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The Journal of Neuroscience, December 1, 2001, 21(23):9304-9314

Roles of the Telencephalic Cells and their Chondroitin Sulfate Proteoglycans in Delimiting an Anterior Border of the Retinal Pathway

Hiroyuki Ichijo and Izumi Kawabata

Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

The axons of the retinal ganglion cells run on the diencephalotelencephalic boundary on their way to the tectum; however, they do not invade the telencephalon anteriorly. To investigate the mechanisms that prevent the retinal axons from entering the telencephalic territory, the effects of the telencephalic cells were examined on the outgrowth of the retinal axons in vitro; the retinal outgrowth was selectively inhibited by the cellular substrate derived from the telencephalon. The responsible factor for the selective inhibition was, furthermore, found in the telencephalic membranes and the fraction of peripheral membrane molecules from the telencephalon. Because the inhibitory effect was destroyed by chondroitinase ABC but not by heat, this inhibition was attributable to the carbohydrate chains of chondroitin sulfate proteoglycans (CSPGs) adhering to the membranes of the telencephalic cells. To understand the function of the telencephalic CSPGs on the retinal pathfinding in vivo, their carbohydrate chains [chondroitin sulfate glycosaminoglycan (CS-GAG)] were removed from the embryonic brains by intraventricular injection of chondroitinase ABC; the removal of CS-GAG resulted in an anterior enlargement of the optic tract. The results indicate that the telencephalic cells delimit the anterior border of the optic tract with their CSPGs and prevent the retinal axons from aberrantly entering the anterior territory.

Key words: axon guidance; pathfinding; retinotectal projection; optic tract; retinal ganglion cell; chondroitin sulfate proteoglycan; telencephalon

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Copyright © 2001 Society for Neuroscience  0270-6474/01/21239304-11$05.00/0

This article has been cited by other articles:

				H. Wang, Y. Katagiri, T. E. McCann, E. Unsworth, P. Goldsmith, Z.-X. Yu, F. Tan, L. Santiago, E. M. Mills, Y. Wang, et al. Chondroitin-4-sulfation negatively regulates axonal guidance and growth J. Cell Sci., September 15, 2008; 121(18): 3083 - 3091. [Abstract] [Full Text] [PDF]

				N. Maeda, J. He, Y. Yajima, T. Mikami, K. Sugahara, and T. Yabe Heterogeneity of the Chondroitin Sulfate Portion of Phosphacan/6B4 Proteoglycan Regulates Its Binding Affinity for Pleiotrophin/Heparin Binding Growth-associated Molecule J. Biol. Chem., September 12, 2003; 278(37): 35805 - 35811. [Abstract] [Full Text] [PDF]

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