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The Journal of Neuroscience, November 15, 2001, 21(22):8906-8914

Spontaneous Activity in Developing Ferret Visual Cortex In Vivo

Chiayu Chiu¹ and Michael Weliky²

¹ Interdepartmental Program in Neuroscience and ² Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York 14627

Multi-electrode extracellular recordings in area 17 of awake behaving ferrets were conducted to characterize the pattern of spontaneous activity in the developing visual cortex before eye opening. A linear array of 16 microwire electrodes was used to record extracellular neuronal activity across a 3.2 mm strip of visual cortex between postnatal days 22 and 28. Whereas synchronous bursts of activity were observed at all recording sites, cross-correlation analysis revealed that the timing of spike activity at all electrodes was not precisely correlated. Correlated activity between cortical sites exhibited a patchy organization having long-range components. Long-range correlated activity was observed between cortical patches that were separated by a mean distance of 1 mm. The spatial pattern of correlated activity persisted during transient lateral geniculate nucleus (LGN) activity block, indicating that long-range correlated activity is generated by intrinsic circuits within the cortex, independent of LGN input activity. These results demonstrate an innate patchy organization of correlated spontaneous activity within the cortex during the early development of cortical functional and anatomical organization.

Key words: extracellular recording; area 17; ferret; correlated activity; multi-electrode; visual cortical development

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Copyright © 2001 Society for Neuroscience  0270-6474/01/21228906-09$05.00/0

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