QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (81) Citing Articles via Google Scholar Google Scholar Articles by Zwick, M. Articles by Albers, K. M. Search for Related Content PubMed PubMed Citation Articles by Zwick, M. Articles by Albers, K. M.

 Previous Article  |  Next Article 

The Journal of Neuroscience, May 15, 2002, 22(10):4057-4065

Glial Cell Line-Derived Neurotrophic Factor is a Survival Factor for Isolectin B4-Positive, but not Vanilloid Receptor 1-Positive, Neurons in the Mouse

Melissa Zwick¹, Brian M. Davis⁴, C. Jeffrey Woodbury³, John N. Burkett¹, H. Richard Koerber³, James F. Simpson², and Kathryn M. Albers⁴

Departments of ¹ Anatomy and Neurobiology and ² Pathology, University of Kentucky School of Medicine, Lexington, Kentucky 40536, and Departments of ³ Neurobiology and ⁴ Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261

Most, if not all, nociceptor sensory neurons are dependent on nerve growth factor (NGF) during early embryonic development. A large subpopulation of these sensory neurons loses NGF dependency between embryonic day 16 and postnatal day 14 and become responsive to glial cell line-derived growth factor (GDNF), a member of the transforming growth factor  (TGF-) family. To examine the survival and phenotypic effects of GDNF on sensory neurons in vivo, we generated transgenic mice that overexpress GDNF in the skin. GDNF-overexpresser mice had increased numbers of small unmyelinated sensory neurons that express the tyrosine kinase receptor Ret and bind the plant isolectin B4 (IB4). Surprisingly, in wild-type and transgenic mice, few (~2%) IB4-positive neurons expressed the vanilloid receptor VR1, a heat-sensitive receptor expressed by many IB4-positive neurons of the rat. Thus, in mouse, GDNF-dependent IB4-positive neurons must use a non-VR1 heat receptor. In addition, the behavior of GDNF-overexpresser animals to noxious heat or mechanical stimuli was indistinguishable from wild-type animals, indicating that, on a behavioral level, peripherally applied GDNF does not alter the sensitivity of the somatosensory system.

Key words: glial cell line-derived growth factor; transgenic mice; cutaneous; sensory neuron; somatosensory; development

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/22104057-09$05.00/0

This article has been cited by other articles:

				Y. Imai, K. Apakupakul, P. R. Krause, W. P. Halford, and T. P. Margolis Investigation of the Mechanism by Which Herpes Simplex Virus Type 1 LAT Sequences Modulate Preferential Establishment of Latent Infection in Mouse Trigeminal Ganglia J. Virol., August 15, 2009; 83(16): 7873 - 7882. [Abstract] [Full Text] [PDF]

				K. K. Rau, S. L. McIlwrath, H. Wang, J. J. Lawson, M. P. Jankowski, M. J. Zylka, D. J. Anderson, and H. R. Koerber Mrgprd Enhances Excitability in Specific Populations of Cutaneous Murine Polymodal Nociceptors J. Neurosci., July 1, 2009; 29(26): 8612 - 8619. [Abstract] [Full Text] [PDF]

				M. P. Jankowski, J. J. Lawson, S. L. McIlwrath, K. K. Rau, C. E. Anderson, K. M. Albers, and H. R. Koerber Sensitization of Cutaneous Nociceptors after Nerve Transection and Regeneration: Possible Role of Target-Derived Neurotrophic Factor Signaling J. Neurosci., February 11, 2009; 29(6): 1636 - 1647. [Abstract] [Full Text] [PDF]

				K. Schnizler, L. P. Shutov, M. J. Van Kanegan, M. A. Merrill, B. Nichols, G. S. McKnight, S. Strack, J. W. Hell, and Y. M. Usachev Protein Kinase A Anchoring via AKAP150 Is Essential for TRPV1 Modulation by Forskolin and Prostaglandin E2 in Mouse Sensory Neurons J. Neurosci., May 7, 2008; 28(19): 4904 - 4917. [Abstract] [Full Text] [PDF]

				T. J. Price, M. H. Rashid, M. Millecamps, R. Sanoja, J. M. Entrena, and F. Cervero Decreased Nociceptive Sensitization in Mice Lacking the Fragile X Mental Retardation Protein: Role of mGluR1/5 and mTOR J. Neurosci., December 19, 2007; 27(51): 13958 - 13967. [Abstract] [Full Text] [PDF]

				L.-Y. Chien, J.-K. Cheng, D. Chu, C.-F. Cheng, and M.-L. Tsaur Reduced Expression of A-Type Potassium Channels in Primary Sensory Neurons Induces Mechanical Hypersensitivity J. Neurosci., September 12, 2007; 27(37): 9855 - 9865. [Abstract] [Full Text] [PDF]

				K. M. Albers and B. M. Davis The Skin as a Neurotrophic Organ Neuroscientist, August 1, 2007; 13(4): 371 - 382. [Abstract] [PDF]

				J. Hjerling-Leffler, M. AlQatari, P. Ernfors, and M. Koltzenburg Emergence of Functional Sensory Subtypes as Defined by Transient Receptor Potential Channel Expression J. Neurosci., March 7, 2007; 27(10): 2435 - 2443. [Abstract] [Full Text] [PDF]

				K. Bielefeldt, F. Zhong, H. R. Koerber, and B. M. Davis Phenotypic characterization of gastric sensory neurons in mice Am J Physiol Gastrointest Liver Physiol, November 1, 2006; 291(5): G987 - G997. [Abstract] [Full Text] [PDF]

				C. M. Elitt, S. L. McIlwrath, J. J. Lawson, S. A. Malin, D. C. Molliver, P. K. Cornuet, H. R. Koerber, B. M. Davis, and K. M. Albers Artemin Overexpression in Skin Enhances Expression of TRPV1 and TRPA1 in Cutaneous Sensory Neurons and Leads to Behavioral Sensitivity to Heat and Cold. J. Neurosci., August 15, 2006; 26(33): 8578 - 8587. [Abstract] [Full Text] [PDF]

				S. A. Malin, D. C. Molliver, H. R. Koerber, P. Cornuet, R. Frye, K. M. Albers, and B. M. Davis Glial Cell Line-Derived Neurotrophic Factor Family Members Sensitize Nociceptors In Vitro and Produce Thermal Hyperalgesia In Vivo. J. Neurosci., August 15, 2006; 26(33): 8588 - 8599. [Abstract] [Full Text] [PDF]

				X. Fang, L. Djouhri, S. McMullan, C. Berry, S. G. Waxman, K. Okuse, and S. N. Lawson Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression. J. Neurosci., July 5, 2006; 26(27): 7281 - 7292. [Abstract] [Full Text] [PDF]

				K. M. Albers, C. J. Woodbury, A. M. Ritter, B. M. Davis, and H. R. Koerber Glial cell line-derived neurotrophic factor expression in skin alters the mechanical sensitivity of cutaneous nociceptors. J. Neurosci., March 15, 2006; 26(11): 2981 - 2990. [Abstract] [Full Text] [PDF]

				P. H. Lindfors, V. Voikar, J. Rossi, and M. S. Airaksinen Deficient Nonpeptidergic Epidermis Innervation and Reduced Inflammatory Pain in Glial Cell Line-Derived Neurotrophic Factor Family Receptor {alpha}2 Knock-Out Mice J. Neurosci., February 15, 2006; 26(7): 1953 - 1960. [Abstract] [Full Text] [PDF]

				T. B. Hucho, O. A. Dina, and J. D. Levine Epac Mediates a cAMP-to-PKC Signaling in Inflammatory Pain: An Isolectin B4(+) Neuron-Specific Mechanism J. Neurosci., June 29, 2005; 25(26): 6119 - 6126. [Abstract] [Full Text] [PDF]

				X. Fang, L. Djouhri, S. McMullan, C. Berry, K. Okuse, S. G. Waxman, and S. N. Lawson trkA Is Expressed in Nociceptive Neurons and Influences Electrophysiological Properties via Nav1.8 Expression in Rapidly Conducting Nociceptors J. Neurosci., May 11, 2005; 25(19): 4868 - 4878. [Abstract] [Full Text] [PDF]

				C. J. Woodbury, M. Zwick, S. Wang, J. J. Lawson, M. J. Caterina, M. Koltzenburg, K. M. Albers, H. R. Koerber, and B. M. Davis Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses J. Neurosci., July 14, 2004; 24(28): 6410 - 6415. [Abstract] [Full Text] [PDF]

				M. L. Nealen, M. S. Gold, P. D. Thut, and M. J. Caterina TRPM8 mRNA Is Expressed in a Subset of Cold-Responsive Trigeminal Neurons From Rat J Neurophysiol, July 1, 2003; 90(1): 515 - 520. [Abstract] [Full Text] [PDF]

				A. Hoke, T. Ho, T. O. Crawford, C. LeBel, D. Hilt, and J. W. Griffin Glial Cell Line-Derived Neurotrophic Factor Alters Axon Schwann Cell Units and Promotes Myelination in Unmyelinated Nerve Fibers J. Neurosci., January 15, 2003; 23(2): 561 - 567. [Abstract] [Full Text] [PDF]

				S. Dirajlal, L. E. Pauers, and C. L. Stucky Differential Response Properties of IB4-Positive and -Negative Unmyelinated Sensory Neurons to Protons and Capsaicin J Neurophysiol, January 1, 2003; 89(1): 513 - 524. [Abstract] [Full Text] [PDF]

				C. L Stucky, J. Rossi, M. S Airaksinen, and G. R Lewin GFR {alpha}2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons J. Physiol., November 15, 2002; 545(1): 43 - 50. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help