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The Journal of Neuroscience, May 15, 2002, 22(10):4025-4035
Aberrant Sensory Innervation of the Olfactory Bulb in
Neuropilin-2 Mutant Mice
Andreas
Walz,
Ivan
Rodriguez, and
Peter
Mombaerts
The Rockefeller University, New York, New York 10021
The mammalian olfactory system consists of two anatomically
segregated structures, the main olfactory system and the vomeronasal system, which each detect distinct types of chemical stimuli in the
environment. During development, sensory neurons establish precise
axonal connections with their respective targets within the olfactory
bulb. The specificity of the odorant or vomeronasal receptor expressed
by the sensory neuron is crucial in this process, yet it is less clear
which of the more conventional axon guidance molecules are involved.
Here, we show that neuropilin-2, a coreceptor for some of the class 3 semaphorins, is expressed in subpopulations of olfactory and
vomeronasal sensory neurons. We generated a knock-out mutation in the
neuropilin-2 gene by gene targeting in embryonic stem cells.
Neuropilin-2 mutant mice exhibit profound and distinct effects on
target innervation within the olfactory bulb. In the main olfactory
system, axons of olfactory sensory neurons penetrate into the deeper
layers of the main olfactory bulb. In the vomeronasal system, axonal
fasciculation within the vomeronasal nerve is affected; some axons are
misrouted and innervate glomeruli in an ectopic domain of the accessory
olfactory bulb.
Key words:
olfaction; smell; odor; olfactory bulb; vomeronasal
system; neuropilin; semaphorin; axon guidance
Copyright © 2002 Society for Neuroscience 0270-6474/02/22104025-11$05.00/0
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