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The Journal of Neuroscience, December 15, 2001, 21(24):9837-9843
Perceptual Correlates of Neural Representations Evoked by Odorant Enantiomers
Christiane Linster1, Brett A. Johnson2, Esther Yue1, Alix Morse1, Zhe Xu2, Edna E. Hingco2, Yoojin Choi2, Mark Choi2, Ahdy Messiha2, and Michael Leon2 1 Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, and 2 Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4550
Spatial activation patterns within the olfactory bulb are believed to contribute to the neural representation of odorants. In this study, we attempted to predict the perceptions of odorants from their evoked patterns of neural activity in the olfactory bulb. We first describe the glomerular activation patterns evoked by pairs of odorant enantiomers based on the uptake of [14C]2-deoxyglucose in the olfactory bulb glomerular layer. Using a standardized data matrix enabling the systematic comparison of these spatial odorant representations, we hypothesized that the degree of similarity among these representations would predict their perceptual similarity. The two enantiomers of carvone evoked overlapping but significantly distinct regions of glomerular activity; however, the activity patterns evoked by the enantiomers of limonene and of terpinen-4-ol were not statistically different from one another. Commensurate with these data, rats spontaneously discriminated between the enantiomers of carvone, but not between the enantiomers of limonene or terpinen-4-ol, in an olfactory habituation task designed to probe differences in olfactory perception.
Key words: olfactory coding; enantiomers; optical isomers; olfactory perception; neural representations; habituation; reinforcement learning; olfactory bulb; glomeruli
Copyright © 2001 Society for Neuroscience 0270-6474/01/21249837-07$05.00/0
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