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The Journal of Neuroscience, May 15, 2002, 22(10):4241-4247

Variation in Inter-Animal Susceptibility to Noise Damage Is Associated with 9 Acetylcholine Receptor Subunit Expression Level

Anne E. Luebke^{1, 2} and Paul K. Foster¹

¹ Department of Otolaryngology and ² Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136

Large intersubject variabilities in acoustic injury are known to occur in both humans and animals; however, the mechanisms underlying such differences are poorly understood. The olivocochlear efferent system has been hypothesized to play a significant role in protecting the cochlea from noise overexposure. In this study, we demonstrate that a newly developed test for determining average efferent system strength can predict intersubject variations in acoustic injury. In addition, the intersubject variability in cochlear expression of the 9 subunit of the nicotinic acetylcholine receptor was found to be proportional to an animals average efferent strength. Therefore, the inter-animal variability in the 9-containing acetylcholine receptor expression may be one mechanism contributing to the inter-animal variability in acoustic injury.

Key words: efferent; cochlea; hair cells; 9 subunit of the nicotinic acetylcholine receptor; distortion-product otoacoustic emissions; fast-adaptation; noise-induced hearing loss; noise susceptibility

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22104241-07$05.00/0

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