 |
 Previous Article | Next Article 
The Journal of Neuroscience, March 1, 2001, 21(5):1452-1463
Molecular and Physiological Diversity of Nicotinic Acetylcholine
Receptors in the Midbrain Dopaminergic Nuclei
Ruby
Klink1,
Alban
de Kerchove
d'Exaerde1,
Michele
Zoli1, 2, and
Jean-Pierre
Changeux1
1 Laboratoire de Neurobiologie Moléculaire,
Centre National de la Recherche Scientifique Unité de Recherche
Associée 2182 "Récepteurs et Cognition," Institut
Pasteur, 75724 Paris Cédex 15, France, and
2 Department of Biomedical Sciences, Section of Physiology,
University of Modena and Reggio Emilia, 41100 Modena, Italy
Nicotinic acetylcholine receptors (nAChRs) on dopaminergic (DA) and
GABAergic (Gaba) projection neurons of the substantia nigra (SN)
and ventral tegmental area (VTA) are characterized by single-cell
RT-PCR and patch-clamp recordings in slices of rat and wild-type,
 2 /,  4/, and 7/ mice. The eight nAChR subunits
expressed in these nuclei, 3-7 and 2-4, contribute to four
different types of nAChR-mediated currents. Most DA neurons in the SN
and VTA express two nAChR subtypes. One is inhibited by
dihydro--erythroidine (2 µM), -conotoxin MII (10 nM), and methyllycaconitine (1 nM) but does not
contain the 7 subunit; it possesses a putative
465(2)2 composition. The other subtype is
inhibited by dihydro--erythroidine (2 µM) and has a
putative 45(2)2 composition. Gaba neurons in the
VTA exhibit a third subtype with a putative
(4)2(2)3 composition, whereas Gaba
neurons in the SN have either the putative
(4)2(2)3 oligomer or the putative
465(2)2 oligomer. The fourth subtype, a
putative (7)5 homomer, is encountered in less than half
of DA and Gaba neurons, in the SN as well as in the VTA. Neurons in the
DA nuclei thus exhibit a diversity of nAChRs that might differentially
modulate reinforcement and motor behavior.
Key words:
addiction; dopamine; GABA; nAChR; nicotinic; Parkinson's
disease; substantia nigra; ventral tegmental area
Copyright © 2001 Society for Neuroscience 0270-6474/01/2151452-12$05.00/0
This article has been cited by other articles:
|
|
|
|
 
K. J. Jackson, J. M. McIntosh, D. H. Brunzell, S. S. Sanjakdar, and M. I. Damaj
The Role of {alpha}6-Containing Nicotinic Acetylcholine Receptors in Nicotine Reward and Withdrawal
J. Pharmacol. Exp. Ther.,
November 1, 2009;
331(2):
547 - 554.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Xiao, R. Nashmi, S. McKinney, H. Cai, J. M. McIntosh, and H. A. Lester
Chronic Nicotine Selectively Enhances {alpha}4{beta}2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway
J. Neurosci.,
October 7, 2009;
29(40):
12428 - 12439.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Tu, Z. Gu, J.-x. Shen, P. W. Lamb, and J. L. Yakel
Characterization of a Nicotine-Sensitive Neuronal Population in Rat Entorhinal Cortex
J. Neurosci.,
August 19, 2009;
29(33):
10436 - 10448.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ericson, E. Lof, R. Stomberg, and B. Soderpalm
The Smoking Cessation Medication Varenicline Attenuates Alcohol and Nicotine Interactions in the Rat Mesolimbic Dopamine System
J. Pharmacol. Exp. Ther.,
April 1, 2009;
329(1):
225 - 230.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. McClure-Begley, N. M. King, A. C. Collins, J. A. Stitzel, J. M. Wehner, and C. M. Butt
Acetylcholine-Stimulated [3H]GABA Release from Mouse Brain Synaptosomes is Modulated by {alpha}4{beta}2 and {alpha}4{alpha}5{beta}2 Nicotinic Receptor Subtypes
Mol. Pharmacol.,
April 1, 2009;
75(4):
918 - 926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. H. Good and C. R. Lupica
Properties of distinct ventral tegmental area synapses activated via pedunculopontine or ventral tegmental area stimulation in vitro
J. Physiol.,
March 15, 2009;
587(6):
1233 - 1247.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Zhu, S. Apparsundaram, and L. P. Dwoskin
Nicotinic Receptor Activation Increases [3H]Dopamine Uptake and Cell Surface Expression of Dopamine Transporters in Rat Prefrontal Cortex
J. Pharmacol. Exp. Ther.,
March 1, 2009;
328(3):
931 - 939.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Yang, J. Hu, L. Lucero, Q. Liu, C. Zheng, X. Zhen, G. Jin, R. J. Lukas, and J. Wu
Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons
J. Physiol.,
January 15, 2009;
587(2):
345 - 361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Pons, L. Fattore, G. Cossu, S. Tolu, E. Porcu, J. M. McIntosh, J. P. Changeux, U. Maskos, and W. Fratta
Crucial Role of {alpha}4 and {alpha}6 Nicotinic Acetylcholine Receptor Subunits from Ventral Tegmental Area in Systemic Nicotine Self-Administration
J. Neurosci.,
November 19, 2008;
28(47):
12318 - 12327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Innocent, P. D. Livingstone, A. Hone, A. Kimura, T. Young, P. Whiteaker, J. M. McIntosh, and S. Wonnacott
{alpha}Conotoxin Arenatus IB[V11L,V16D] Is a Potent and Selective Antagonist at Rat and Human Native {alpha}7 Nicotinic Acetylcholine Receptors
J. Pharmacol. Exp. Ther.,
November 1, 2008;
327(2):
529 - 537.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Avale, P. Faure, S. Pons, P. Robledo, T. Deltheil, D. J. David, A. M. Gardier, R. Maldonado, S. Granon, J.-P. Changeux, et al.
Interplay of {beta}2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion
PNAS,
October 14, 2008;
105(41):
15991 - 15996.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-B. You, B. Wang, D. Zitzman, and R. A. Wise
Acetylcholine Release in the Mesocorticolimbic Dopamine System during Cocaine Seeking: Conditioned and Unconditioned Contributions to Reward and Motivation
J. Neurosci.,
September 3, 2008;
28(36):
9021 - 9029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. P. Dwoskin, T. E. Wooters, S. P. Sumithran, K. B. Siripurapu, B. M. Joyce, P. R. Lockman, V. K. Manda, J. T. Ayers, Z. Zhang, A. G. Deaciuc, et al.
N,N'-Alkane-diyl-bis-3-picoliniums as Nicotinic Receptor Antagonists: Inhibition of Nicotine-Evoked Dopamine Release and Hyperactivity
J. Pharmacol. Exp. Ther.,
August 1, 2008;
326(2):
563 - 576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Guntz, H. Dumont, E. Pastijn, A. de Kerchove d'Exaerde, K. Azdad, M. Sosnowski, S. N. Schiffmann, and D. Gall
Expression of Adenosine A2A Receptors in the Rat Lumbar Spinal Cord and Implications in the Modulation of N-Methyl-d-Aspartate Receptor Currents
Anesth. Analg.,
June 1, 2008;
106(6):
1882 - 1889.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. V. Poisik, J.-x. Shen, S. Jones, and J. L. Yakel
Functional {alpha}7-containing nicotinic acetylcholine receptors localize to cell bodies and proximal dendrites in the rat substantia nigra pars reticulata
J. Physiol.,
March 1, 2008;
586(5):
1365 - 1378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Keath, M. P. Iacoviello, L. E. Barrett, H. D. Mansvelder, and D. S. McGehee
Differential Modulation by Nicotine of Substantia Nigra Versus Ventral Tegmental Area Dopamine Neurons
J Neurophysiol,
December 1, 2007;
98(6):
3388 - 3396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Zanardi, R. Ferrari, G. Leo, U. Maskos, J.-P. Changeux, and M. Zoli
Loss of high-affinity nicotinic receptors increases the vulnerability to excitotoxic lesion and decreases the positive effects of an enriched environment
FASEB J,
December 1, 2007;
21(14):
4028 - 4037.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Davis, J. W. Kenney, and T. J. Gould
Hippocampal {alpha}4{beta}2 Nicotinic Acetylcholine Receptor Involvement in the Enhancing Effect of Acute Nicotine on Contextual Fear Conditioning
J. Neurosci.,
October 3, 2007;
27(40):
10870 - 10877.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. M. Fagen, R. Mitchum, P. Vezina, and D. S. McGehee
Enhanced Nicotinic Receptor Function and Drug Abuse Vulnerability
J. Neurosci.,
August 15, 2007;
27(33):
8771 - 8778.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Addy, E. F. Fornasiero, T. R. Stevens, J. R. Taylor, and M. R. Picciotto
Role of Calcineurin in Nicotine-Mediated Locomotor Sensitization
J. Neurosci.,
August 8, 2007;
27(32):
8571 - 8580.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Nashmi, C. Xiao, P. Deshpande, S. McKinney, S. R. Grady, P. Whiteaker, Q. Huang, T. McClure-Begley, J. M. Lindstrom, C. Labarca, et al.
Chronic Nicotine Cell Specifically Upregulates Functional {alpha}4* Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path
J. Neurosci.,
August 1, 2007;
27(31):
8202 - 8218.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Salminen, J. A. Drapeau, J. M. McIntosh, A. C. Collins, M. J. Marks, and S. R. Grady
Pharmacology of {alpha}-Conotoxin MII-Sensitive Subtypes of Nicotinic Acetylcholine Receptors Isolated by Breeding of Null Mutant Mice
Mol. Pharmacol.,
June 1, 2007;
71(6):
1563 - 1571.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-P. Changeux
The Ferrier Lecture 1998 The molecular biology of consciousness investigated with genetically modified mice
Phil Trans R Soc B,
December 29, 2006;
361(1476):
2239 - 2259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. S. McGehee
Nicotinic and Opioid Receptor Interactions in Nicotine Addiction
Mol. Interv.,
December 1, 2006;
6(6):
311 - 314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Klein and J. L. Yakel
Functional somato-dendritic {alpha}7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complex
J. Physiol.,
November 1, 2006;
576(3):
865 - 872.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wu, Q. Liu, K. Yu, J. Hu, Y.-P. Kuo, M. Segerberg, P. A. St John, and R. J. Lukas
Roles of nicotinic acetylcholine receptor {beta} subunits in function of human {alpha}4-containing nicotinic receptors
J. Physiol.,
October 1, 2006;
576(1):
103 - 118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. JERLHAG, M. GROTLI, K. LUTHMAN, L. SVENSSON, and J. A. ENGEL
ROLE OF THE SUBUNIT COMPOSITION OF CENTRAL NICOTINIC ACETYLCHOLINE RECEPTORS FOR THE STIMULATORY AND DOPAMINE-ENHANCING EFFECTS OF ETHANOL
Alcohol Alcohol.,
September 1, 2006;
41(5):
486 - 493.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. McCallum, N. Parameswaran, T. Bordia, H. Fan, J. M. McIntosh, and M. Quik
Differential Regulation of Mesolimbic {alpha}3/{alpha}6beta2 and {alpha}4beta2 Nicotinic Acetylcholine Receptor Sites and Function after Long-Term Oral Nicotine to Monkeys
J. Pharmacol. Exp. Ther.,
July 1, 2006;
318(1):
381 - 388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Quik and J. M. McIntosh
Striatal {alpha}6* Nicotinic Acetylcholine Receptors: Potential Targets for Parkinson's Disease Therapy
J. Pharmacol. Exp. Ther.,
February 1, 2006;
316(2):
481 - 489.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Zhu, R. R. Stewart, J. M. McIntosh, and F. F. Weight
Activation of Nicotinic Acetylcholine Receptors Increases the Frequency of Spontaneous GABAergic IPSCs in Rat Basolateral Amygdala Neurons
J Neurophysiol,
November 1, 2005;
94(5):
3081 - 3091.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Zhang, Y. Liu, and X. Chen
Carbachol induces burst firing of dopamine cells in the ventral tegmental area by promoting calcium entry through L-type channels in the rat
J. Physiol.,
October 15, 2005;
568(2):
469 - 481.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. McCallum, N. Parameswaran, T. Bordia, J. M. McIntosh, S. R. Grady, and M. Quik
Decrease in {alpha}3*/{alpha}6* Nicotinic Receptors but Not Nicotine-Evoked Dopamine Release in Monkey Brain after Nigrostriatal Damage
Mol. Pharmacol.,
September 1, 2005;
68(3):
737 - 746.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. E. Strang, M. E. Andison, F. R. Amthor, and K. T. Keyser
Rabbit retinal ganglion cells express functional {alpha}7 nicotinic acetylcholine receptors
Am J Physiol Cell Physiol,
September 1, 2005;
289(3):
C644 - C655.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Koyama, Y. Kanemitsu, and F. F. Weight
Spontaneous Activity and Properties of Two Types of Principal Neurons From the Ventral Tegmental Area of Rat
J Neurophysiol,
June 1, 2005;
93(6):
3282 - 3293.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gotti, M. Moretti, F. Clementi, L. Riganti, J. M. McIntosh, A. C. Collins, M. J. Marks, and P. Whiteaker
Expression of Nigrostriatal {alpha}6-Containing Nicotinic Acetylcholine Receptors Is Selectively Reduced, but Not Eliminated, by {beta}3 Subunit Gene Deletion
Mol. Pharmacol.,
June 1, 2005;
67(6):
2007 - 2015.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-J. Cao, C. S. Surowy, and P. S. Puttfarcken
Nicotinic Acetylcholine Receptor-Mediated [3H]Dopamine Release from Hippocampus
J. Pharmacol. Exp. Ther.,
March 1, 2005;
312(3):
1298 - 1304.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. P. Grinevich, S. R. Letchworth, K. A. Lindenberger, J. Menager, V. Mary, K. A. Sadieva, L. M. Buhlman, G. A. Bohme, L. Pradier, J. Benavides, et al.
Heterologous Expression of Human {alpha}6{beta}4{beta}3{alpha}5 Nicotinic Acetylcholine Receptors: Binding Properties Consistent with Their Natural Expression Require Quaternary Subunit Assembly Including the {alpha}5 Subunit
J. Pharmacol. Exp. Ther.,
February 1, 2005;
312(2):
619 - 626.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Azam and J. M. McIntosh
Effect of Novel {alpha}-Conotoxins on Nicotine-Stimulated [3H]Dopamine Release from Rat Striatal Synaptosomes
J. Pharmacol. Exp. Ther.,
January 1, 2005;
312(1):
231 - 237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Quik, S. Vailati, T. Bordia, J. M. Kulak, H. Fan, J. M. McIntosh, F. Clementi, and C. Gotti
Subunit Composition of Nicotinic Receptors in Monkey Striatum: Effect of Treatments with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA
Mol. Pharmacol.,
January 1, 2005;
67(1):
32 - 41.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. W. Jones and S. Wonnacott
Precise Localization of {alpha}7 Nicotinic Acetylcholine Receptors on Glutamatergic Axon Terminals in the Rat Ventral Tegmental Area
J. Neurosci.,
December 15, 2004;
24(50):
11244 - 11252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Turner
Nicotine Enhancement of Dopamine Release by a Calcium-Dependent Increase in the Size of the Readily Releasable Pool of Synaptic Vesicles
J. Neurosci.,
December 15, 2004;
24(50):
11328 - 11336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Salas, F. Pieri, and M. De Biasi
Decreased Signs of Nicotine Withdrawal in Mice Null for the {beta}4 Nicotinic Acetylcholine Receptor Subunit
J. Neurosci.,
November 10, 2004;
24(45):
10035 - 10039.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wu, A. A. George, K. M. Schroeder, L. Xu, S. Marxer-Miller, L. Lucero, and R. J. Lukas
Electrophysiological, Pharmacological, and Molecular Evidence for {alpha}7-Nicotinic Acetylcholine Receptors in Rat Midbrain Dopamine Neurons
J. Pharmacol. Exp. Ther.,
October 1, 2004;
311(1):
80 - 91.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Orb, J. Wieacker, C. Labarca, C. Fonck, H. A. Lester, and J. Schwarz
Knockin mice with Leu9'Ser {alpha}4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally
Physiol Genomics,
August 11, 2004;
18(3):
299 - 307.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Lena, D. Popa, R. Grailhe, P. Escourrou, J.-P. Changeux, and J. Adrien
{beta}2-Containing Nicotinic Receptors Contribute to the Organization of Sleep and Regulate Putative Micro-Arousals in Mice
J. Neurosci.,
June 23, 2004;
24(25):
5711 - 5718.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Luetje
Getting Past the Asterisk: the Subunit Composition of Presynaptic Nicotinic Receptors That Modulate Striatal Dopamine Release
Mol. Pharmacol.,
June 1, 2004;
65(6):
1333 - 1335.
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Salminen, K. L. Murphy, J. M. McIntosh, J. Drago, M. J. Marks, A. C. Collins, and S. R. Grady
Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice
Mol. Pharmacol.,
June 1, 2004;
65(6):
1526 - 1535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Wehrwein, S. A. Thompson, S. F. Coulibaly, D. M. Linn, and C. L. Linn
Acetylcholine Protection of Adult Pig Retinal Ganglion Cells from Glutamate-Induced Excitotoxicity
Invest. Ophthalmol. Vis. Sci.,
May 1, 2004;
45(5):
1531 - 1543.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Michel, J. M. Robillard, and L.-E. Trudeau
Regulation of rat mesencephalic GABAergic neurones through muscarinic receptors
J. Physiol.,
April 15, 2004;
556(2):
429 - 445.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kedmi, A. L. Beaudet, and A. Orr-Urtreger
Mice lacking neuronal nicotinic acetylcholine receptor {beta}4-subunit and mice lacking both {alpha}5- and {beta}4-subunits are highly resistant to nicotine-induced seizures
Physiol Genomics,
April 13, 2004;
17(2):
221 - 229.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pierucci, V. Di Matteo, and E. Esposito
Stimulation of Serotonin2C Receptors Blocks the Hyperactivation of Midbrain Dopamine Neurons Induced by Nicotine Administration
J. Pharmacol. Exp. Ther.,
April 1, 2004;
309(1):
109 - 118.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
V. B. Kane, Y. Fu, S. G. Matta, and B. M. Sharp
Gestational Nicotine Exposure Attenuates Nicotine-Stimulated Dopamine Release in the Nucleus Accumbens Shell of Adolescent Lewis Rats
J. Pharmacol. Exp. Ther.,
February 1, 2004;
308(2):
521 - 528.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. I. Pidoplichko, J. Noguchi, O. O. Areola, Y. Liang, J. Peterson, T. Zhang, and J. A. Dani
Nicotinic Cholinergic Synaptic Mechanisms in the Ventral Tegmental Area Contribute to Nicotine Addiction
Learn. Mem.,
January 1, 2004;
11(1):
60 - 69.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Middleton, W. A. Cass, and L. P. Dwoskin
Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex
J. Pharmacol. Exp. Ther.,
January 1, 2004;
308(1):
367 - 377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Nashmi, M. E. Dickinson, S. McKinney, M. Jareb, C. Labarca, S. E. Fraser, and H. A. Lester
Assembly of {alpha}4{beta}2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons
J. Neurosci.,
December 17, 2003;
23(37):
11554 - 11567.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Cui, T. K. Booker, R. S. Allen, S. R. Grady, P. Whiteaker, M. J. Marks, O. Salminen, T. Tritto, C. M. Butt, W. R. Allen, et al.
The {beta}3 Nicotinic Receptor Subunit: A Component of {alpha}-Conotoxin MII-Binding Nicotinic Acetylcholine Receptors that Modulate Dopamine Release and Related Behaviors
J. Neurosci.,
December 3, 2003;
23(35):
11045 - 11053.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. N. Nguyen, B. A. Rasmussen, and D. C. Perry
Subtype-Selective Up-Regulation by Chronic Nicotine of High-Affinity Nicotinic Receptors in Rat Brain Demonstrated by Receptor Autoradiography
J. Pharmacol. Exp. Ther.,
December 1, 2003;
307(3):
1090 - 1097.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Dowell, B. M. Olivera, J. E. Garrett, S. T. Staheli, M. Watkins, A. Kuryatov, D. Yoshikami, J. M. Lindstrom, and J. M. McIntosh
{alpha}-Conotoxin PIA Is Selective for {alpha}6 Subunit-Containing Nicotinic Acetylcholine Receptors
J. Neurosci.,
September 17, 2003;
23(24):
8445 - 8452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Quik, T. Bordia, M. Okihara, H. Fan, M. J. Marks, J. M. McIntosh, and P. Whiteaker
L-DOPA Treatment Modulates Nicotinic Receptors in Monkey Striatum
Mol. Pharmacol.,
September 1, 2003;
64(3):
619 - 628.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. P. Grinevich, P. A. Crooks, S. P. Sumithran, A. J. Haubner, J. T. Ayers, and L. P. Dwoskin
N-n-Alkylpyridinium Analogs, a Novel Class of Nicotinic Receptor Antagonists: Selective Inhibition of Nicotine-Evoked [3H]Dopamine Overflow from Superfused Rat Striatal Slices
J. Pharmacol. Exp. Ther.,
September 1, 2003;
306(3):
1011 - 1020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Champtiaux, C. Gotti, M. Cordero-Erausquin, D. J. David, C. Przybylski, C. Lena, F. Clementi, M. Moretti, F. M. Rossi, N. Le Novere, et al.
Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice
J. Neurosci.,
August 27, 2003;
23(21):
7820 - 7829.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Adriani, S. Spijker, V. Deroche-Gamonet, G. Laviola, M. Le Moal, A. B. Smit, and P. V. Piazza
Evidence for Enhanced Neurobehavioral Vulnerability to Nicotine during Periadolescence in Rats
J. Neurosci.,
June 1, 2003;
23(11):
4712 - 4716.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Salas, A. Orr-Urtreger, R. S. Broide, A. Beaudet, R. Paylor, and M. De Biasi
The Nicotinic Acetylcholine Receptor Subunit alpha 5 Mediates Short-Term Effects of Nicotine in Vivo
Mol. Pharmacol.,
May 1, 2003;
63(5):
1059 - 1066.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. A. Wooltorton, V. I. Pidoplichko, R. S. Broide, and J. A. Dani
Differential Desensitization and Distribution of Nicotinic Acetylcholine Receptor Subtypes in Midbrain Dopamine Areas
J. Neurosci.,
April 15, 2003;
23(8):
3176 - 3185.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sahibzada, M. Ferreira Jr, B. Williams, A. Wasserman, S. Vicini, and R. A Gillis
Nicotinic ACh receptor subtypes on gastrointestinally projecting neurones in the dorsal motor vagal nucleus of the rat
J. Physiol.,
December 15, 2002;
545(3):
1007 - 1016.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. M. Khan, E. Singletary, A. Alemayehu, S. Stanislaus, M. P. Printz, T. L. Yaksh, and P. Taylor
Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness
Physiol Genomics,
October 29, 2002;
11(2):
65 - 72.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Zoli, M. Moretti, A. Zanardi, J. M. McIntosh, F. Clementi, and C. Gotti
Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum
J. Neurosci.,
October 15, 2002;
22(20):
8785 - 8789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. M. Shao and J. L. Feldman
Pharmacology of Nicotinic Receptors in PreBotzinger Complex That Mediate Modulation of Respiratory Pattern
J Neurophysiol,
October 1, 2002;
88(4):
1851 - 1858.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Christophe, A. Roebuck, J. F. Staiger, D. J. Lavery, S. Charpak, and E. Audinat
Two Types of Nicotinic Receptors Mediate an Excitation of Neocortical Layer I Interneurons
J Neurophysiol,
September 1, 2002;
88(3):
1318 - 1327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Mogg, P. Whiteaker, J. M. McIntosh, M. Marks, A. C. Collins, and S. Wonnacott
Methyllycaconitine Is a Potent Antagonist of alpha -Conotoxin-MII-Sensitive Presynaptic Nicotinic Acetylcholine Receptors in Rat Striatum
J. Pharmacol. Exp. Ther.,
July 1, 2002;
302(1):
197 - 204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. Grady, K. L. Murphy, J. Cao, M. J. Marks, J. M. McIntosh, and A. C. Collins
Characterization of Nicotinic Agonist-Induced [3H]Dopamine Release from Synaptosomes Prepared from Four Mouse Brain Regions
J. Pharmacol. Exp. Ther.,
May 1, 2002;
301(2):
651 - 660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Picciotto and W. A. Corrigall
Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics
J. Neurosci.,
May 1, 2002;
22(9):
3338 - 3341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Whiteaker, C. G. Peterson, W. Xu, J. M. McIntosh, R. Paylor, A. L. Beaudet, A. C. Collins, and M. J. Marks
Involvement of the alpha 3 Subunit in Central Nicotinic Binding Populations
J. Neurosci.,
April 1, 2002;
22(7):
2522 - 2529.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Champtiaux, Z.-Y. Han, A. Bessis, F. M. Rossi, M. Zoli, L. Marubio, J. M. McIntosh, and J.-P. Changeux
Distribution and Pharmacology of alpha 6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice
J. Neurosci.,
February 15, 2002;
22(4):
1208 - 1217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Neuhoff, A. Neu, B. Liss, and J. Roeper
Ih Channels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain
J. Neurosci.,
February 15, 2002;
22(4):
1290 - 1302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kawa
Acute synaptic modulation by nicotinic agonists in developing cerebellar Purkinje cells of the rat
J. Physiol.,
January 1, 2002;
538(1):
87 - 102.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kawa
Acute synaptic modulation by nicotinic agonists in developing cerebellar Purkinje cells of the rat
J. Physiol.,
January 1, 2002;
538(1):
87 - 102.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
