 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, February 1, 2001, 21(3):999-1006
Expression and Localization of Endothelin Receptors: Implications for the Involvement of Peripheral Glia in Nociception
James D. Pomonis, Scott D. Rogers, Christopher M. Peters, Joseph R. Ghilardi, and Patrick W. Mantyh Departments of Preventive Science, Neuroscience, and Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, and Veterans Affairs Medical Center, Minneapolis, Minnesota 55417
The endothelins (ETs) are peptides that have a diverse array of functions mediated by two receptor subtypes, the endothelin A receptor (ETAR) and the endothelin B receptor (ETBR). Pharmacological studies have suggested that in peripheral tissues, ETAR expression may play a role in signaling acute or neuropathic pain, whereas ETBR expression may be involved in the transmission of chronic inflammatory pain. To begin to define the mechanisms by which ET can drive nociceptive signaling, autoradiography and immunohistochemistry were used to examine the distribution of ETAR and ETBR in dorsal root ganglia (DRG) and peripheral nerve of the rat, rabbit, and monkey. In DRG and peripheral nerve, ETAR-immunoreactivity was present in a subset of small-sized peptidergic and nonpeptidergic sensory neurons and their axons and to a lesser extent in a subset of medium-sized sensory neurons. However, ETBR-immunoreactivity was not seen in DRG neurons or axons but rather in DRG satellite cells and nonmyelinating ensheathing Schwann cells. Thus, when ETs are released in peripheral tissues, they could act directly on ETAR-expressing sensory neurons and on ETBR-expressing DRG satellite cells or nonmyelinating Schwann cells. These data indicate that ETs can have direct, nociceptive effects on the peripheral sensory nervous system and that peripheral glia may be directly involved in signaling nociceptive events in peripheral tissues.
Key words: ensheathing Schwann cells; satellite cells; inflammatory pain; cancer pain; sensory neurons; endothelin
Copyright © 2001 Society for Neuroscience 0270-6474/01/213999-08$05.00/0
This article has been cited by other articles:
D. T. Hamamoto, S. G. Khasabov, D. M. Cain, and D. A. Simone
Tumor-Evoked Sensitization of C Nociceptors: A Role for Endothelin
J Neurophysiol, October 1, 2008; 100(4): 2300 - 2311.
[Abstract] [Full Text] [PDF]
H. Namazi
A Novel Use of Botulinum Toxin to Ameliorate Bone Cancer Pain
Ann. Surg. Oncol., April 1, 2008; 15(4): 1259 - 1260.
[Full Text] [PDF]
U. C. Kopp, M. Z. Cicha, and L. A. Smith
Differential effects of endothelin on activation of renal mechanosensory nerves: stimulatory in high-sodium diet and inhibitory in low-sodium diet
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1545 - R1556.
[Abstract] [Full Text] [PDF]
M. A. Carducci and A. Jimeno
Targeting bone metastasis in prostate cancer with endothelin receptor antagonists.
Clin. Cancer Res., October 15, 2006; 12(20): 6296s - 6300s.
[Abstract] [Full Text] [PDF]
J. G. Chichorro, A. R. Zampronio, and G. A. Rae
Endothelin ETB Receptor Antagonist Reduces Mechanical Allodynia in Rats with Trigeminal Neuropathic Pain.
Experimental Biology and Medicine, June 1, 2006; 231(6): 1136 - 1140.
[Abstract] [Full Text] [PDF]
T. D. Plant, C. Zollner, S. A. Mousa, and A. Oksche
Endothelin-1 Potentiates Capsaicin-Induced TRPV1 Currents Via the Endothelin A Receptor.
Experimental Biology and Medicine, June 1, 2006; 231(6): 1161 - 1164.
[Abstract] [Full Text] [PDF]
M. Klass, A. Hord, M. Wilcox, D. Denson, and M. Csete
A Role for Endothelin in Neuropathic Pain After Chronic Constriction Injury of the Sciatic Nerve
Anesth. Analg., December 1, 2005; 101(6): 1757 - 1762.
[Abstract] [Full Text] [PDF]
Y. Wang and D. H. Wang
Prevention of endothelin-1-induced increases in blood pressure: role of endogenous CGRP
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1868 - H1874.
[Abstract] [Full Text] [PDF]
R.-R. Ji and G. Strichartz
Cell Signaling and the Genesis of Neuropathic Pain
Sci. Signal., September 28, 2004; 2004(252): re14 - re14.
[Abstract] [Full Text] [PDF]
M. Fang, K. J Kovacs, L. L Fisher, and A. A Larson
Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin
J. Physiol., June 15, 2003; 549(3): 903 - 917.
[Abstract] [Full Text] [PDF]
E. Berggreen and K.J. Heyeraas
Role of K+ATP Channels, Endothelin A Receptors, and Effect of Angiotensin II on Blood Flow in Oral Tissues
Journal of Dental Research, January 1, 2003; 82(1): 33 - 37.
[Abstract] [Full Text] [PDF]
A. Khodorova, M. U. Fareed, A. Gokin, G. R. Strichartz, and G. Davar
Local Injection of a Selective Endothelin-B Receptor Agonist Inhibits Endothelin-1-Induced Pain-Like Behavior and Excitation of Nociceptors in a Naloxone-Sensitive Manner
J. Neurosci., September 1, 2002; 22(17): 7788 - 7796.
[Abstract] [Full Text] [PDF]
P. W. Wacnik, L. J. Eikmeier, T. R. Ruggles, M. L. Ramnaraine, B. K. Walcheck, A. J. Beitz, and G. L. Wilcox
Functional Interactions between Tumor and Peripheral Nerve: Morphology, Algogen Identification, and Behavioral Characterization of a New Murine Model of Cancer Pain
J. Neurosci., December 1, 2001; 21(23): 9355 - 9366.
[Abstract] [Full Text] [PDF]
A. P. Gokin, M. U. Fareed, H.-L. Pan, G. Hans, G. R. Strichartz, and G. Davar
Local Injection of Endothelin-1 Produces Pain-Like Behavior and Excitation of Nociceptors in Rats
J. Neurosci., July 15, 2001; 21(14): 5358 - 5366.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|