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Previous Article | Next Article
The Journal of Neuroscience, February 1, 2001, 21(3):1033-1038
Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease
Peter Brown1, Antonio Oliviero2, Paolo Mazzone3, Angelo Insola3, Pietro Tonali2, and Vincenzo Di Lazzaro2 1 Medical Research Council Human Movement and Balance Unit, Institute of Neurology, London WCIN 3BG, United Kingdom, 2 Institute of Neurology, Università Cattolica, 00168 Rome, Italy, and 3 Operative Unit of Functional and Stereotactic Neurosurgery, Centro Traumatologico Ortopedico, "A. Alesini" Hospital, 00145 Rome, Italy
The extent of synchronization within and between the nuclei of the basal ganglia is unknown in Parkinson's disease. The question is an important one because synchronization will increase postsynaptic efficacy at subsequent projection targets. We simultaneously recorded local potentials (LPs) from the globus pallidus interna (GPi) and subthalamic nucleus (STN) in four awake patients after neurosurgery for Parkinson's disease. Nuclei from both sides were recorded in two patients so that a total of six ipsilateral GPi-STN LP recordings were made. Without medication, the power within and the coherence between the GPi and STN was dominated by activity with a frequency <30 Hz. Treatment with the dopamine precursor levodopa reduced the low-frequency activity and resulted in a new peak at ~70 Hz. This was evident in the power spectrum from STN and GPi and in the coherence between these nuclei. The phase relationship between the nuclei varied in a complex manner according to frequency band and the presence of exogenous dopaminergic stimulation. Synchronization of activity does occur between pallidum and STN, and its pattern is critically dependent on the level of dopaminergic activity.
Key words: globus pallidus interna; subthalamic nucleus; coherence; synchronization; Parkinson's disease; dopamine
Copyright © 2001 Society for Neuroscience 0270-6474/01/2131033-06$05.00/0
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