 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, December 15, 2001, 21(24):9598-9607
Roles for Mitochondrial and Reverse Mode Na+/Ca2+ Exchange and the Plasmalemma Ca2+ ATPase in Post-Tetanic Potentiation at Crayfish Neuromuscular Junctions
Ning Zhong, Vahri Beaumont, and Robert S. Zucker Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720-3200
We have explored the processes regulating presynaptic calcium concentration ([Ca2+]i) in the generation of post-tetanic potentiation (PTP) at crayfish neuromuscular junctions, using spectrophotometric dyes to measure changes in [Ca2+]i and [Na+]i and effects of inhibitors of Ca2+-transport processes. The mitochondrial Na+/Ca2+ exchange inhibitor CGP 37157 was without effect, whereas the reverse mode plasmalemmal Na+/Ca2+ exchange inhibitor KB R7943 reduced PTP and Ca2+ accumulation caused by increased [Na+]i. Exchange inhibitory peptide and C28R2 had opposite effects, consistent with their block of the plasma membrane Ca2+ ATPase. All drugs except CGP 37157 reduced Ca2+ accumulation caused by Na+ accumulation, which occurred on block of the Na+/K+ pump, acting in proportion to their effects on plasmalemmal Na+/Ca2+ exchange. We find no role for mitochondrial Na+/Ca2+ exchange in presynaptic Ca2+ regulation. The plasma membrane Na+/Ca2+ exchanger acts in reverse mode to admit Ca2+ into nerve terminals during and for some minutes after tetanic stimulation, while at the same time the plasma membrane Ca2+ ATPase operates as an important Ca2+ removal process. The interplay of these two Ca2+ transport processes with Na+-independent mitochondrial Ca2+ fluxes and the plasmalemma Na+/K+ pump determines the magnitude of tetanic [Ca2+]i accumulation and potentiation of excitatory transmission, and the post-tetanic time courses of decay of elevated [Ca2+]i and PTP.
Key words: post-tetanic potentiation; Na+/Ca2+ exchange; Ca2+ ATPase; mitochondria; transmitter release; crayfish; neuromuscular junction; synaptic transmission
Copyright © 2001 Society for Neuroscience 0270-6474/01/21249598-10$05.00/0
This article has been cited by other articles:
M. K. Klose, G. L. Boulianne, R. M. Robertson, and H. L. Atwood
Role of ATP-Dependent Calcium Regulation in Modulation of Drosophila Synaptic Thermotolerance
J Neurophysiol, August 1, 2009; 102(2): 901 - 913.
[Abstract] [Full Text] [PDF]
R. C. Reyes and V. Parpura
Mitochondria Modulate Ca2+-Dependent Glutamate Release from Rat Cortical Astrocytes
J. Neurosci., September 24, 2008; 28(39): 9682 - 9691.
[Abstract] [Full Text] [PDF]
J. E. Geiger and N. S. Magoski
Ca2+-Induced Ca2+ Release in Aplysia Bag Cell Neurons Requires Interaction Between Mitochondrial and Endoplasmic Reticulum Stores
J Neurophysiol, July 1, 2008; 100(1): 24 - 37.
[Abstract] [Full Text] [PDF]
M. E. Quinlan, C. O. Alberto, and M. Hirasawa
Short-term potentiation of mEPSCs requires N-, P/Q- and L-type Ca2+ channels and mitochondria in the supraoptic nucleus
J. Physiol., July 1, 2008; 586(13): 3147 - 3161.
[Abstract] [Full Text] [PDF]
Y. V. Medvedeva, M.-S. Kim, and Y. M. Usachev
Mechanisms of Prolonged Presynaptic Ca2+ Signaling and Glutamate Release Induced by TRPV1 Activation in Rat Sensory Neurons
J. Neurosci., May 14, 2008; 28(20): 5295 - 5311.
[Abstract] [Full Text] [PDF]
L. B. Silverman-Gavrila and A. J. Smith
Facilitating exchange: activity-dependent regulation of presynaptic Na+/Ca2+ exchange
J. Physiol., April 15, 2008; 586(8): 2039 - 2040.
[Full Text] [PDF]
D. Lee, K.-H. Lee, W.-K. Ho, and S.-H. Lee
Target Cell-Specific Involvement of Presynaptic Mitochondria in Post-Tetanic Potentiation at Hippocampal Mossy Fiber Synapses
J. Neurosci., December 12, 2007; 27(50): 13603 - 13613.
[Abstract] [Full Text] [PDF]
A. Minami, Y.-f. Xia, and R. S. Zucker
Increased Ca2+ influx through Na+/Ca2+ exchanger during long-term facilitation at crayfish neuromuscular junctions
J. Physiol., December 1, 2007; 585(2): 413 - 427.
[Abstract] [Full Text] [PDF]
B. Yang, R. Desai, and L. K. Kaczmarek
Slack and Slick KNa Channels Regulate the Accuracy of Timing of Auditory Neurons
J. Neurosci., March 7, 2007; 27(10): 2617 - 2627.
[Abstract] [Full Text] [PDF]
H. F. Altimimi and P. P. M. Schnetkamp
Na+-dependent Inactivation of the Retinal Cone/Brain Na+/Ca2+-K+ Exchanger NCKX2
J. Biol. Chem., February 9, 2007; 282(6): 3720 - 3729.
[Abstract] [Full Text] [PDF]
F. Felmy and H. von Gersdorff
Late Switch for Post-Tetanic Potentiation: Once Again It's Ca2+. Focus on "An Increase in Calcium Influx Contributes to Post-Tetanic Potentiation at the Rat Calyx of Held Synapse"
J Neurophysiol, December 1, 2006; 96(6): 2840 - 2841.
[Full Text] [PDF]
G. A. Lnenicka, J. Grizzaffi, B. Lee, and N. Rumpal
Ca2+ Dynamics along Identified Synaptic Terminals in Drosophila Larvae.
J. Neurosci., November 22, 2006; 26(47): 12283 - 12293.
[Abstract] [Full Text] [PDF]
B. W. Bernstein, H. Chen, J. A. Boyle, and J. R. Bamburg
Formation of actin-ADF/cofilin rods transiently retards decline of mitochondrial potential and ATP in stressed neurons
Am J Physiol Cell Physiol, November 1, 2006; 291(5): C828 - C839.
[Abstract] [Full Text] [PDF]
L. E. Garcia-Chacon, K. T. Nguyen, G. David, and E. F. Barrett
Extrusion of Ca2+ from mouse motor terminal mitochondria via a Na+-Ca2+ exchanger increases post-tetanic evoked release
J. Physiol., August 1, 2006; 574(3): 663 - 675.
[Abstract] [Full Text] [PDF]
J. L. Duncan, H. Yang, T. Doan, R. S. Silverstein, G. J. Murphy, G. Nune, X. Liu, D. Copenhagen, B. L. Tempel, F. Rieke, et al.
Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion.
J. Neurosci., July 5, 2006; 26(27): 7201 - 7211.
[Abstract] [Full Text] [PDF]
O. Zamir and M. P. Charlton
Cholesterol and synaptic transmitter release at crayfish neuromuscular junctions
J. Physiol., February 15, 2006; 571(1): 83 - 99.
[Abstract] [Full Text] [PDF]
J.-W. Lin, Q. Fu, and T. Allana
Probing the Endogenous Ca2+ Buffers at the Presynaptic Terminals of the Crayfish Neuromuscular Junction
J Neurophysiol, July 1, 2005; 94(1): 377 - 386.
[Abstract] [Full Text] [PDF]
M.-H. Kim, N. Korogod, R. Schneggenburger, W.-K. Ho, and S.-H. Lee
Interplay between Na+/Ca2+ Exchangers and Mitochondria in Ca2+ Clearance at the Calyx of Held
J. Neurosci., June 29, 2005; 25(26): 6057 - 6065.
[Abstract] [Full Text] [PDF]
N. Korogod, X. Lou, and R. Schneggenburger
Presynaptic Ca2+ Requirements and Developmental Regulation of Posttetanic Potentiation at the Calyx of Held
J. Neurosci., May 25, 2005; 25(21): 5127 - 5137.
[Abstract] [Full Text] [PDF]
R. L. P Habets and J. G. G Borst
Post-tetanic potentiation in the rat calyx of Held synapse
J. Physiol., April 1, 2005; 564(1): 173 - 187.
[Abstract] [Full Text] [PDF]
A. G. Millar, R. S. Zucker, G. C. R. Ellis-Davies, M. P. Charlton, and H. L. Atwood
Calcium Sensitivity of Neurotransmitter Release Differs at Phasic and Tonic Synapses
J. Neurosci., March 23, 2005; 25(12): 3113 - 3125.
[Abstract] [Full Text] [PDF]
N. Zhong, V. Beaumont, and R. S. Zucker
Calcium Influx Through HCN Channels Does Not Contribute to cAMP-Enhanced Transmission
J Neurophysiol, July 1, 2004; 92(1): 644 - 647.
[Abstract] [Full Text] [PDF]
N. Zhong and R. S. Zucker
Roles of Ca2+, Hyperpolarization and Cyclic Nucleotide-Activated Channel Activation, and Actin in Temporal Synaptic Tagging
J. Neurosci., April 28, 2004; 24(17): 4205 - 4212.
[Abstract] [Full Text] [PDF]
A. Bhattacharjee, W. J. Joiner, M. Wu, Y. Yang, F. J. Sigworth, and L. K. Kaczmarek
Slick (Slo2.1), a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATP
J. Neurosci., December 17, 2003; 23(37): 11681 - 11691.
[Abstract] [Full Text] [PDF]
F. Yang, X.-p. He, J. Russell, and B. Lu
Ca2+ influx-independent synaptic potentiation mediated by mitochondrial Na+-Ca2+ exchanger and protein kinase C
J. Cell Biol., November 10, 2003; 163(3): 511 - 523.
[Abstract] [Full Text] [PDF]
A. Omelchenko, R. Bouchard, H. D. Le, P. Choptiany, N. Visen, M. Hnatowich, and L. V. Hryshko
Inhibition of Canine (NCX1.1) and Drosophila (CALX1.1) Na+-Ca2+ Exchangers by 7-Chloro-3,5-dihydro-5-phenyl-1H-4,1-benzothiazepine-2-one (CGP-37157)
J. Pharmacol. Exp. Ther., September 1, 2003; 306(3): 1050 - 1057.
[Abstract] [Full Text] [PDF]
N. Rumpal and G. A. Lnenicka
Ca2+ Clearance at Growth Cones Produced by Crayfish Motor Axons in an Explant Culture
J Neurophysiol, June 1, 2003; 89(6): 3225 - 3234.
[Abstract] [Full Text] [PDF]
M. C. Chicka and E. E. Strehler
Alternative Splicing of the First Intracellular Loop of Plasma Membrane Ca2+-ATPase Isoform 2 Alters Its Membrane Targeting
J. Biol. Chem., May 9, 2003; 278(20): 18464 - 18470.
[Abstract] [Full Text] [PDF]
B. W. Bernstein and J. R. Bamburg
Actin-ATP Hydrolysis Is a Major Energy Drain for Neurons
J. Neurosci., January 1, 2003; 23(1): 1 - 6.
[Abstract] [Full Text] [PDF]
N. B. Pivovarova, L. D. Pozzo-Miller, J. Hongpaisan, and S. B. Andrews
Correlated Calcium Uptake and Release by Mitochondria and Endoplasmic Reticulum of CA3 Hippocampal Dendrites after Afferent Synaptic Stimulation
J. Neurosci., December 15, 2002; 22(24): 10653 - 10661.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|