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The Journal of Neuroscience, June 1, 2002, 22(11):4663-4669

Anterograde Amnesia and Temporally Graded Retrograde Amnesia for a Nonspatial Memory Task after Lesions of Hippocampus and Subiculum

Robert E. Clark¹, Nicola J. Broadbent¹, Stuart M. Zola^{1, 2, 4}, and Larry R. Squire^{1, 2, 3, 4}

Departments of ¹ Psychiatry, ² Neurosciences, and ³ Psychology, University of California, La Jolla, California 92993, and ⁴ Veterans Affairs Medical Center, San Diego, California 92161

We studied the importance of the hippocampus and subiculum for anterograde and retrograde memory in the rat using social transmission of food preference, a nonspatial memory task. Experiment 1 asked how long an acquired food preference could be remembered. In experiment 2, we determined the anterograde amnesic effects of large lesions of the hippocampus that included the subiculum. In experiment 3, large lesions of the hippocampus that included the subiculum were made 1, 10, or 30 d after learning to determine the nature and extent of retrograde amnesia. Normal rats exhibited memory of the acquired food preference for at least 3 months after learning. Hippocampal lesions that included the subiculum produced marked anterograde amnesia and a 1-30 d temporally graded retrograde amnesia. The results show the importance of the hippocampus and related structures for nonspatial memory and also demonstrate the temporary role of these structures in long-term memory.

Key words: anterograde; retrograde; temporally graded; hippocampus; subiculum; social transmission; food preference; rat

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22114663-07$05.00/0

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