QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (30) Citing Articles via Google Scholar Google Scholar Articles by Kadish, I. Articles by van Groen, T. Search for Related Content PubMed PubMed Citation Articles by Kadish, I. Articles by van Groen, T.

 Previous Article  |  Next Article 

The Journal of Neuroscience, May 15, 2002, 22(10):4095-4102

Low Levels of Estrogen Significantly Diminish Axonal Sprouting after Entorhinal Cortex Lesions in the Mouse

Inga Kadish¹ and Thomas van Groen^{1, 2}

¹ Department of Neuroscience and Neurology, University of Kuopio, and ² Department of Neurology, Kuopio University Hospital, FIN 70211 Kuopio, Finland

This study tested the hypothesis that estrogen enhances axonal sprouting in the hippocampal formation in the female mouse. The entorhinal cortex was unilaterally lesioned with ibotenic acid in control mice and in ovariectomized mice that were treated with a high dose of, a moderate dose of, or zero estrogen supplementation pellets. Four weeks later the density of staining for synaptophysin immunoreactivity and acetylcholinesterase (AChE) histochemistry was measured in the molecular layer of the dentate gyrus. In control mice, lesions of the lateral part of the entorhinal cortex increased synaptophysin and acetylcholinesterase staining (i.e., indicative of axonal sprouting) in the outer one-third of the molecular layer of the dentate gyrus. Mice receiving high and moderate estrogen supplementation displayed the same sprouting response; however, in ovariectomized mice the sprouting response was significantly reduced (to nearly nothing). Thus, in ovariectomized compared with control mice the lesion-induced sprouting response is severely blunted, and this effect is reversed by estrogen supplementation. Together, these findings suggest that estrogen plays a prominent role in promoting neuronal plasticity and remodeling in the dentate gyrus.

Key words: estrogen; mice; hippocampal formation; limbic system; sex hormone; female

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/22104095-08$05.00/0

This article has been cited by other articles:

				I. Kadish, O. Thibault, E. M. Blalock, K.-C. Chen, J. C. Gant, N. M. Porter, and P. W. Landfield Hippocampal and Cognitive Aging across the Lifespan: A Bioenergetic Shift Precedes and Increased Cholesterol Trafficking Parallels Memory Impairment J. Neurosci., February 11, 2009; 29(6): 1805 - 1816. [Abstract] [Full Text] [PDF]

				A. M. Wong, I. Rozovsky, J. M. Arimoto, Y. Du, M. Wei, T. E. Morgan, and C. E. Finch Progesterone Influence on Neurite Outgrowth Involves Microglia Endocrinology, January 1, 2009; 150(1): 324 - 332. [Abstract] [Full Text] [PDF]

				J. C. Carroll, E. R. Rosario, L. Chang, F. Z. Stanczyk, S. Oddo, F. M. LaFerla, and C. J. Pike Progesterone and Estrogen Regulate Alzheimer-Like Neuropathology in Female 3xTg-AD Mice J. Neurosci., November 28, 2007; 27(48): 13357 - 13365. [Abstract] [Full Text] [PDF]

				W. B. Rowe, E. M. Blalock, K.-C. Chen, I. Kadish, D. Wang, J. E. Barrett, O. Thibault, N. M. Porter, G. M. Rose, and P. W. Landfield Hippocampal Expression Analyses Reveal Selective Association of Immediate-Early, Neuroenergetic, and Myelinogenic Pathways with Cognitive Impairment in Aged Rats J. Neurosci., March 21, 2007; 27(12): 3098 - 3110. [Abstract] [Full Text] [PDF]

				M. Febo, C. F. Ferris, and A. C. Segarra Estrogen Influences Cocaine-Induced Blood Oxygen Level-Dependent Signal Changes in Female Rats J. Neurosci., February 2, 2005; 25(5): 1132 - 1136. [Abstract] [Full Text] [PDF]

				J.-M. Rakic, V. Lambert, M. Deprez, J.-M. Foidart, A. Noel, and C. Munaut Estrogens Reduce the Expression of YKL-40 in the Retina: Implications for Eye and Joint Diseases Invest. Ophthalmol. Vis. Sci., April 1, 2003; 44(4): 1740 - 1746. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help