 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, March 1, 2001, 21(5):1676-1697
Correlated Firing in Macaque Visual Area MT: Time Scales and Relationship to Behavior
Wyeth Bair1, 2, Ehud Zohary3, and William T. Newsome1, 4 1 Howard Hughes Medical Institute (HHMI), 2 Center for Neural Science, New York University, New York, New York 10003, 3 Department of Neurobiology, Institute of Life Science, Hebrew University, Jerusalem, 91904, Israel, and 4 Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305
We studied the simultaneous activity of pairs of neurons recorded with a single electrode in visual cortical area MT while monkeys performed a direction discrimination task. Previously, we reported the strength of interneuronal correlation of spike count on the time scale of the behavioral epoch (2 sec) and noted its potential impact on signal pooling (Zohary et al., 1994). We have now examined correlation at longer and shorter time scales and found that pair-wise cross-correlation was predominantly short term (10-100 msec). Narrow, central peaks in the spike train cross-correlograms were largely responsible for correlated spike counts on the time scale of the behavioral epoch. Longer-term (many seconds to minutes) changes in the responsiveness of single neurons were observed in auto-correlations; however, these slow changes in time were on average uncorrelated between neurons. Knowledge of the limited time scale of correlation allowed the derivation of a more efficient metric for spike count correlation based on spike timing information, and it also revealed a potential relative advantage of larger neuronal pools for shorter integration times. Finally, correlation did not depend on the presence of the visual stimulus or the behavioral choice of the animal. It varied little with stimulus condition but was stronger between neurons with similar direction tuning curves. Taken together, our results strengthen the view that common input, common stimulus selectivity, and common noise are tightly linked in functioning cortical circuits.
Key words: Area MT/V5; cross-correlation; neuronal pooling; visual motion; extrastriate cortex; synchrony; stimulus-locked modulation; noise correlation; visual cortex
Copyright © 2001 Society for Neuroscience 0270-6474/01/2151676-22$05.00/0
This article has been cited by other articles:
L. C. Osborne and S. G. Lisberger
Spatial and Temporal Integration of Visual Motion Signals for Smooth Pursuit Eye Movements in Monkeys
J Neurophysiol, October 1, 2009; 102(4): 2013 - 2025.
[Abstract] [Full Text] [PDF]
S. Ostojic, N. Brunel, and V. Hakim
How Connectivity, Background Activity, and Synaptic Properties Shape the Cross-Correlation between Spike Trains
J. Neurosci., August 19, 2009; 29(33): 10234 - 10253.
[Abstract] [Full Text] [PDF]
X. Huang and S. G. Lisberger
Noise Correlations in Cortical Area MT and Their Potential Impact on Trial-by-Trial Variation in the Direction and Speed of Smooth-Pursuit Eye Movements
J Neurophysiol, June 1, 2009; 101(6): 3012 - 3030.
[Abstract] [Full Text] [PDF]
M. R. Cohen and W. T. Newsome
Estimates of the Contribution of Single Neurons to Perception Depend on Timescale and Noise Correlation
J. Neurosci., May 20, 2009; 29(20): 6635 - 6648.
[Abstract] [Full Text] [PDF]
T. M. Herrington, N. Y. Masse, K. J. Hachmeh, J. E. T. Smith, J. A. Assad, and E. P. Cook
The Effect of Microsaccades on the Correlation between Neural Activity and Behavior in Middle Temporal, Ventral Intraparietal, and Lateral Intraparietal Areas
J. Neurosci., May 6, 2009; 29(18): 5793 - 5805.
[Abstract] [Full Text] [PDF]
W. J. Jermakowicz, X. Chen, I. Khaytin, A. B. Bonds, and V. A. Casagrande
Relationship Between Spontaneous and Evoked Spike-Time Correlations in Primate Visual Cortex
J Neurophysiol, May 1, 2009; 101(5): 2279 - 2289.
[Abstract] [Full Text] [PDF]
J. Yang and S. G. Lisberger
Relationship Between Adapted Neural Population Responses in MT and Motion Adaptation in Speed and Direction of Smooth-Pursuit Eye Movements
J Neurophysiol, May 1, 2009; 101(5): 2693 - 2707.
[Abstract] [Full Text] [PDF]
G. M. Ghose and I. T. Harrison
Temporal Precision of Neuronal Information in a Rapid Perceptual Judgment
J Neurophysiol, March 1, 2009; 101(3): 1480 - 1493.
[Abstract] [Full Text] [PDF]
J. Poort and P. R. Roelfsema
Noise Correlations Have Little Influence on the Coding of Selective Attention in Area V1
Cereb Cortex, March 1, 2009; 19(3): 543 - 553.
[Abstract] [Full Text] [PDF]
L. C. Osborne, S. E. Palmer, S. G. Lisberger, and W. Bialek
The Neural Basis for Combinatorial Coding in a Cortical Population Response
J. Neurosci., December 10, 2008; 28(50): 13522 - 13531.
[Abstract] [Full Text] [PDF]
J. C. Dahmen, D. E. H. Hartley, and A. J. King
Stimulus-Timing-Dependent Plasticity of Cortical Frequency Representation
J. Neurosci., December 10, 2008; 28(50): 13629 - 13639.
[Abstract] [Full Text] [PDF]
S. Tsujimoto, A. Genovesio, and S. P. Wise
Transient Neuronal Correlations Underlying Goal Selection and Maintenance in Prefrontal Cortex
Cereb Cortex, December 1, 2008; 18(12): 2748 - 2761.
[Abstract] [Full Text] [PDF]
M. A. Smith and A. Kohn
Spatial and Temporal Scales of Neuronal Correlation in Primary Visual Cortex
J. Neurosci., November 26, 2008; 28(48): 12591 - 12603.
[Abstract] [Full Text] [PDF]
E. Lottem and R. Azouz
Dynamic Translation of Surface Coarseness Into Whisker Vibrations
J Neurophysiol, November 1, 2008; 100(5): 2852 - 2865.
[Abstract] [Full Text] [PDF]
Y. Chen, W. S. Geisler, and E. Seidemann
Optimal Temporal Decoding of Neural Population Responses in a Reaction-Time Visual Detection Task
J Neurophysiol, March 1, 2008; 99(3): 1366 - 1379.
[Abstract] [Full Text] [PDF]
S. S. Shaevitz and F. E. Theunissen
Functional Connectivity Between Auditory Areas Field L and CLM and Song System Nucleus HVC in Anesthetized Zebra Finches
J Neurophysiol, November 1, 2007; 98(5): 2747 - 2764.
[Abstract] [Full Text] [PDF]
A. Nevet, G. Morris, G. Saban, D. Arkadir, and H. Bergman
Lack of Spike-Count and Spike-Time Correlations in the Substantia Nigra Reticulata Despite Overlap of Neural Responses
J Neurophysiol, October 1, 2007; 98(4): 2232 - 2243.
[Abstract] [Full Text] [PDF]
H. Seo, D. J. Barraclough, and D. Lee
Dynamic Signals Related to Choices and Outcomes in the Dorsolateral Prefrontal Cortex
Cereb Cortex, September 1, 2007; 17(suppl_1): i110 - i117.
[Abstract] [Full Text] [PDF]
S. B. Hamed, M. H. Schieber, and A. Pouget
Decoding M1 Neurons During Multiple Finger Movements
J Neurophysiol, July 1, 2007; 98(1): 327 - 333.
[Abstract] [Full Text] [PDF]
A. Vogel and B. Ronacher
Neural Correlations Increase Between Consecutive Processing Levels in the Auditory System of Locusts
J Neurophysiol, May 1, 2007; 97(5): 3376 - 3385.
[Abstract] [Full Text] [PDF]
M. Siegel, T. H. Donner, R. Oostenveld, P. Fries, and A. K. Engel
High-Frequency Activity in Human Visual Cortex Is Modulated by Visual Motion Strength
Cereb Cortex, March 1, 2007; 17(3): 732 - 741.
[Abstract] [Full Text] [PDF]
F. Montani, A. Kohn, M. A. Smith, and S. R. Schultz
The Role of Correlations in Direction and Contrast Coding in the Primary Visual Cortex
J. Neurosci., February 28, 2007; 27(9): 2338 - 2348.
[Abstract] [Full Text] [PDF]
H. Nienborg and B. G. Cumming
Macaque v2 neurons, but not v1 neurons, show choice-related activity.
J. Neurosci., September 13, 2006; 26(37): 9567 - 9578.
[Abstract] [Full Text] [PDF]
P. J. Drew and L. F. Abbott
Extending the effects of spike-timing-dependent plasticity to behavioral timescales
PNAS, June 6, 2006; 103(23): 8876 - 8881.
[Abstract] [Full Text] [PDF]
P. Miller and X.-J. Wang
Power-Law Neuronal Fluctuations in a Recurrent Network Model of Parametric Working Memory
J Neurophysiol, February 1, 2006; 95(2): 1099 - 1114.
[Abstract] [Full Text] [PDF]
C. van der Togt, S. Kalitzin, H. Spekreijse, V. A.F. Lamme, and H. Super
Synchrony Dynamics in Monkey V1 Predict Success in Visual Detection
Cereb Cortex, January 1, 2006; 16(1): 136 - 148.
[Abstract] [Full Text] [PDF]
A. C. Huk and M. N. Shadlen
Neural Activity in Macaque Parietal Cortex Reflects Temporal Integration of Visual Motion Signals during Perceptual Decision Making
J. Neurosci., November 9, 2005; 25(45): 10420 - 10436.
[Abstract] [Full Text] [PDF]
H. Nover, C. H. Anderson, and G. C. DeAngelis
A Logarithmic, Scale-Invariant Representation of Speed in Macaque Middle Temporal Area Accounts for Speed Discrimination Performance
J. Neurosci., October 26, 2005; 25(43): 10049 - 10060.
[Abstract] [Full Text] [PDF]
P. Pouget, E. E. Emeric, V. Stuphorn, K. Reis, and J. D. Schall
Chronometry of Visual Responses in Frontal Eye Field, Supplementary Eye Field, and Anterior Cingulate Cortex
J Neurophysiol, September 1, 2005; 94(3): 2086 - 2092.
[Abstract] [Full Text] [PDF]
N. S. Narayanan, E. Y. Kimchi, and M. Laubach
Redundancy and Synergy of Neuronal Ensembles in Motor Cortex
J. Neurosci., April 27, 2005; 25(17): 4207 - 4216.
[Abstract] [Full Text] [PDF]
A. Kohn and M. A. Smith
Stimulus Dependence of Neuronal Correlation in Primary Visual Cortex of the Macaque
J. Neurosci., April 6, 2005; 25(14): 3661 - 3673.
[Abstract] [Full Text] [PDF]
J. Liu and W. T. Newsome
Correlation between Speed Perception and Neural Activity in the Middle Temporal Visual Area
J. Neurosci., January 19, 2005; 25(3): 711 - 722.
[Abstract] [Full Text] [PDF]
K. Ganguly and D. Kleinfeld
Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat
PNAS, August 17, 2004; 101(33): 12348 - 12353.
[Abstract] [Full Text] [PDF]
L. C. Osborne, W. Bialek, and S. G. Lisberger
Time Course of Information about Motion Direction in Visual Area MT of Macaque Monkeys
J. Neurosci., March 31, 2004; 24(13): 3210 - 3222.
[Abstract] [Full Text] [PDF]
Y. Prut and S. I. Perlmutter
Firing Properties of Spinal Interneurons during Voluntary Movement. II. Interactions between Spinal Neurons
J. Neurosci., October 22, 2003; 23(29): 9611 - 9619.
[Abstract] [Full Text] [PDF]
B. B. Averbeck and D. Lee
Neural Noise and Movement-Related Codes in the Macaque Supplementary Motor Area
J. Neurosci., August 20, 2003; 23(20): 7630 - 7641.
[Abstract] [Full Text] [PDF]
R. R. Kimpo, F. E. Theunissen, and A. J. Doupe
Propagation of Correlated Activity through Multiple Stages of a Neural Circuit
J. Neurosci., July 2, 2003; 23(13): 5750 - 5761.
[Abstract] [Full Text] [PDF]
J. D. Dorn and D. L. Ringach
Estimating Membrane Voltage Correlations From Extracellular Spike Trains
J Neurophysiol, April 1, 2003; 89(4): 2271 - 2278.
[Abstract] [Full Text] [PDF]
D. Lee and S. Quessy
Activity in the Supplementary Motor Area Related to Learning and Performance During a Sequential Visuomotor Task
J Neurophysiol, February 1, 2003; 89(2): 1039 - 1056.
[Abstract] [Full Text] [PDF]
D. Zoccolan, G. Pinato, and V. Torre
Highly Variable Spike Trains Underlie Reproducible Sensorimotor Responses in the Medicinal Leech
J. Neurosci., December 15, 2002; 22(24): 10790 - 10800.
[Abstract] [Full Text] [PDF]
C. Constantinidis and P. S. Goldman-Rakic
Correlated Discharges Among Putative Pyramidal Neurons and Interneurons in the Primate Prefrontal Cortex
J Neurophysiol, December 1, 2002; 88(6): 3487 - 3497.
[Abstract] [Full Text] [PDF]
R. Krahe, G. Kreiman, F. Gabbiani, C. Koch, and W. Metzner
Stimulus Encoding and Feature Extraction by Multiple Sensory Neurons
J. Neurosci., March 15, 2002; 22(6): 2374 - 2382.
[Abstract] [Full Text] [PDF]
D. B. Katz, S. A. Simon, and M. A. L. Nicolelis
Taste-Specific Neuronal Ensembles in the Gustatory Cortex of Awake Rats
J. Neurosci., March 1, 2002; 22(5): 1850 - 1857.
[Abstract] [Full Text] [PDF]
D. S. Reich, F. Mechler, and J. D. Victor
Independent and Redundant Information in Nearby Cortical Neurons
Science, December 21, 2001; 294(5551): 2566 - 2568.
[Abstract] [Full Text] [PDF]
C. Constantinidis, M. N. Franowicz, and P. S. Goldman-Rakic
Coding Specificity in Cortical Microcircuits: A Multiple-Electrode Analysis of Primate Prefrontal Cortex
J. Neurosci., May 15, 2001; 21(10): 3646 - 3655.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|