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The Journal of Neuroscience, 2001, 21:RC190:1-6

RAPID COMMUNICATION
M5 Muscarinic Receptors Are Required for Prolonged Accumbal Dopamine Release after Electrical Stimulation of the Pons in Mice

Gina L. Forster¹, John S. Yeomans², Junichi Takeuchi³, and Charles D. Blaha¹

¹ Department of Psychology, Macquarie University, Sydney, New South Wales, Australia 2109, ² Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3, and ³ Department of Psychiatry, Yamanashi Medical University, Tamano, Yamanashi, Japan 409-3898

Midbrain dopamine neurons are activated directly by cholinergic agonists or by stimulation of the cholinergic neurons in the laterodorsal tegmental nucleus (LDT) of the pons in rats. In urethane-anesthetized mice, electrical stimulation of the LDT resulted in a rapid, stimulus-time-locked increase in dopamine release in the nucleus accumbens (NAc), followed several minutes later by a prolonged increase in dopamine release. In mutant mice with truncated M5 receptors, the prolonged phase of dopamine release was absent, but the initial, rapid phase of dopamine release was fully observed. We conclude that M5 muscarinic receptors on midbrain dopamine neurons mediate a prolonged facilitation of dopamine release in the NAc. These results imply that M5 muscarinic receptors play an important role in motivational behaviors driven by dopamine activity in the accumbens.

Key words: laterodorsal tegmental nucleus; scopolamine; acetylcholine; nucleus accumbens; reward; gene-targeted mice

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Copyright © Society for Neuroscience  0270-6474//$05.00/0

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