 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, May 15, 2002, 22(10):4114-4131
Nonlinear Spectrotemporal Sound Analysis by Neurons in the Auditory Midbrain
Monty A. Escabí1, 2 and Christoph E. Schreiner1 1 W. M. Keck Center for Integrative Neuroscience and University of California San Francisco/University of California Berkeley Joint Bioengineering Graduate Group, University of California, San Francisco, California 94143, and 2 Department of Electrical and Computer Engineering, Biomedical Engineering Program, University of Connecticut, Storrs, Connecticut 06269
The auditory system of humans and animals must process information from sounds that dynamically vary along multiple stimulus dimensions, including time, frequency, and intensity. Therefore, to understand neuronal mechanisms underlying acoustic processing in the central auditory pathway, it is essential to characterize how spectral and temporal acoustic dimensions are jointly processed by the brain. We use acoustic signals with a structurally rich time-varying spectrum to study linear and nonlinear spectrotemporal interactions in the central nucleus of the inferior colliculus (ICC). Our stimuli, the dynamic moving ripple (DMR) and ripple noise (RN), allow us to systematically characterize response attributes with the spectrotemporal receptive field (STRF) methods to a rich and dynamic stimulus ensemble. Theoretically, we expect that STRFs derived with DMR and RN would be identical for a linear integrating neuron, and we find that ~60% of ICC neurons meet this basic requirement. We find that the remaining neurons are distinctly nonlinear; these could either respond selectively to DMR or produce no STRFs despite selective activation to spectrotemporal acoustic attributes. Our findings delineate rules for spectrotemporal integration in the ICC that cannot be accounted for by conventional linear-energy integration models.
Key words: inferior colliculus; spectrotemporal; receptive field; nonlinear; ripple; naturalistic; reverse correlation
Copyright © 2002 Society for Neuroscience 0270-6474/02/22104114-18$05.00/0
This article has been cited by other articles:
G. D. Grana, C. P. Billimoria, and K. Sen
Analyzing Variability in Neural Responses to Complex Natural Sounds in the Awake Songbird
J Neurophysiol, June 1, 2009; 101(6): 3147 - 3157.
[Abstract] [Full Text] [PDF]
S. M. N. Woolley, P. R. Gill, T. Fremouw, and F. E. Theunissen
Functional Groups in the Avian Auditory System
J. Neurosci., March 4, 2009; 29(9): 2780 - 2793.
[Abstract] [Full Text] [PDF]
L. Qin, J. Wang, and Y. Sato
Heterogeneous Neuronal Responses to Frequency-Modulated Tones in the Primary Auditory Cortex of Awake Cats
J Neurophysiol, September 1, 2008; 100(3): 1622 - 1634.
[Abstract] [Full Text] [PDF]
P. Gill, S. M. N. Woolley, T. Fremouw, and F. E. Theunissen
What's That Sound? Auditory Area CLM Encodes Stimulus Surprise, Not Intensity or Intensity Changes
J Neurophysiol, June 1, 2008; 99(6): 2809 - 2820.
[Abstract] [Full Text] [PDF]
N. A. Lesica and B. Grothe
Dynamic Spectrotemporal Feature Selectivity in the Auditory Midbrain
J. Neurosci., May 21, 2008; 28(21): 5412 - 5421.
[Abstract] [Full Text] [PDF]
C. A. Atencio and C. E. Schreiner
Spectrotemporal Processing Differences between Auditory Cortical Fast-Spiking and Regular-Spiking Neurons
J. Neurosci., April 9, 2008; 28(15): 3897 - 3910.
[Abstract] [Full Text] [PDF]
G. B. Christianson, M. Sahani, and J. F. Linden
The Consequences of Response Nonlinearities for Interpretation of Spectrotemporal Receptive Fields
J. Neurosci., January 9, 2008; 28(2): 446 - 455.
[Abstract] [Full Text] [PDF]
S. Bandyopadhyay, L. A. J. Reiss, and E. D. Young
Receptive Field for Dorsal Cochlear Nucleus Neurons at Multiple Sound Levels
J Neurophysiol, December 1, 2007; 98(6): 3505 - 3515.
[Abstract] [Full Text] [PDF]
L. A. J. Reiss, S. Bandyopadhyay, and E. D. Young
Effects of Stimulus Spectral Contrast on Receptive Fields of Dorsal Cochlear Nucleus Neurons
J Neurophysiol, October 1, 2007; 98(4): 2133 - 2143.
[Abstract] [Full Text] [PDF]
C. A. Atencio, D. T. Blake, F. Strata, S. W. Cheung, M. M. Merzenich, and C. E. Schreiner
Frequency-Modulation Encoding in the Primary Auditory Cortex of the Awake Owl Monkey
J Neurophysiol, October 1, 2007; 98(4): 2182 - 2195.
[Abstract] [Full Text] [PDF]
R. Xie, J. X. Gittelman, and G. D. Pollak
Rethinking Tuning: In Vivo Whole-Cell Recordings of the Inferior Colliculus in Awake Bats
J. Neurosci., August 29, 2007; 27(35): 9469 - 9481.
[Abstract] [Full Text] [PDF]
S. Andoni, N. Li, and G. D. Pollak
Spectrotemporal Receptive Fields in the Inferior Colliculus Revealing Selectivity for Spectral Motion in Conspecific Vocalizations
J. Neurosci., May 2, 2007; 27(18): 4882 - 4893.
[Abstract] [Full Text] [PDF]
E. L. Bartlett and X. Wang
Neural Representations of Temporally Modulated Signals in the Auditory Thalamus of Awake Primates
J Neurophysiol, February 1, 2007; 97(2): 1005 - 1017.
[Abstract] [Full Text] [PDF]
Y. E. Cohen, F. Theunissen, B. E. Russ, and P. Gill
Acoustic Features of Rhesus Vocalizations and Their Representation in the Ventrolateral Prefrontal Cortex
J Neurophysiol, February 1, 2007; 97(2): 1470 - 1484.
[Abstract] [Full Text] [PDF]
B. B. Averbeck and L. M. Romanski
Probabilistic Encoding of Vocalizations in Macaque Ventral Lateral Prefrontal Cortex
J. Neurosci., October 25, 2006; 26(43): 11023 - 11033.
[Abstract] [Full Text] [PDF]
S. M. N. Woolley, P. R. Gill, and F. E. Theunissen
Stimulus-Dependent Auditory Tuning Results in Synchronous Population Coding of Vocalizations in the Songbird Midbrain
J. Neurosci., March 1, 2006; 26(9): 2499 - 2512.
[Abstract] [Full Text] [PDF]
E. D. Young and B. M. Calhoun
Nonlinear Modeling of Auditory-Nerve Rate Responses to Wideband Stimuli
J Neurophysiol, December 1, 2005; 94(6): 4441 - 4454.
[Abstract] [Full Text] [PDF]
M. A. Escabi, R. Nassiri, L. M. Miller, C. E. Schreiner, and H. L. Read
The Contribution of Spike Threshold to Acoustic Feature Selectivity, Spike Information Content, and Information Throughput
J. Neurosci., October 12, 2005; 25(41): 9524 - 9534.
[Abstract] [Full Text] [PDF]
B. Godey, C. A. Atencio, B. H. Bonham, C. E. Schreiner, and S. W. Cheung
Functional Organization of Squirrel Monkey Primary Auditory Cortex: Responses to Frequency-Modulation Sweeps
J Neurophysiol, August 1, 2005; 94(2): 1299 - 1311.
[Abstract] [Full Text] [PDF]
A. J. Norena and J. J. Eggermont
Enriched Acoustic Environment after Noise Trauma Reduces Hearing Loss and Prevents Cortical Map Reorganization
J. Neurosci., January 19, 2005; 25(3): 699 - 705.
[Abstract] [Full Text] [PDF]
A. Hsu, S. M. N. Woolley, T. E. Fremouw, and F. E. Theunissen
Modulation Power and Phase Spectrum of Natural Sounds Enhance Neural Encoding Performed by Single Auditory Neurons
J. Neurosci., October 13, 2004; 24(41): 9201 - 9211.
[Abstract] [Full Text] [PDF]
M. N. Kvale and C. E. Schreiner
Short-Term Adaptation of Auditory Receptive Fields to Dynamic Stimuli
J Neurophysiol, February 1, 2004; 91(2): 604 - 612.
[Abstract] [Full Text] [PDF]
M. A. Escabi, L. M. Miller, H. L. Read, and C. E. Schreiner
Naturalistic Auditory Contrast Improves Spectrotemporal Coding in the Cat Inferior Colliculus
J. Neurosci., December 17, 2003; 23(37): 11489 - 11504.
[Abstract] [Full Text] [PDF]
J. F. Linden, R. C. Liu, M. Sahani, C. E. Schreiner, and M. M. Merzenich
Spectrotemporal Structure of Receptive Fields in Areas AI and AAF of Mouse Auditory Cortex
J Neurophysiol, October 1, 2003; 90(4): 2660 - 2675.
[Abstract] [Full Text] [PDF]
D. A. Schwartz, C. Q. Howe, and D. Purves
The Statistical Structure of Human Speech Sounds Predicts Musical Universals
J. Neurosci., August 6, 2003; 23(18): 7160 - 7168.
[Abstract] [Full Text] [PDF]
A. Qiu, C. E. Schreiner, and M. A. Escabi
Gabor Analysis of Auditory Midbrain Receptive Fields: Spectro-Temporal and Binaural Composition
J Neurophysiol, July 1, 2003; 90(1): 456 - 476.
[Abstract] [Full Text] [PDF]
J. A. Grace, N. Amin, N. C. Singh, and F. E. Theunissen
Selectivity for Conspecific Song in the Zebra Finch Auditory Forebrain
J Neurophysiol, January 1, 2003; 89(1): 472 - 487.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|