QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (17) Citing Articles via Google Scholar Google Scholar Articles by Chevaleyre, V. Articles by Desarménien, M. G. Search for Related Content PubMed PubMed Citation Articles by Chevaleyre, V. Articles by Desarménien, M. G.

 Previous Article  |  Next Article 

The Journal of Neuroscience, January 1, 2002, 22(1):265-273

Interplay between Presynaptic and Postsynaptic Activities Is Required for Dendritic Plasticity and Synaptogenesis in the Supraoptic Nucleus

Vivien Chevaleyre, Françoise C. Moos, and Michel G. Desarménien

Centre National de la Recherche Scientifique Unité Mixte de Recherche 5101, Biologie des Neurones Endocrines, 34094 Montpellier Cedex 5, France

Developing oxytocin and vasopressin (OT/AVP) supraoptic nucleus (SON) neurons positively autocontrol their electrical activity via dendritic release of their respective peptide. The effects of this autocontrol are maximum during the second postnatal week (PW2), when the dendritic arbor transiently increases and glutamatergic postsynaptic potentials appear. Here, we studied the role and interaction of dendritic OT/AVP release and glutamate release in dendritic plasticity and synaptogenesis in SON. In vivo treatment with the peptides antagonists or with an NMDA antagonist suppressed the transient increase in dendritic arbor of SON neurons at the beginning of PW2. Incubation of acute slices with these compounds decreased the dendritic arbor on a short time scale (3-8 hr) in slices of postnatal day 7 (P7) to P9 rats. Conversely, application of OT/AVP or NMDA increased dendritic branches in slices of P3-P6 rats. Their effects were inhibited by blockade of electrical activity, voltage-gated Ca²⁺ channels, or intracellular Ca²⁺ mobilization. They were also interdependent because both OT/AVP and NMDA (but not AMPA) receptor activation were required for increasing the dendritic arbor. Part of this interdependence probably results from a retrograde action of the peptides facilitating glutamate release. Finally, blocking OT/AVP receptors by in vivo treatment with the peptides antagonists during development decreased spontaneous glutamatergic synaptic activity recorded in young adults. These results show that an interplay between postsynaptic dendritic peptide release and presynaptic glutamate release is involved in the transient increase in dendritic arbor of SON neurons and indicate that OT/AVP are required for normal synaptogenesis of glutamatergic inputs in SON.

Key words: oxytocin; vasopressin; glutamate; NMDA receptor; development; electrical activity; retrograde messenger

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/221265-09$05.00/0

This article has been cited by other articles:

				A. Blume, L. Torner, Y. Liu, S. Subburaju, G. Aguilera, and I. D. Neumann Prolactin Activates Mitogen-Activated Protein Kinase Signaling and Corticotropin Releasing Hormone Transcription in Rat Hypothalamic Neurons Endocrinology, April 1, 2009; 150(4): 1841 - 1849. [Abstract] [Full Text] [PDF]

				A. Pena, B. Murat, M. Trueba, M. A. Ventura, G. Bertrand, L. L. Cheng, S. Stoev, H. H. Szeto, N. Wo, G. Brossard, et al. Pharmacological and Physiological Characterization of d[Leu4, Lys8]Vasopressin, the First V1b-Selective Agonist for Rat Vasopressin/Oxytocin Receptors Endocrinology, September 1, 2007; 148(9): 4136 - 4146. [Abstract] [Full Text] [PDF]

				S. H. R. Oliet, D. V. Baimoukhametova, R. Piet, and J. S. Bains Retrograde Regulation of GABA Transmission by the Tonic Release of Oxytocin and Endocannabinoids Governs Postsynaptic Firing J. Neurosci., February 7, 2007; 27(6): 1325 - 1333. [Abstract] [Full Text] [PDF]

				W. E. Armstrong and G. I. Hatton The puzzle of pulsatile oxytocin secretion during lactation: some new pieces Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R26 - R28. [Full Text] [PDF]

				T. J. E. Stachniak and C. W. Bourque Visually guided whole cell patch clamp of mouse supraoptic nucleus neurons in cultured and acute conditions Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R68 - R76. [Abstract] [Full Text] [PDF]

				L. Vutskits, E. Gascon, E. Tassonyi, and J. Z. Kiss Effect of Ketamine on Dendritic Arbor Development and Survival of Immature GABAergic Neurons In Vitro Toxicol. Sci., June 1, 2006; 91(2): 540 - 549. [Abstract] [Full Text] [PDF]

				P. J Whelan Developmental aspects of spinal locomotor function: insights from using the in vitro mouse spinal cord preparation J. Physiol., December 15, 2003; 553(3): 695 - 706. [Abstract] [Full Text] [PDF]

				S. A. Pearson, A. Mouihate, Q. J. Pittman, and P. J. Whelan Peptidergic Activation of Locomotor Pattern Generators in the Neonatal Spinal Cord J. Neurosci., November 5, 2003; 23(31): 10154 - 10163. [Abstract] [Full Text] [PDF]

				H. Widmer, M. Ludwig, F. Bancel, G. Leng, and G. Dayanithi Neurosteroid regulation of oxytocin and vasopressin release from the rat supraoptic nucleus J. Physiol., April 1, 2003; 548(1): 233 - 244. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help