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The Journal of Neuroscience, 2001, 21:RC132:1-5

RAPID COMMUNICATION
Pax-6 Regulates Expression of SFRP-2 and Wnt-7b in the Developing CNS

Anthony S. Kim¹, Stewart A. Anderson², John L. R. Rubenstein², Daniel H. Lowenstein³, and Samuel J. Pleasure¹

¹ Neurodevelopmental Disorders Laboratory, Department of Neurology, and ² Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, California 94143, and ³ Program in Brain Plasticity and Epileptogenesis, Harvard Medical School, and Department of Neurology, Beth Israel-Deaconess Medical Center, Boston, Massachusetts 02115

Wnt signaling regulates a wide range of developmental processes such as proliferation, cell migration, axon guidance, and cell fate determination. In this report, we studied the expression of secreted frizzled related protein-2 (SFRP-2), which codes for a putative Wnt inhibitor, in the developing nervous system. SFRP-2 is expressed in several discrete neuroepithelial domains, including the diencephalon, the insertion of the eminentia thalami into the caudal telencephalon, and the pallial-subpallial boundary (PSB). We also noted that Wnt-7b expression was similar to SFRP-2 expression. Because many of these structures are disrupted in Pax-6 mutant mice, we examined SFRP-2 and Wnt-7b expression in the forebrains of Pax-6 Sey/Sey mice. We found that Pax-6 mutants lack SFRP-2 expression in the PSB and diencephalon. Interestingly, Pax-6 mutants also lack Wnt-7b expression in the PSB, but Wnt-7b expression in the diencephalon is preserved. Furthermore, in the spinal cord of Pax-6 mutants, SFRP-2 and Wnt-7b expression was greatly reduced. Our results suggest that by virtue of its apposition to Wnt-7b expression, SFRP-2 may modulate its function, particularly at boundaries such as the PSB, and that changes in Wnt signaling contribute to the phenotype of Pax-6 mutants.

Key words: pallial-subpallial boundary; zona limitans intrathalamica; SFRP-2; Wnt-7b; Pax-6; small eyes (Sey); prosomere; lateral ganglionic eminence; caudal ganglionic eminence; eminentia thalami

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Copyright © Society for Neuroscience  0270-6474//$05.00/0

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