QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (84) Citing Articles via Google Scholar Google Scholar Articles by Tanemura, K. Articles by Takashima, A. Search for Related Content PubMed PubMed Citation Articles by Tanemura, K. Articles by Takashima, A.

 Previous Article  |  Next Article 

The Journal of Neuroscience, January 1, 2002, 22(1):133-141

Neurodegeneration with Tau Accumulation in a Transgenic Mouse Expressing V337M Human Tau

Kentaro Tanemura¹, Miyuki Murayama¹, Takumi Akagi², Tsutomu Hashikawa², Takashi Tominaga³, Michinori Ichikawa³, Haruyasu Yamaguchi⁴, and Akihiko Takashima¹

¹ Laboratory for Alzheimer's Disease, ² Neural Architecture, and ³ Brain Operative Device, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan, and ⁴ Gunma University School of Health Sciences, Gunma 371-8511, Japan

Formation of neurofibrillary tangles (NFTs) is a common neuropathological feature found in several neurodegenerative diseases, including Alzheimer's disease. We have developed a transgenic (Tg) mouse expressing mutant human tau (V337M), derived from frontotemporal dementia parkinsonism-17. V337M Tg mice revealed tau aggregations in the hippocampus, which fulfills the histological criteria for NFTs in human neurodegenerative diseases. Concurrent with the accumulation of RNA and phosphorylated tau, neurons exhibited morphological characteristics of degenerating neurons, which include a loss of microtubules, accumulation of ribosomes, plasma and nuclear membrane ruffling, and swelling of the Golgi network. Thus, mutant tau induces neuronal degeneration associated with the accumulation of RNA and phosphorylated tau. The functional consequences of this neuronal degeneration was evidenced by the reduction of hippocampal neural activity and behavioral abnormality in Tg mice.

Key words: neurodegeneration; phosphorylated tau; RNA; NFT; Tg mouse; FTDP-17

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/221133-09$05.00/0

This article has been cited by other articles:

				C. Dickey, C. Kraft, U. Jinwal, J. Koren, A. Johnson, L. Anderson, L. Lebson, D. Lee, D. Dickson, R. de Silva, et al. Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy Am. J. Pathol., January 1, 2009; 174(1): 228 - 238. [Abstract] [Full Text] [PDF]

				S. Vergarajauregui, P. S. Connelly, M. P. Daniels, and R. Puertollano Autophagic dysfunction in mucolipidosis type IV patients Hum. Mol. Genet., September 1, 2008; 17(17): 2723 - 2737. [Abstract] [Full Text] [PDF]

				M. W. Wooten, T. Geetha, J. R. Babu, M. L. Seibenhener, J. Peng, N. Cox, M.-T. Diaz-Meco, and J. Moscat Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins J. Biol. Chem., March 14, 2008; 283(11): 6783 - 6789. [Abstract] [Full Text] [PDF]

				K. Leroy, A. Bretteville, K. Schindowski, E. Gilissen, M. Authelet, R. De Decker, Z. Yilmaz, L. Buee, and J.-P. Brion Early Axonopathy Preceding Neurofibrillary Tangles in Mutant Tau Transgenic Mice Am. J. Pathol., September 1, 2007; 171(3): 976 - 992. [Abstract] [Full Text] [PDF]

				S. L. Lambourne, T. Humby, A. R. Isles, P. C. Emson, M. G. Spillantini, and L. S. Wilkinson Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age Hum. Mol. Genet., July 15, 2007; 16(14): 1708 - 1719. [Abstract] [Full Text] [PDF]

				O. Blard, S. Feuillette, J. Bou, B. Chaumette, T. Frebourg, D. Campion, and M. Lecourtois Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila Hum. Mol. Genet., March 1, 2007; 16(5): 555 - 566. [Abstract] [Full Text] [PDF]

				T. Murakami, E. Paitel, T. Kawarabayashi, M. Ikeda, M. A. Chishti, C. Janus, E. Matsubara, A. Sasaki, T. Kawarai, A. L. Phinney, et al. Cortical Neuronal and Glial Pathology in TgTauP301L Transgenic Mice: Neuronal Degeneration, Memory Disturbance, and Phenotypic Variation Am. J. Pathol., October 1, 2006; 169(4): 1365 - 1375. [Abstract] [Full Text] [PDF]

				K. Schindowski, A. Bretteville, K. Leroy, S. Begard, J.-P. Brion, M. Hamdane, and L. Buee Alzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits Am. J. Pathol., August 1, 2006; 169(2): 599 - 616. [Abstract] [Full Text] [PDF]

				K. Boekhoorn, D. Terwel, B. Biemans, P. Borghgraef, O. Wiegert, G. J. A. Ramakers, K. de Vos, H. Krugers, T. Tomiyama, H. Mori, et al. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. J. Neurosci., March 29, 2006; 26(13): 3514 - 3523. [Abstract] [Full Text] [PDF]

				P. Delobel, I. Lavenir, B. Ghetti, M. Holzer, and M. Goedert Cell-Cycle Markers in a Transgenic Mouse Model of Human Tauopathy: Increased Levels of Cyclin-Dependent Kinase Inhibitors p21Cip1 and p27Kip1 Am. J. Pathol., March 1, 2006; 168(3): 878 - 887. [Abstract] [Full Text] [PDF]

				K. Tanemura, D.-H. Chui, T. Fukuda, M. Murayama, J.-M. Park, T. Akagi, Y. Tatebayashi, T. Miyasaka, T. Kimura, T. Hashikawa, et al. Formation of Tau Inclusions in Knock-in Mice with Familial Alzheimer Disease (FAD) Mutation of Presenilin 1 (PS1) J. Biol. Chem., February 24, 2006; 281(8): 5037 - 5041. [Abstract] [Full Text] [PDF]

				G. Amadoro, M. T. Ciotti, M. Costanzi, V. Cestari, P. Calissano, and N. Canu From the Cover: NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation PNAS, February 21, 2006; 103(8): 2892 - 2897. [Abstract] [Full Text] [PDF]

				M. Higuchi, B. Zhang, M. S. Forman, Y. Yoshiyama, J. Q. Trojanowski, and V. M.-Y. Lee Axonal Degeneration Induced by Targeted Expression of Mutant Human Tau in Oligodendrocytes of Transgenic Mice That Model Glial Tauopathies J. Neurosci., October 12, 2005; 25(41): 9434 - 9443. [Abstract] [Full Text] [PDF]

				D. Liazoghli, S. Perreault, K. D. Micheva, M. Desjardins, and N. Leclerc Fragmentation of the Golgi Apparatus Induced by the Overexpression of Wild-Type and Mutant Human Tau Forms in Neurons Am. J. Pathol., May 1, 2005; 166(5): 1499 - 1514. [Abstract] [Full Text] [PDF]

				M. Ikeda, M. Shoji, T. Kawarai, T. Kawarabayashi, E. Matsubara, T. Murakami, A. Sasaki, Y. Tomidokoro, Y. Ikarashi, H. Kuribara, et al. Accumulation of Filamentous Tau in the Cerebral Cortex of Human Tau R406W Transgenic Mice Am. J. Pathol., February 1, 2005; 166(2): 521 - 531. [Abstract] [Full Text] [PDF]

				A. Bellucci, A. J. Westwood, E. Ingram, F. Casamenti, M. Goedert, and M. G. Spillantini Induction of Inflammatory Mediators and Microglial Activation in Mice Transgenic for Mutant Human P301S Tau Protein Am. J. Pathol., November 1, 2004; 165(5): 1643 - 1652. [Abstract] [Full Text] [PDF]

				A. d. C. Alonso, A. Mederlyova, M. Novak, I. Grundke-Iqbal, and K. Iqbal Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations J. Biol. Chem., August 13, 2004; 279(33): 34873 - 34881. [Abstract] [Full Text] [PDF]

				A. L. M. Ferri, M. Cavallaro, D. Braida, A. Di Cristofano, A. Canta, A. Vezzani, S. Ottolenghi, P. P. Pandolfi, M. Sala, S. DeBiasi, et al. Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain Development, August 1, 2004; 131(15): 3805 - 3819. [Abstract] [Full Text] [PDF]

				B. Zhang, M. Higuchi, Y. Yoshiyama, T. Ishihara, M. S. Forman, D. Martinez, S. Joyce, J. Q. Trojanowski, and V. M.-Y. Lee Retarded Axonal Transport of R406W Mutant Tau in Transgenic Mice with a Neurodegenerative Tauopathy J. Neurosci., May 12, 2004; 24(19): 4657 - 4667. [Abstract] [Full Text] [PDF]

				J. AVILA, J. J. LUCAS, M. PEREZ, and F. HERNANDEZ Role of Tau Protein in Both Physiological and Pathological Conditions Physiol Rev, April 1, 2004; 84(2): 361 - 384. [Abstract] [Full Text] [PDF]

				Y. Yoshiyama, B. Zhang, J. Bruce, J. Q. Trojanowski, and V. M.-Y. Lee Reduction of Detyrosinated Microtubules and Golgi Fragmentation Are Linked to Tau-Induced Degeneration in Astrocytes J. Neurosci., November 19, 2003; 23(33): 10662 - 10671. [Abstract] [Full Text] [PDF]

				M. Goedert Neurodegenerative tauopathy in the worm PNAS, August 19, 2003; 100(17): 9653 - 9655. [Full Text] [PDF]

				V. M. Miller, H. Xia, G. L. Marrs, C. M. Gouvion, G. Lee, B. L. Davidson, and H. L. Paulson Allele-specific silencing of dominant disease genes PNAS, June 10, 2003; 100(12): 7195 - 7200. [Abstract] [Full Text] [PDF]

				F. Dou, W. J. Netzer, K. Tanemura, F. Li, F. U. Hartl, A. Takashima, G. K. Gouras, P. Greengard, and H. Xu Chaperones increase association of tau protein with microtubules PNAS, January 21, 2003; 100(2): 721 - 726. [Abstract] [Full Text] [PDF]

				B. Allen, E. Ingram, M. Takao, M. J. Smith, R. Jakes, K. Virdee, H. Yoshida, M. Holzer, M. Craxton, P. C. Emson, et al. Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein J. Neurosci., November 1, 2002; 22(21): 9340 - 9351. [Abstract] [Full Text] [PDF]

				Y. Tatebayashi, T. Miyasaka, D.-H. Chui, T. Akagi, K.-i. Mishima, K. Iwasaki, M. Fujiwara, K. Tanemura, M. Murayama, K. Ishiguro, et al. Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau PNAS, October 15, 2002; 99(21): 13896 - 13901. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help