response timing on the interstimulus interval (ISI) to test this latent learning hypothesis. Rabbits were initially trained using a tone conditioned stimulus (CS) with a relatively long ISI to a low-criterion threshold. The relative absence of plasticity in the interpositus nucleus was then examined via reversible disconnection of the cerebellar cortex. Later, to induce plasticity in the interpositus nucleus, subjects were trained to robust levels of conditioned response expression using a shorter ISI. Reversible disconnection of the cerebellar cortex at this time confirmed the presence of robust interpositus nucleus plasticity after the second phase. Subsequent probe trials with the long CS alone then revealed double-peaked responses whose peaks were appropriately timed to the two ISIs. The results are consistent with the hypothesis that temporally specific learning occurs first in the cerebellar cortex before the appearance of conditioned responses. This latent learning is expressed only after plasticity is induced in the interpositus nucleus.

Key words: cerebellar cortex; eyelid conditioning; interpositus nucleus; latent learning; learning; plasticity; response timing

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/212682-09$05.00/0

This article has been cited by other articles:

				M. Ohki, H. Kitazawa, T. Hiramatsu, K. Kaga, T. Kitamura, J. Yamada, and S. Nagao Role of Primate Cerebellar Hemisphere in Voluntary Eye Movement Control Revealed by Lesion Effects J Neurophysiol, February 1, 2009; 101(2): 934 - 947. [Abstract] [Full Text] [PDF]

				J. R. Pugh and I. M. Raman Mechanisms of Potentiation of Mossy Fiber EPSCs in the Cerebellar Nuclei by Coincident Synaptic Excitation and Inhibition J. Neurosci., October 15, 2008; 28(42): 10549 - 10560. [Abstract] [Full Text] [PDF]

				D. Z. Wetmore, E. A. Mukamel, and M. J. Schnitzer Lock-and-Key Mechanisms of Cerebellar Memory Recall Based on Rebound Currents J Neurophysiol, October 1, 2008; 100(4): 2328 - 2347. [Abstract] [Full Text] [PDF]

				D.-A. Jirenhed, F. Bengtsson, and G. Hesslow Acquisition, Extinction, and Reacquisition of a Cerebellar Cortical Memory Trace J. Neurosci., March 7, 2007; 27(10): 2493 - 2502. [Abstract] [Full Text] [PDF]

				T. Ohyama, W. L. Nores, J. F. Medina, F. A. Riusech, and M. D. Mauk Learning-Induced Plasticity in Deep Cerebellar Nucleus J. Neurosci., December 6, 2006; 26(49): 12656 - 12663. [Abstract] [Full Text] [PDF]

				B. C. Nolan and J. H. Freeman Purkinje cell loss by OX7-saporin impairs acquisition and extinction of eyeblink conditioning. Learn. Mem., May 1, 2006; 13(3): 359 - 365. [Abstract] [Full Text] [PDF]

				J. T. Green and J. E. Steinmetz Purkinje cell activity in the cerebellar anterior lobe after rabbit eyeblink conditioning Learn. Mem., May 1, 2005; 12(3): 260 - 269. [Abstract] [Full Text] [PDF]

				M. D. Mauk and T. Ohyama Extinction as New Learning Versus Unlearning: Considerations from a Computer Simulation of the Cerebellum Learn. Mem., September 1, 2004; 11(5): 566 - 571. [Abstract] [Full Text] [PDF]

				D. M. Broussard and C. D. Kassardjian Learning in a Simple Motor System Learn. Mem., March 1, 2004; 11(2): 127 - 136. [Abstract] [Full Text] [PDF]

				T. Ohyama, W. L. Nores, and M. D. Mauk Stimulus Generalization of Conditioned Eyelid Responses Produced Without Cerebellar Cortex: Implications for Plasticity in the Cerebellar Nuclei Learn. Mem., September 1, 2003; 10(5): 346 - 354. [Abstract] [Full Text] [PDF]

				S. Bao, L. Chen, J. J. Kim, and R. F. Thompson Cerebellar cortical inhibition and classical eyeblink conditioning PNAS, January 17, 2002; (2002) 32655399. [Abstract] [Full Text] [PDF]

				P. J. E. Attwell, S. Rahman, and C. H. Yeo Acquisition of Eyeblink Conditioning Is Critically Dependent on Normal Function in Cerebellar Cortical Lobule HVI J. Neurosci., August 1, 2001; 21(15): 5715 - 5722. [Abstract] [Full Text] [PDF]

				S. Bao, L. Chen, J. J. Kim, and R. F. Thompson Cerebellar cortical inhibition and classical eyeblink conditioning PNAS, February 5, 2002; 99(3): 1592 - 1597. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help