 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, May 1, 2001, 21(9):3063-3072
An NMDA Receptor ER Retention Signal Regulated by Phosphorylation and Alternative Splicing
Derek B. Scott1, 2, Thomas A. Blanpied2, Geoffrey T. Swanson3, Chi Zhang2, and Michael D. Ehlers1, 2 1 Program in Cell and Molecular Biology and 2 Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, and 3 Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037
Formation of mature excitatory synapses requires the assembly and delivery of NMDA receptors to the neuronal plasma membrane. A key step in the trafficking of NMDA receptors to synapses is the exit of newly assembled receptors from the endoplasmic reticulum (ER). Here we report the identification of an RXR-type ER retention/retrieval motif in the C-terminal tail of the NMDA receptor subunit NR1 that regulates receptor surface expression in heterologous cells and in neurons. In addition, we show that PKC phosphorylation and an alternatively spliced consensus type I PDZ-binding domain suppress ER retention. These results demonstrate a novel quality control function for alternatively spliced C-terminal domains of NR1 and implicate both phosphorylation and potential PDZ-mediated interactions in the trafficking of NMDA receptors through early stages of the secretory pathway.
Key words: ER retention; NMDA receptors; NR1 subunit; RXR motif; quality control mechanisms; intracellular trafficking
Copyright © 2001 Society for Neuroscience 0270-6474/01/2193063-10$05.00/0
This article has been cited by other articles:
C. T. Smothers and J. J. Woodward
Expression of Glycine-Activated Diheteromeric NR1/NR3 Receptors in Human Embryonic Kidney 293 Cells Is NR1 Splice Variant-Dependent
J. Pharmacol. Exp. Ther., December 1, 2009; 331(3): 975 - 984.
[Abstract] [Full Text] [PDF]
J.-A. Lee, Z.-Z. Tang, and D. L. Black
An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons
Genes & Dev., October 1, 2009; 23(19): 2284 - 2293.
[Abstract] [Full Text] [PDF]
J. C. Reneau, M. E. Reyland, J. Phillips, C. Kindy, and R. L. Popp
Phorbol 12-Myristate 13-Acetate Potentiation of N-Methyl-D-aspartate-Induced Currents in Primary Cultured Cerebellar Granule Cells Is Mediated by Protein Kinase C{alpha}
J. Pharmacol. Exp. Ther., August 1, 2009; 330(2): 641 - 649.
[Abstract] [Full Text] [PDF]
M. Horak and R. J. Wenthold
Different Roles of C-terminal Cassettes in the Trafficking of Full-length NR1 Subunits to the Cell Surface
J. Biol. Chem., April 10, 2009; 284(15): 9683 - 9691.
[Abstract] [Full Text] [PDF]
M. E. Schober, R. A. McKnight, X. Yu, C. W. Callaway, X. Ke, and R. H. Lane
Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R681 - R692.
[Abstract] [Full Text] [PDF]
S. K. Coleman, T. Moykkynen, A. Jouppila, S. Koskelainen, C. Rivera, E. R Korpi, and K. Keinanen
Agonist Occupancy Is Essential for Forward Trafficking of AMPA Receptors
J. Neurosci., January 14, 2009; 29(2): 303 - 312.
[Abstract] [Full Text] [PDF]
A. V. Kenny, S. L. Cousins, L. Pinho, and F. A. Stephenson
The Integrity of the Glycine Co-agonist Binding Site of N-Methyl-D-aspartate Receptors Is a Functional Quality Control Checkpoint for Cell Surface Delivery
J. Biol. Chem., January 2, 2009; 284(1): 324 - 333.
[Abstract] [Full Text] [PDF]
M. Dunkel, A. Latz, K. Schumacher, T. Muller, D. Becker, and R. Hedrich
Targeting of Vacuolar Membrane Localized Members of the TPK Channel Family
Mol Plant, November 1, 2008; 1(6): 938 - 949.
[Abstract] [Full Text] [PDF]
F. Fumagalli, A. Frasca, G. Racagni, and M. A. Riva
Dynamic Regulation of Glutamatergic Postsynaptic Activity in Rat Prefrontal Cortex by Repeated Administration of Antipsychotic Drugs
Mol. Pharmacol., May 1, 2008; 73(5): 1484 - 1490.
[Abstract] [Full Text] [PDF]
M. Horak, K. Chang, and R. J. Wenthold
Masking of the Endoplasmic Reticulum Retention Signals during Assembly of the NMDA Receptor
J. Neurosci., March 26, 2008; 28(13): 3500 - 3509.
[Abstract] [Full Text] [PDF]
C. Villmann and C.-M. Becker
On the Hypes and Falls in Neuroprotection: Targeting the NMDA Receptor
Neuroscientist, December 1, 2007; 13(6): 594 - 615.
[Abstract] [PDF]
Q. Ouyang, M. Goeritz, and R. M. Harris-Warrick
Panulirus interruptus Ih-Channel Gene PIIH: Modification of Channel Properties by Alternative Splicing and Role in Rhythmic Activity
J Neurophysiol, June 1, 2007; 97(6): 3880 - 3892.
[Abstract] [Full Text] [PDF]
I. E. Michailidis, T. D. Helton, V. I. Petrou, T. Mirshahi, M. D. Ehlers, and D. E. Logothetis
Phosphatidylinositol-4,5-Bisphosphate Regulates NMDA Receptor Activity through {alpha}-Actinin
J. Neurosci., May 16, 2007; 27(20): 5523 - 5532.
[Abstract] [Full Text] [PDF]
M. M. Y. Fan, H. B. Fernandes, L. Y. J. Zhang, M. R. Hayden, and L. A. Raymond
Altered NMDA Receptor Trafficking in a Yeast Artificial Chromosome Transgenic Mouse Model of Huntington's Disease
J. Neurosci., April 4, 2007; 27(14): 3768 - 3779.
[Abstract] [Full Text] [PDF]
W. Yang, C. Zheng, Q. Song, X. Yang, S. Qiu, C. Liu, Z. Chen, S. Duan, and J. Luo
A Three Amino Acid Tail Following the TM4 Region of the N-Methyl-D-aspartate Receptor (NR) 2 Subunits Is Sufficient to Overcome Endoplasmic Reticulum Retention of NR1-1a Subunit
J. Biol. Chem., March 23, 2007; 282(12): 9269 - 9278.
[Abstract] [Full Text] [PDF]
J. J. Yi and M. D. Ehlers
Emerging Roles for Ubiquitin and Protein Degradation in Neuronal Function
Pharmacol. Rev., March 1, 2007; 59(1): 14 - 39.
[Abstract] [Full Text] [PDF]
D. Bao, Z. Pang, M. A. Morgan, J. Parris, Y. Rong, L. Li, and J. I. Morgan
Cbln1 Is Essential for Interaction-Dependent Secretion of Cbln3
Mol. Cell. Biol., December 15, 2006; 26(24): 9327 - 9337.
[Abstract] [Full Text] [PDF]
S. Kumar, B. M. Lane, and A. L. Morrow
Differential Effects of Systemic Ethanol Administration on Protein Kinase C{epsilon}, {gamma}, and beta Isoform Expression, Membrane Translocation, and Target Phosphorylation: Reversal by Chronic Ethanol Exposure
J. Pharmacol. Exp. Ther., December 1, 2006; 319(3): 1366 - 1375.
[Abstract] [Full Text] [PDF]
H. Hallaq, Z. Yang, P. C. Viswanathan, K. Fukuda, W. Shen, D. W. Wang, K. S. Wells, J. Zhou, J. Yi, and K. T. Murray
Quantitation of protein kinase A-mediated trafficking of cardiac sodium channels in living cells
Cardiovasc Res, November 1, 2006; 72(2): 250 - 261.
[Abstract] [Full Text] [PDF]
Y. Nasu-Nishimura, D. Hurtado, S. Braud, T. T.-T. Tang, J. T. R. Isaac, and K. W. Roche
Identification of an Endoplasmic Reticulum-Retention Motif in an Intracellular Loop of the Kainate Receptor Subunit KA2
J. Neurosci., June 28, 2006; 26(26): 7014 - 7021.
[Abstract] [Full Text] [PDF]
B.-S. Chen, S. Braud, J. D. Badger II, J. T. R. Isaac, and K. W. Roche
Regulation of NR1/NR2C N-Methyl-D-aspartate (NMDA) Receptors by Phosphorylation
J. Biol. Chem., June 16, 2006; 281(24): 16583 - 16590.
[Abstract] [Full Text] [PDF]
P. Vivithanaporn, S. Yan, and G. T. Swanson
Intracellular Trafficking of KA2 Kainate Receptors Mediated by Interactions with Coatomer Protein Complex I (COPI) and 14-3-3 Chaperone Systems
J. Biol. Chem., June 2, 2006; 281(22): 15475 - 15484.
[Abstract] [Full Text] [PDF]
M. W. Fleck
Glutamate Receptors and Endoplasmic Reticulum Quality Control: Looking beneath the Surface
Neuroscientist, June 1, 2006; 12(3): 232 - 244.
[Abstract] [PDF]
J. Bradley, S. R. Carter, V. R. Rao, J. Wang, and S. Finkbeiner
Splice Variants of the NR1 Subunit Differentially Induce NMDA Receptor-Dependent Gene Expression
J. Neurosci., January 25, 2006; 26(4): 1065 - 1076.
[Abstract] [Full Text] [PDF]
H. Fukuda, N. Nakamura, and S. Hirose
MARCH-III Is a Novel Component of Endosomes with Properties Similar to Those of MARCH-II
J. Biochem., January 1, 2006; 139(1): 137 - 145.
[Abstract] [Full Text] [PDF]
D. Yoo, L. Fang, A. Mason, B.-Y. Kim, and P. A. Welling
A Phosphorylation-dependent Export Structure in ROMK (Kir 1.1) Channel Overrides an Endoplasmic Reticulum Localization Signal
J. Biol. Chem., October 21, 2005; 280(42): 35281 - 35289.
[Abstract] [Full Text] [PDF]
H. Khalil, A. Brunet, and J. Thibodeau
A three-amino-acid-long HLA-DR{beta} cytoplasmic tail is sufficient to overcome ER retention of invariant-chain p35
J. Cell Sci., October 15, 2005; 118(20): 4679 - 4687.
[Abstract] [Full Text] [PDF]
K. J. Palmer, J. E. Konkel, and D. J. Stephens
PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport
J. Cell Sci., September 1, 2005; 118(17): 3839 - 3847.
[Abstract] [Full Text] [PDF]
E. Y. Yuen, Q. Jiang, J. Feng, and Z. Yan
Microtubule Regulation of N-Methyl-D-aspartate Receptor Channels in Neurons
J. Biol. Chem., August 19, 2005; 280(33): 29420 - 29427.
[Abstract] [Full Text] [PDF]
A. D. O'Connell, Q. Leng, K. Dong, G. G. MacGregor, G. Giebisch, and S. C. Hebert
Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK)
PNAS, July 12, 2005; 102(28): 9954 - 9959.
[Abstract] [Full Text] [PDF]
M. Gassmann, C. Haller, Y. Stoll, S. A. Aziz, B. Biermann, J. Mosbacher, K. Kaupmann, and B. Bettler
The RXR-Type Endoplasmic Reticulum-Retention/Retrieval Signal of GABAB1 Requires Distant Spacing from the Membrane to Function
Mol. Pharmacol., July 1, 2005; 68(1): 137 - 144.
[Abstract] [Full Text] [PDF]
F. Jaskolski, E. Normand, C. Mulle, and F. Coussen
Differential Trafficking of GluR7 Kainate Receptor Subunit Splice Variants
J. Biol. Chem., June 17, 2005; 280(24): 22968 - 22976.
[Abstract] [Full Text] [PDF]
C.-C. Lee, C.-C. Huang, M.-Y. Wu, and K.-S. Hsu
Insulin Stimulates Postsynaptic Density-95 Protein Translation via the Phosphoinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Signaling Pathway
J. Biol. Chem., May 6, 2005; 280(18): 18543 - 18550.
[Abstract] [Full Text] [PDF]
R. T. Terry-Lorenzo, D. W. Roadcap, T. Otsuka, T. A. Blanpied, P. L. Zamorano, C. C. Garner, S. Shenolikar, and M. D. Ehlers
Neurabin/Protein Phosphatase-1 Complex Regulates Dendritic Spine Morphogenesis and Maturation
Mol. Biol. Cell, May 1, 2005; 16(5): 2349 - 2362.
[Abstract] [Full Text] [PDF]
K. Nakayama, K. Kiyosue, and T. Taguchi
Diminished Neuronal Activity Increases Neuron-Neuron Connectivity Underlying Silent Synapse Formation and the Rapid Conversion of Silent to Functional Synapses
J. Neurosci., April 20, 2005; 25(16): 4040 - 4051.
[Abstract] [Full Text] [PDF]
S. J. Mah, E. Cornell, N. A. Mitchell, and M. W. Fleck
Glutamate Receptor Trafficking: Endoplasmic Reticulum Quality Control Involves Ligand Binding and Receptor Function
J. Neurosci., March 2, 2005; 25(9): 2215 - 2225.
[Abstract] [Full Text] [PDF]
L. Valluru, J. Xu, Y. Zhu, S. Yan, A. Contractor, and G. T. Swanson
Ligand Binding Is a Critical Requirement for Plasma Membrane Expression of Heteromeric Kainate Receptors
J. Biol. Chem., February 18, 2005; 280(7): 6085 - 6093.
[Abstract] [Full Text] [PDF]
V. Haufe, J.M. Cordeiro, T. Zimmer, Y.S. Wu, S. Schiccitano, K. Benndorf, and R. Dumaine
Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventricles
Cardiovasc Res, January 1, 2005; 65(1): 117 - 127.
[Abstract] [Full Text] [PDF]
Y. Lin, V. A. Skeberdis, A. Francesconi, M. V. L. Bennett, and R. S. Zukin
Postsynaptic Density Protein-95 Regulates NMDA Channel Gating and Surface Expression
J. Neurosci., November 10, 2004; 24(45): 10138 - 10148.
[Abstract] [Full Text] [PDF]
H. J. Chung, Y. H. Huang, L.-F. Lau, and R. L. Huganir
Regulation of the NMDA Receptor Complex and Trafficking by Activity-Dependent Phosphorylation of the NR2B Subunit PDZ Ligand
J. Neurosci., November 10, 2004; 24(45): 10248 - 10259.
[Abstract] [Full Text] [PDF]
J. Shim, T. Umemura, E. Nothstein, and C. Rongo
The Unfolded Protein Response Regulates Glutamate Receptor Export from the Endoplasmic Reticulum
Mol. Biol. Cell, November 1, 2004; 15(11): 4818 - 4828.
[Abstract] [Full Text] [PDF]
S. G. Cull-Candy and D. N. Leszkiewicz
Role of Distinct NMDA Receptor Subtypes at Central Synapses
Sci. Signal., October 19, 2004; 2004(255): re16 - re16.
[Abstract] [Full Text] [PDF]
P. Washbourne, X.-B. Liu, E. G. Jones, and A. K. McAllister
Cycling of NMDA Receptors during Trafficking in Neurons before Synapse Formation
J. Neurosci., September 22, 2004; 24(38): 8253 - 8264.
[Abstract] [Full Text] [PDF]
M. Abe, M. Fukaya, T. Yagi, M. Mishina, M. Watanabe, and K. Sakimura
NMDA Receptor GluR{epsilon}/NR2 Subunits Are Essential for Postsynaptic Localization and Protein Stability of GluR{zeta}1/NR1 Subunit
J. Neurosci., August 18, 2004; 24(33): 7292 - 7304.
[Abstract] [Full Text] [PDF]
D. B. Scott, I. Michailidis, Y. Mu, D. Logothetis, and M. D. Ehlers
Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals
J. Neurosci., August 11, 2004; 24(32): 7096 - 7109.
[Abstract] [Full Text] [PDF]
D. Ron
Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol
Neuroscientist, August 1, 2004; 10(4): 325 - 336.
[Abstract] [PDF]
G. Lavezzari, J. McCallum, C. M. Dewey, and K. W. Roche
Subunit-Specific Regulation of NMDA Receptor Endocytosis
J. Neurosci., July 14, 2004; 24(28): 6383 - 6391.
[Abstract] [Full Text] [PDF]
L. M. Hawkins, K. Prybylowski, K. Chang, C. Moussan, F. A. Stephenson, and R. J. Wenthold
Export from the Endoplasmic Reticulum of Assembled N-Methyl-D-aspartic Acid Receptors Is Controlled by a Motif in the C Terminus of the NR2 Subunit
J. Biol. Chem., July 9, 2004; 279(28): 28903 - 28910.
[Abstract] [Full Text] [PDF]
M. M. Zarei, M. Eghbali, A. Alioua, M. Song, H.-G. Knaus, E. Stefani, and L. Toro
An endoplasmic reticulum trafficking signal prevents surface expression of a voltage- and Ca2+-activated K+ channel splice variant
PNAS, July 6, 2004; 101(27): 10072 - 10077.
[Abstract] [Full Text] [PDF]
S. G. Birnbaum, A. W. Varga, L.-L. Yuan, A. E. Anderson, J. D. Sweatt, and L. A. Schrader
Structure and Function of Kv4-Family Transient Potassium Channels
Physiol Rev, July 1, 2004; 84(3): 803 - 833.
[Abstract] [Full Text] [PDF]
B. Bettler, K. Kaupmann, J. Mosbacher, and M. Gassmann
Molecular Structure and Physiological Functions of GABAB Receptors
Physiol Rev, July 1, 2004; 84(3): 835 - 867.
[Abstract] [Full Text] [PDF]
C. Heine, B. Koch, S. Storch, A. Kohlschutter, D. N. Palmer, and T. Braulke
Defective Endoplasmic Reticulum-resident Membrane Protein CLN6 Affects Lysosomal Degradation of Endocytosed Arylsulfatase A
J. Biol. Chem., May 21, 2004; 279(21): 22347 - 22352.
[Abstract] [Full Text] [PDF]
K. Prybylowski and R. J. Wenthold
N-Methyl-D-aspartate Receptors: Subunit Assembly and Trafficking to the Synapse
J. Biol. Chem., March 12, 2004; 279(11): 9673 - 9676.
[Full Text] [PDF]
F. Jaskolski, F. Coussen, N. Nagarajan, E. Normand, C. Rosenmund, and C. Mulle
Subunit Composition and Alternative Splicing Regulate Membrane Delivery of Kainate Receptors
J. Neurosci., March 10, 2004; 24(10): 2506 - 2515.
[Abstract] [Full Text] [PDF]
D. Yoo, T. P. Flagg, O. Olsen, V. Raghuram, J. K. Foskett, and P. A. Welling
Assembly and Trafficking of a Multiprotein ROMK (Kir 1.1) Channel Complex by PDZ Interactions
J. Biol. Chem., February 20, 2004; 279(8): 6863 - 6873.
[Abstract] [Full Text] [PDF]
S. Yan, J. M. Sanders, J. Xu, Y. Zhu, A. Contractor, and G. T. Swanson
A C-Terminal Determinant of GluR6 Kainate Receptor Trafficking
J. Neurosci., January 21, 2004; 24(3): 679 - 691.
[Abstract] [Full Text] [PDF]
Z. Ren, N. J. Riley, L. A. Needleman, J. M. Sanders, G. T. Swanson, and J. Marshall
Cell Surface Expression of GluR5 Kainate Receptors Is Regulated by an Endoplasmic Reticulum Retention Signal
J. Biol. Chem., December 26, 2003; 278(52): 52700 - 52709.
[Abstract] [Full Text] [PDF]
M. A. Davare and J. W. Hell
Increased phosphorylation of the neuronal L-type Ca2+ channel Cav1.2 during aging
PNAS, December 23, 2003; 100(26): 16018 - 16023.
[Abstract] [Full Text] [PDF]
R. Nashmi, M. E. Dickinson, S. McKinney, M. Jareb, C. Labarca, S. E. Fraser, and H. A. Lester
Assembly of {alpha}4{beta}2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons
J. Neurosci., December 17, 2003; 23(37): 11554 - 11567.
[Abstract] [Full Text] [PDF]
K. Matsuda, M. Fletcher, Y. Kamiya, and M. Yuzaki
Specific Assembly with the NMDA Receptor 3B Subunit Controls Surface Expression and Calcium Permeability of NMDA Receptors
J. Neurosci., November 5, 2003; 23(31): 10064 - 10073.
[Abstract] [Full Text] [PDF]
A. Akhavan, R. Atanasiu, and A. Shrier
Identification of a COOH-terminal Segment Involved in Maturation and Stability of Human Ether-a-go-go-related Gene Potassium Channels
J. Biol. Chem., October 10, 2003; 278(41): 40105 - 40112.
[Abstract] [Full Text] [PDF]
H. Khalil, A. Brunet, I. Saba, R. Terra, R. P. Sekaly, and J. Thibodeau
The MHC class II {beta} chain cytoplasmic tail overcomes the invariant chain p35-encoded endoplasmic reticulum retention signal
Int. Immunol., October 1, 2003; 15(10): 1249 - 1263.
[Abstract] [Full Text] [PDF]
S. Kjaer and C. F. Ibanez
Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET
Hum. Mol. Genet., September 1, 2003; 12(17): 2133 - 2144.
[Abstract] [Full Text] [PDF]
Z. Ren, N. J. Riley, E. P. Garcia, J. M. Sanders, G. T. Swanson, and J. Marshall
Multiple Trafficking Signals Regulate Kainate Receptor KA2 Subunit Surface Expression
J. Neurosci., July 23, 2003; 23(16): 6608 - 6616.
[Abstract] [Full Text] [PDF]
G. W. Boyd, A. I. Doward, E. F. Kirkness, N. S. Millar, and C. N. Connolly
Cell Surface Expression of 5-Hydroxytryptamine Type 3 Receptors Is Controlled by an Endoplasmic Reticulum Retention Signal
J. Biol. Chem., July 18, 2003; 278(30): 27681 - 27687.
[Abstract] [Full Text] [PDF]
S. M. Clinton, V. Haroutunian, K. L. Davis, and J. H. Meador-Woodruff
Altered Transcript Expression of NMDA Receptor-Associated Postsynaptic Proteins in the Thalamus of Subjects With Schizophrenia
Am J Psychiatry, June 1, 2003; 160(6): 1100 - 1109.
[Abstract] [Full Text] [PDF]
C. Fiorentini, F. Gardoni, P. Spano, M. Di Luca, and C. Missale
Regulation of Dopamine D1 Receptor Trafficking and Desensitization by Oligomerization with Glutamate N-Methyl-D-aspartate Receptors
J. Biol. Chem., May 23, 2003; 278(22): 20196 - 20202.
[Abstract] [Full Text] [PDF]
S. Schorge and D. Colquhoun
Studies of NMDA Receptor Function and Stoichiometry with Truncated and Tandem Subunits
J. Neurosci., February 15, 2003; 23(4): 1151 - 1158.
[Abstract] [Full Text] [PDF]
J. J. Zhu
Mechanisms of Synaptic Plasticity: From Membrane to Intracellular AMPAR Trafficking
Mol. Interv., February 1, 2003; 3(1): 15 - 18.
[Abstract] [Full Text] [PDF]
H. Xia, M. von Zastrow, and R. C. Malenka
A Novel Anterograde Trafficking Signal Present in the N-terminal Extracellular Domain of Ionotropic Glutamate Receptors
J. Biol. Chem., November 27, 2002; 277(49): 47765 - 47769.
[Abstract] [Full Text] [PDF]
M. Sheng and M. J. Kim
Postsynaptic Signaling and Plasticity Mechanisms
Science, October 25, 2002; 298(5594): 776 - 780.
[Abstract] [Full Text] [PDF]
B. W. M. van Balkom, P. J. M. Savelkoul, D. Markovich, E. Hofman, S. Nielsen, P. van der Sluijs, and P. M. T. Deen
The Role of Putative Phosphorylation Sites in the Targeting and Shuttling of the Aquaporin-2 Water Channel
J. Biol. Chem., October 25, 2002; 277(44): 41473 - 41479.
[Abstract] [Full Text] [PDF]
K. Prybylowski, Z. Fu, G. Losi, L. M. Hawkins, J. Luo, K. Chang, R. J. Wenthold, and S. Vicini
Relationship between Availability of NMDA Receptor Subunits and Their Expression at the Synapse
J. Neurosci., October 15, 2002; 22(20): 8902 - 8910.
[Abstract] [Full Text] [PDF]
B. U. Failer, N. Braun, and H. Zimmermann
Cloning, Expression, and Functional Characterization of a Ca2+-dependent Endoplasmic Reticulum Nucleoside Diphosphatase
J. Biol. Chem., September 27, 2002; 277(40): 36978 - 36986.
[Abstract] [Full Text] [PDF]
J. Zhou, H.-G. Shin, J. Yi, W. Shen, C. P. Williams, and K. T. Murray
Phosphorylation and Putative ER Retention Signals Are Required for Protein Kinase A-Mediated Potentiation of Cardiac Sodium Current
Circ. Res., September 20, 2002; 91(6): 540 - 546.
[Abstract] [Full Text] [PDF]
R. P. Guttmann, S. Sokol, D. L. Baker, K. L. Simpkins, Y. Dong, and D. R. Lynch
Proteolysis of the N-Methyl-D-Aspartate Receptor by Calpain in Situ
J. Pharmacol. Exp. Ther., September 1, 2002; 302(3): 1023 - 1030.
[Abstract] [Full Text] [PDF]
I. A. Lim, D. D. Hall, and J. W. Hell
Selectivity and Promiscuity of the First and Second PDZ Domains of PSD-95 and Synapse-associated Protein 102
J. Biol. Chem., June 7, 2002; 277(24): 21697 - 21711.
[Abstract] [Full Text] [PDF]
D. K. Fong, A. Rao, F. T. Crump, and A. M. Craig
Rapid Synaptic Remodeling by Protein Kinase C: Reciprocal Translocation of NMDA Receptors and Calcium/Calmodulin-Dependent Kinase II
J. Neurosci., March 15, 2002; 22(6): 2153 - 2164.
[Abstract] [Full Text] [PDF]
A. W. Dunah and D. G. Standaert
Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane
J. Neurosci., August 1, 2001; 21(15): 5546 - 5558.
[Abstract] [Full Text] [PDF]
K. D. Holmes, P. A. Mattar, D. R. Marsh, L. C. Weaver, and G. A. Dekaban
The N-Methyl-D-aspartate Receptor Splice Variant NR1-4 C-terminal Domain. DELETION ANALYSIS AND ROLE IN SUBCELLULAR DISTRIBUTION
J. Biol. Chem., January 4, 2002; 277(2): 1457 - 1468.
[Abstract] [Full Text] [PDF]
M. Nishi, H. Hinds, H.-P. Lu, M. Kawata, and Y. Hayashi
Motoneuron-Specific Expression of NR3B, a Novel NMDA-Type Glutamate Receptor Subunit That Works in a Dominant-Negative Manner
J. Neurosci., December 1, 2001; 21(23): RC185 - RC185.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|