QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Hirata, T. Articles by Rao, Y. Search for Related Content PubMed PubMed Citation Articles by Hirata, T. Articles by Rao, Y.

 Previous Article  |  Next Article 

The Journal of Neuroscience, April 1, 2001, 21(7):2373-2379

Short-Range Guidance of Olfactory Bulb Axons Is Independent of Repulsive Factor Slit

Tatsumi Hirata^{1, 2, 3}, Hajime Fujisawa^{3, 4}, Jane Y. Wu⁵, and Yi Rao⁶

¹ Division of Brain Function, National Institute of Genetics, Mishima 411-8540, Japan, ² Precursory Research for Embryonic Science and Technology and ³ Core Research for Evolution Science and Technology, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan, ⁴ Division of Biological Science, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, Japan, ⁵ Departments of Pediatrics and Molecular Biology and Pharmacology, and ⁶ Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110

During development, mitral cells, the major output neurons of the olfactory bulb, project their axons caudolaterally into the telencephalon and form the lateral olfactory tract (LOT). Two types of guidance cues have been suggested for this projection. First, a long-range factor Slit, which is secreted from the septum, repels mitral cell axons into a caudolateral direction. Second, the pathway of mitral cell axons contains a subset of neurons designated as lot cells, which guide the axons through short-range interactions. It is not clear how these two guidance cues relate to each other and how they share the physiological roles. Here we examined the behavior of mitral cell axons in organotypic culture on ectopic application of Slit and inhibition of endogenous Slit signaling. The results suggested that the short-range guidance cue in the LOT pathway functions independently from Slit. Furthermore, our results showed that removal of the septum and inhibition of Slit signaling did not affect the projection of mitral cell axons. Although the septum and exogenous Slit can repel olfactory bulb axons, our results cast doubts on the physiological relevance of the septum and endogenous Slit in guiding the projection of mitral cell axons.

Key words: development; growth; mitral cells; lateral olfactory tract; Slit; guidance cue

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/2172373-07$05.00/0

This article has been cited by other articles:

				C. Fouquet, T. Di Meglio, L. Ma, T. Kawasaki, H. Long, T. Hirata, M. Tessier-Lavigne, A. Chedotal, and K. T. Nguyen-Ba-Charvet Robo1 and Robo2 Control the Development of the Lateral Olfactory Tract J. Neurosci., March 14, 2007; 27(11): 3037 - 3045. [Abstract] [Full Text] [PDF]

				M. Ward, C. McCann, M. DeWulf, J. Y. Wu, and Y. Rao Distinguishing between Directional Guidance and Motility Regulation in Neuronal Migration J. Neurosci., June 15, 2003; 23(12): 5170 - 5177. [Abstract] [Full Text] [PDF]

				K. T. Nguyen-Ba-Charvet, A. S. Plump, M. Tessier-Lavigne, and A. Chedotal Slit1 and Slit2 Proteins Control the Development of the Lateral Olfactory Tract J. Neurosci., July 1, 2002; 22(13): 5473 - 5480. [Abstract] [Full Text] [PDF]

				K. Patel, J. A. B. Nash, A. Itoh, Z. Liu, V. Sundaresan, and A. Pini Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons Development, December 15, 2001; 128(24): 5031 - 5037. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help