QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (47) Citing Articles via Google Scholar Google Scholar Articles by Zygmunt, P. M. Articles by Högestätt, E. D. Search for Related Content PubMed PubMed Citation Articles by Zygmunt, P. M. Articles by Högestätt, E. D. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL CAPSAICIN TETRAHYDROCANNABINOL

 Previous Article  |  Next Article 

The Journal of Neuroscience, June 1, 2002, 22(11):4720-4727

⁹-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB₁ and CB₂ Cannabinoid Receptor-Independent Mechanism

Peter M. Zygmunt, David A. Andersson, and Edward D. Högestätt

Department of Clinical Pharmacology, Institute of Laboratory Medicine, Lund University Hospital, SE-221 85 Lund, Sweden

Although ⁹-tetrahydrocannabinol (THC) produces analgesia, its effects on nociceptive primary afferents are unknown. These neurons participate not only in pain signaling but also in the local response to tissue injury. Here, we show that THC and cannabinol induce a CB₁/CB₂ cannabinoid receptor-independent release of calcitonin gene-related peptide from capsaicin-sensitive perivascular sensory nerves. Other psychotropic cannabinoids cannot mimic this action. The vanilloid receptor antagonist ruthenium red abolishes the responses to THC and cannabinol. However, the effect of THC on sensory nerves is intact in vanilloid receptor subtype 1 gene knock-out mice. The THC response depends on extracellular calcium but does not involve known voltage-operated calcium channels, glutamate receptors, or protein kinases A and C. These results may indicate the presence of a novel cannabinoid receptor/ion channel in the pain pathway.

Key words: calcitonin gene-related peptide; cannabinoids; cannabinol; cannabis; capsaicin; nociceptors; pain; receptors, sensory; tetrahydrocannabinol

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/22114720-08$05.00/0

This article has been cited by other articles:

				A. E. B. Springs, P. W. F. Karmaus, R. B. Crawford, B. L. F. Kaplan, and N. E. Kaminski Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by {Delta}9-tetrahydrocannabinol J. Leukoc. Biol., December 1, 2008; 84(6): 1574 - 1584. [Abstract] [Full Text] [PDF]

				N. Qin, M. P. Neeper, Y. Liu, T. L. Hutchinson, M. L. Lubin, and C. M. Flores TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons J. Neurosci., June 11, 2008; 28(24): 6231 - 6238. [Abstract] [Full Text] [PDF]

				L. De Petrocellis, V. Vellani, A. Schiano-Moriello, P. Marini, P. C. Magherini, P. Orlando, and V. Di Marzo Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8 J. Pharmacol. Exp. Ther., June 1, 2008; 325(3): 1007 - 1015. [Abstract] [Full Text] [PDF]

				A.H. Taylor, C. Ang, S.C. Bell, and J.C. Konje The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy Hum. Reprod. Update, September 1, 2007; 13(5): 501 - 513. [Abstract] [Full Text] [PDF]

				E. D. Giudice, L. Rinaldi, M. Passarotto, F. Facchinetti, A. D'Arrigo, A. Guiotto, M. D. Carbonare, L. Battistin, and A. Leon Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells J. Leukoc. Biol., June 1, 2007; 81(6): 1512 - 1522. [Abstract] [Full Text] [PDF]

				S. E. O'Sullivan, M. D. Randall, and S. M. Gardiner The in Vitro and in Vivo Cardiovascular Effects of {Delta}9-Tetrahydrocannabinol in Rats Made Hypertensive by Chronic Inhibition of Nitric-Oxide Synthase J. Pharmacol. Exp. Ther., May 1, 2007; 321(2): 663 - 672. [Abstract] [Full Text] [PDF]

				S. E. O'Sullivan, D. A. Kendall, and M. D. Randall Further Characterization of the Time-Dependent Vascular Effects of {Delta}9-Tetrahydrocannabinol J. Pharmacol. Exp. Ther., April 1, 2006; 317(1): 428 - 438. [Abstract] [Full Text] [PDF]

				P. Movahed, B. A. G. Jonsson, B. Birnir, J. A. Wingstrand, T. D. Jorgensen, A. Ermund, O. Sterner, P. M. Zygmunt, and E. D. Hogestatt Endogenous Unsaturated C18 N-Acylethanolamines Are Vanilloid Receptor (TRPV1) Agonists J. Biol. Chem., November 18, 2005; 280(46): 38496 - 38504. [Abstract] [Full Text] [PDF]

				D. M. Bautista, P. Movahed, A. Hinman, H. E. Axelsson, O. Sterner, E. D. Hogestatt, D. Julius, S.-E. Jordt, and P. M. Zygmunt Pungent products from garlic activate the sensory ion channel TRPA1 PNAS, August 23, 2005; 102(34): 12248 - 12252. [Abstract] [Full Text] [PDF]

				M. Duncan, D. A. Kendall, and V. Ralevic Characterization of Cannabinoid Modulation of Sensory Neurotransmission in the Rat Isolated Mesenteric Arterial Bed J. Pharmacol. Exp. Ther., October 1, 2004; 311(1): 411 - 419. [Abstract] [Full Text] [PDF]

				P. Pacher, S. Batkai, and G. Kunos Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice J. Physiol., July 15, 2004; 558(2): 647 - 657. [Abstract] [Full Text] [PDF]

				G. Dubrovska, S. Verlohren, F. C. Luft, and M. Gollasch Mechanisms of ADRF release from rat aortic adventitial adipose tissue Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1107 - H1113. [Abstract] [Full Text] [PDF]

				L. Offertaler, F.-M. Mo, S. Batkai, J. Liu, M. Begg, R. K. Razdan, B. R. Martin, R. D. Bukoski, and G. Kunos Selective Ligands and Cellular Effectors of a G Protein-Coupled Endothelial Cannabinoid Receptor Mol. Pharmacol., March 1, 2003; 63(3): 699 - 705. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help