 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, April 15, 2001, 21(8):2889-2896
Growth and Functional Efficacy of Intrastriatal Nigral Transplants Depend on the Extent of Nigrostriatal Degeneration
Deniz Kirik, Christian Winkler, and Anders Björklund Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, 22184, Lund, Sweden
Previous studies have shown that the functional efficacy of intrastriatal transplants of fetal dopamine (DA) neurons in the rat Parkinson model depends on their ability to establish a new functional innervation of the denervated striatum. Here we report that the survival, growth, and function of the grafted DA neurons greatly depend on the severity of the lesion of the host nigrostriatal system. Fiber outgrowth, and to a lesser extent also cell survival, were significantly reduced in animals in which part of the intrinsic DA system was left intact. Moreover, graft-induced functional recovery, as assessed in the stepping, paw-use, and apomorphine rotation tests, was obtained only in severely lesioned animals, i.e., in rats with >70% DA denervation of the host striatum. Functional recovery seen in these animals in which the 6-hydroxydopamine (6-OHDA) lesion was confined to the striatum was more pronounced than that previously obtained in rats with complete lesions of the mesencephalic DA system, indicating that spared portions of the host DA system, particularly those innervating nonstriatal forebrain areas, may be necessary for the grafts to exert their optimal functional effect. These data have implications for the optimal use of fetal nigral transplants in Parkinson patients in different stages of the disease.
Key words: Parkinson's disease; 6-hydroxydopamine; transplantation; sensorimotor behavior; stepping; paw use; tyrosine hydroxylase; stereology
Copyright © 2001 Society for Neuroscience 0270-6474/01/2182889-08$05.00/0
This article has been cited by other articles:
T. Carlsson, M. Carta, A. Munoz, B. Mattsson, C. Winkler, D. Kirik, and A. Bjorklund
Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration
Brain, February 1, 2009; 132(2): 319 - 335.
[Abstract] [Full Text] [PDF]
A. Munoz, Q. Li, F. Gardoni, E. Marcello, C. Qin, T. Carlsson, D. Kirik, M. Di Luca, A. Bjorklund, E. Bezard, et al.
Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
Brain, December 1, 2008; 131(12): 3380 - 3394.
[Abstract] [Full Text] [PDF]
T. Carlsson, M. Carta, C. Winkler, A. Bjorklund, and D. Kirik
Serotonin Neuron Transplants Exacerbate L-DOPA- Induced Dyskinesias in a Rat Model of Parkinson's Disease
J. Neurosci., July 25, 2007; 27(30): 8011 - 8022.
[Abstract] [Full Text] [PDF]
N. Breysse, T. Carlsson, C. Winkler, A. Bjorklund, and D. Kirik
The Functional Impact of the Intrastriatal Dopamine Neuron Grafts in Parkinsonian Rats Is Reduced with Advancing Disease
J. Neurosci., May 30, 2007; 27(22): 5849 - 5856.
[Abstract] [Full Text] [PDF]
P. Piccini, N. Pavese, P. Hagell, J. Reimer, A. Bjorklund, W. H. Oertel, N. P. Quinn, D. J. Brooks, and O. Lindvall
Factors affecting the clinical outcome after neural transplantation in Parkinson's disease
Brain, December 1, 2005; 128(12): 2977 - 2986.
[Abstract] [Full Text] [PDF]
L. Thompson, P. Barraud, E. Andersson, D. Kirik, and A. Bjorklund
Identification of Dopaminergic Neurons of Nigral and Ventral Tegmental Area Subtypes in Grafts of Fetal Ventral Mesencephalon Based on Cell Morphology, Protein Expression, and Efferent Projections
J. Neurosci., July 6, 2005; 25(27): 6467 - 6477.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|