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The Journal of Neuroscience, October 15, 2001, 21(20):8270-8277
Coincident Spiking Activity Induces Long-Term Changes in
Inhibition of Neocortical Pyramidal Cells
Carl D.
Holmgren and
Yuri
Zilberter
Karolinska Institute, Department of Neuroscience, Division of
Neuroanatomy and Brain Development, S-17177 Stockholm, Sweden
In pyramidal cells, induction of long-term potentiation (LTP) and
long-term depression (LTD) of excitatory synaptic transmission by coincidence of presynaptic and postsynaptic activity is considered relevant to learning processes in vivo. Here we show
that temporally correlated spiking activity of a pyramidal cell and an
inhibiting interneuron may cause LTD or LTP of unitary IPSPs. Polarity
of change in synaptic efficacy depends on timing between
Ca2+ influx induced by a backpropagating train of
action potentials (APs) in pyramidal cell dendrites (10 APs, 50 Hz) and
subsequent activation of inhibitory synapses. LTD of IPSPs was induced
by synaptic activation in the vicinity of the AP train (<300 msec relative to the beginning of the train), whereas LTP of IPSPs was
initiated with more remote synaptic activation (>400 msec relative to
the beginning of the AP train). Solely AP trains induced neither LTP
nor LTD. Both LTP and LTD were prevented by 5 mM BAPTA loaded into pyramidal cells. LTD was prevented by 5 mM
EGTA, whereas EGTA failed to affect LTP. Synaptic plasticity was not
dependent on activation of GABAB receptors. It was also not
affected by the antagonists of vesicular exocytosis, botulinum toxin D,
and GDP- -S.
Key words:
neocortex; interneuron; pyramidal cell; LTP; LTD; coincident detection
Copyright © 2001 Society for Neuroscience 0270-6474/01/21208270-08$05.00/0
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