 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, June 15, 2002, 22(12):4860-4868
Protein Kinase Modulation of Dendritic K+ Channels in Hippocampus Involves a Mitogen-Activated Protein Kinase Pathway
Li-Lian Yuan, J. Paige Adams, Michael Swank, J. David Sweatt, and Daniel Johnston Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
We investigated mitogen-activated protein kinase (MAPK) modulation of dendritic, A-type K+ channels in CA1 pyramidal neurons in the hippocampus. Activation of cAMP-dependent protein kinase A (PKA) and protein kinase C (PKC) leads to an increase in the amplitude of backpropagating action potentials in distal dendrites through downregulation of transient K+ channels in CA1 pyramidal neurons in the hippocampus. We show here that both of these signaling pathways converge on extracellular-regulated kinases (ERK)-specific MAPK in mediating this reduction in dendritic K+ current, which is confirmed, in parallel, by biochemical assays using phosphospecific antibodies against the ppERK and pKv4.2. Furthermore, immunostaining indicates dendritic localization of ppERK and pKv4.2. Taken together, these results demonstrate that dendritic, A-type K+ channels are dually regulated by PKA and PKC through a common downstream pathway involving MAPK, and the modulation of these K+ channels may be accounted for by the phosphorylation of Kv4.2 subunits.
Key words: dendrite; A-type K+ channel; MAPK; PKA; PKC; hippocampus
Copyright © 2002 Society for Neuroscience 0270-6474/02/22124860-09$05.00/0
This article has been cited by other articles:
P. Deng, Z.-P. Pang, Z. Lei, and Z. C. Xu
Excitatory Roles of Protein Kinase C in Striatal Cholinergic Interneurons
J Neurophysiol, October 1, 2009; 102(4): 2453 - 2461.
[Abstract] [Full Text] [PDF]
H. Vara, F. Onofri, F. Benfenati, M. Sassoe-Pognetto, and M. Giustetto
ERK activation in axonal varicosities modulates presynaptic plasticity in the CA3 region of the hippocampus through synapsin I
PNAS, June 16, 2009; 106(24): 9872 - 9877.
[Abstract] [Full Text] [PDF]
J. C. Alexander, C. M. McDermott, T. Tunur, V. Rands, C. Stelly, D. Karhson, M. R. Bowlby, W. F. An, J. D. Sweatt, and L. A. Schrader
The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning
Learn. Mem., February 17, 2009; 16(3): 167 - 177.
[Abstract] [Full Text] [PDF]
O. Sovik, S. Schubbert, G. Houge, S. J Steine, G. Norgard, B. Engelsen, P. R Njolstad, K. Shannon, and A. Molven
De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features
BMJ Case Reports, January 22, 2009; 2009(jan21_1): bcr0720080550 - bcr0720080550.
[Abstract] [Full Text]
J. A. Rosenkranz, A. Frick, and D. Johnston
Kinase-dependent modification of dendritic excitability after long-term potentiation
J. Physiol., January 1, 2009; 587(1): 115 - 125.
[Abstract] [Full Text] [PDF]
Y.-Q. Li, F.-Q. Li, X.-Y. Wang, P. Wu, M. Zhao, C.-M. Xu, Y. Shaham, and L. Lu
Central Amygdala Extracellular Signal-Regulated Kinase Signaling Pathway Is Critical to Incubation of Opiate Craving
J. Neurosci., December 3, 2008; 28(49): 13248 - 13257.
[Abstract] [Full Text] [PDF]
M. Day, D. Wokosin, J. L. Plotkin, X. Tian, and D. J. Surmeier
Differential Excitability and Modulation of Striatal Medium Spiny Neuron Dendrites
J. Neurosci., November 5, 2008; 28(45): 11603 - 11614.
[Abstract] [Full Text] [PDF]
L. Y. Teos, A. Zhao, Z. Alvin, G. G. Laurence, C. Li, and G. E. Haddad
Basal and IGF-I-dependent regulation of potassium channels by MAP kinases and PI3-kinase during eccentric cardiac hypertrophy
Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H1834 - H1845.
[Abstract] [Full Text] [PDF]
J. Kim, M. S. Nadal, A. M. Clemens, M. Baron, S.-C. Jung, Y. Misumi, B. Rudy, and D. A. Hoffman
Kv4 Accessory Protein DPPX (DPP6) is a Critical Regulator of Membrane Excitability in Hippocampal CA1 Pyramidal Neurons
J Neurophysiol, October 1, 2008; 100(4): 1835 - 1847.
[Abstract] [Full Text] [PDF]
M. Fry, G. T. Cottrell, and A. V. Ferguson
Prokineticin 2 influences subfornical organ neurons through regulation of MAP kinase and the modulation of sodium channels
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R848 - R856.
[Abstract] [Full Text] [PDF]
H. Misonou, S. M. Thompson, and X. Cai
Dynamic Regulation of the Kv2.1 Voltage-Gated Potassium Channel during Brain Ischemia through Neuroglial Interaction
J. Neurosci., August 20, 2008; 28(34): 8529 - 8538.
[Abstract] [Full Text] [PDF]
R. S. Hammond, L. Lin, M. S. Sidorov, A. M. Wikenheiser, and D. A. Hoffman
Protein Kinase A Mediates Activity-Dependent Kv4.2 Channel Trafficking
J. Neurosci., July 23, 2008; 28(30): 7513 - 7519.
[Abstract] [Full Text] [PDF]
J. Kim and D. A. Hoffman
Potassium Channels: Newly Found Players in Synaptic Plasticity
Neuroscientist, June 1, 2008; 14(3): 276 - 286.
[Abstract] [PDF]
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]
M. W. Shiflett, R. P. Martini, J. C. Mauna, R. L. Foster, E. Peet, and E. Thiels
Cue-Elicited Reward-Seeking Requires Extracellular Signal-Regulated Kinase Activation in the Nucleus Accumbens
J. Neurosci., February 6, 2008; 28(6): 1434 - 1443.
[Abstract] [Full Text] [PDF]
W. Morishita and R. C. Malenka
Mechanisms Underlying Dedepression of Synaptic NMDA Receptors in the Hippocampus
J Neurophysiol, January 1, 2008; 99(1): 254 - 263.
[Abstract] [Full Text] [PDF]
H.-J. Hu, B. J. Alter, Y. Carrasquillo, C.-S. Qiu, and R. W. Gereau IV
Metabotropic Glutamate Receptor 5 Modulates Nociceptive Plasticity via Extracellular Signal-Regulated Kinase Kv4.2 Signaling in Spinal Cord Dorsal Horn Neurons
J. Neurosci., November 28, 2007; 27(48): 13181 - 13191.
[Abstract] [Full Text] [PDF]
S. I. Cohen-Matsliah, I. Brosh, K. Rosenblum, and E. Barkai
A Novel Role for Extracellular Signal-Regulated Kinase in Maintaining Long-Term Memory-Relevant Excitability Changes
J. Neurosci., November 14, 2007; 27(46): 12584 - 12589.
[Abstract] [Full Text] [PDF]
J. S. Wiegert, C. P. Bengtson, and H. Bading
Diffusion and Not Active Transport Underlies and Limits ERK1/2 Synapse-to-Nucleus Signaling in Hippocampal Neurons
J. Biol. Chem., October 5, 2007; 282(40): 29621 - 29633.
[Abstract] [Full Text] [PDF]
O. Sovik, S. Schubbert, G. Houge, S. J Steine, G. Norgard, B. Engelsen, P. R Njolstad, K. Shannon, and A. Molven
De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features
J. Med. Genet., July 1, 2007; 44(7): e84 - e84.
[Abstract] [Full Text] [PDF]
P. Tsokas, T. Ma, R. Iyengar, E. M. Landau, and R. D. Blitzer
Mitogen-Activated Protein Kinase Upregulates the Dendritic Translation Machinery in Long-Term Potentiation by Controlling the Mammalian Target of Rapamycin Pathway
J. Neurosci., May 30, 2007; 27(22): 5885 - 5894.
[Abstract] [Full Text] [PDF]
P. T. Redman, K. He, K. A. Hartnett, B. S. Jefferson, L. Hu, P. A. Rosenberg, E. S. Levitan, and E. Aizenman
Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1
PNAS, February 27, 2007; 104(9): 3568 - 3573.
[Abstract] [Full Text] [PDF]
Y. Carrasquillo and R. W. Gereau IV
Activation of the Extracellular Signal-Regulated Kinase in the Amygdala Modulates Pain Perception
J. Neurosci., February 14, 2007; 27(7): 1543 - 1551.
[Abstract] [Full Text] [PDF]
A. Ruiz-Gomez, B. Mellstrom, D. Tornero, E. Morato, M. Savignac, H. Holguin, K. Aurrekoetxea, P. Gonzalez, C. Gonzalez-Garcia, V. Cena, et al.
G Protein-coupled Receptor Kinase 2-mediated Phosphorylation of Downstream Regulatory Element Antagonist Modulator Regulates Membrane Trafficking of Kv4.2 Potassium Channel
J. Biol. Chem., January 12, 2007; 282(2): 1205 - 1215.
[Abstract] [Full Text] [PDF]
G. A. B. Armstrong, K. L. Shoemaker, T. G. A. Money, and R. M. Robertson
Octopamine Mediates Thermal Preconditioning of the Locust Ventilatory Central Pattern Generator via a cAMP/Protein Kinase A Signaling Pathway.
J. Neurosci., November 22, 2006; 26(47): 12118 - 12126.
[Abstract] [Full Text] [PDF]
X. Chen, L.-L. Yuan, C. Zhao, S. G. Birnbaum, A. Frick, W. E. Jung, T. L. Schwarz, J. D. Sweatt, and D. Johnston
Deletion of Kv4.2 Gene Eliminates Dendritic A-Type K+ Current and Enhances Induction of Long-Term Potentiation in Hippocampal CA1 Pyramidal Neurons.
J. Neurosci., November 22, 2006; 26(47): 12143 - 12151.
[Abstract] [Full Text] [PDF]
G. L. Fawcett, C. M. Santi, A. Butler, T. Harris, M. Covarrubias, and L. Salkoff
Mutant Analysis of the Shal (Kv4) Voltage-gated Fast Transient K+ Channel in Caenorhabditis elegans
J. Biol. Chem., October 13, 2006; 281(41): 30725 - 30735.
[Abstract] [Full Text] [PDF]
H. S. Ahn, S. E. Kim, H.-J. Jang, M.-J. Kim, D.-J. Rhie, S.-H. Yoon, Y.-H. Jo, M.-S. Kim, K.-W. Sung, and S. J. Hahn
Interaction of Riluzole with the Closed Inactivated State of Kv4.3 Channels
J. Pharmacol. Exp. Ther., October 1, 2006; 319(1): 323 - 331.
[Abstract] [Full Text] [PDF]
Y. H. Zhang, J. C. Fehrenbacher, M. R. Vasko, and G. D. Nicol
Sphingosine-1-Phosphate Via Activation of a G-Protein-Coupled Receptor(s) Enhances the Excitability of Rat Sensory Neurons
J Neurophysiol, September 1, 2006; 96(3): 1042 - 1052.
[Abstract] [Full Text] [PDF]
R. Bianchi, S.-C. Chuang, and R. K. S. Wong
Pharmacology of a Slowly Inactivating Outward Current in Hippocampal CA3 Pyramidal Neurons
J Neurophysiol, September 1, 2006; 96(3): 1116 - 1123.
[Abstract] [Full Text] [PDF]
L. Topolnik, M. Azzi, F. Morin, A. Kougioumoutzakis, and J.-C. Lacaille
mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones
J. Physiol., August 15, 2006; 575(1): 115 - 131.
[Abstract] [Full Text] [PDF]
S. M. Ajay and U. S. Bhalla
Synaptic plasticity in vitro and in silico: insights into an intracellular signaling maze.
Physiology, August 1, 2006; 21: 289 - 296.
[Abstract] [Full Text] [PDF]
N. P. Poolos, J. B. Bullis, and M. K. Roth
Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase.
J. Neurosci., July 26, 2006; 26(30): 7995 - 8003.
[Abstract] [Full Text] [PDF]
L. A. Schrader, S. G. Birnbaum, B. M. Nadin, Y. Ren, D. Bui, A. E. Anderson, and J. D. Sweatt
ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit
Am J Physiol Cell Physiol, March 1, 2006; 290(3): C852 - C861.
[Abstract] [Full Text] [PDF]
V. Iyer, T. M. Hoogland, and P. Saggau
Fast Functional Imaging of Single Neurons Using Random-Access Multiphoton (RAMP) Microscopy
J Neurophysiol, January 1, 2006; 95(1): 535 - 545.
[Abstract] [Full Text] [PDF]
L.-L. Yuan, X. Chen, K. Kunjilwar, P. Pfaffinger, and D. Johnston
Acceleration of K+ channel inactivation by MEK inhibitor U0126
Am J Physiol Cell Physiol, January 1, 2006; 290(1): C165 - C171.
[Abstract] [Full Text] [PDF]
S. Khavandgar, J. T. Walter, K. Sageser, and K. Khodakhah
Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells
J. Physiol., December 1, 2005; 569(2): 545 - 557.
[Abstract] [Full Text] [PDF]
J. Kim, D.-S. Wei, and D. A. Hoffman
Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones
J. Physiol., November 15, 2005; 569(1): 41 - 57.
[Abstract] [Full Text] [PDF]
S. A. Kushner, Y. Elgersma, G. G. Murphy, D. Jaarsma, G. M. van Woerden, M. R. Hojjati, Y. Cui, J. C. LeBoutillier, D. F. Marrone, E. S. Choi, et al.
Modulation of Presynaptic Plasticity and Learning by the H-ras/Extracellular Signal-Regulated Kinase/Synapsin I Signaling Pathway
J. Neurosci., October 19, 2005; 25(42): 9721 - 9734.
[Abstract] [Full Text] [PDF]
W. Yuan, A. Burkhalter, and J. M. Nerbonne
Functional Role of the Fast Transient Outward K+ Current IA in Pyramidal Neurons in (Rat) Primary Visual Cortex
J. Neurosci., October 5, 2005; 25(40): 9185 - 9194.
[Abstract] [Full Text] [PDF]
G. M. Sutton, B. Duos, L. M. Patterson, and H.-R. Berthoud
Melanocortinergic Modulation of Cholecystokinin-Induced Suppression of Feeding through Extracellular Signal-Regulated Kinase Signaling in Rat Solitary Nucleus
Endocrinology, September 1, 2005; 146(9): 3739 - 3747.
[Abstract] [Full Text] [PDF]
K. L. Hillman, V. A. Doze, and J. E. Porter
Functional Characterization of the {beta}-Adrenergic Receptor Subtypes Expressed by CA1 Pyramidal Cells in the Rat Hippocampus
J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 561 - 567.
[Abstract] [Full Text] [PDF]
E. K. Wittmack, A. M. Rush, A. Hudmon, S. G. Waxman, and S. D. Dib-Hajj
Voltage-Gated Sodium Channel Nav1.6 Is Modulated by p38 Mitogen-Activated Protein Kinase
J. Neurosci., July 13, 2005; 25(28): 6621 - 6630.
[Abstract] [Full Text] [PDF]
F. J. Nasif, K. Sidiropoulou, X.-T. Hu, and F. J. White
Repeated Cocaine Administration Increases Membrane Excitability of Pyramidal Neurons in the Rat Medial Prefrontal Cortex
J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 1305 - 1313.
[Abstract] [Full Text] [PDF]
D.-Y. He, N. N. H. McGough, A. Ravindranathan, J. Jeanblanc, M. L. Logrip, K. Phamluong, P. H. Janak, and D. Ron
Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption
J. Neurosci., January 19, 2005; 25(3): 619 - 628.
[Abstract] [Full Text] [PDF]
J.-C. Corvol, E. Valjent, M. Toutant, H. Enslen, T. Irinopoulou, S. Lev, D. Herve, and J.-A. Girault
Depolarization Activates ERK and Proline-rich Tyrosine Kinase 2 (PYK2) Independently in Different Cellular Compartments in Hippocampal Slices
J. Biol. Chem., January 7, 2005; 280(1): 660 - 668.
[Abstract] [Full Text] [PDF]
G. M. Sutton, L. M. Patterson, and H.-R. Berthoud
Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Solitary Nucleus Mediates Cholecystokinin-Induced Suppression of Food Intake in Rats
J. Neurosci., November 10, 2004; 24(45): 10240 - 10247.
[Abstract] [Full Text] [PDF]
X.-T. Hu, S. Basu, and F. J. White
Repeated Cocaine Administration Suppresses HVA-Ca2+ Potentials and Enhances Activity of K+ Channels in Rat Nucleus Accumbens Neurons
J Neurophysiol, September 1, 2004; 92(3): 1597 - 1607.
[Abstract] [Full Text] [PDF]
H.-Y. Cheng and D. F. Clayton
Activation and Habituation of Extracellular Signal-Regulated Kinase Phosphorylation in Zebra Finch Auditory Forebrain during Song Presentation
J. Neurosci., August 25, 2004; 24(34): 7503 - 7513.
[Abstract] [Full Text] [PDF]
X. Chen and D. Johnston
Properties of single voltage-dependent K+ channels in dendrites of CA1 pyramidal neurones of rat hippocampus
J. Physiol., August 15, 2004; 559(1): 187 - 203.
[Abstract] [Full Text] [PDF]
C. Bernard, A. Anderson, A. Becker, N. P. Poolos, H. Beck, and D. Johnston
Acquired Dendritic Channelopathy in Temporal Lobe Epilepsy
Science, July 23, 2004; 305(5683): 532 - 535.
[Abstract] [Full Text] [PDF]
S. G. Birnbaum, A. W. Varga, L.-L. Yuan, A. E. Anderson, J. D. Sweatt, and L. A. Schrader
Structure and Function of Kv4-Family Transient Potassium Channels
Physiol Rev, July 1, 2004; 84(3): 803 - 833.
[Abstract] [Full Text] [PDF]
E. A. Kramar, B. Lin, C.-Y. Lin, A. C. Arai, C. M. Gall, and G. Lynch
A Novel Mechanism for the Facilitation of Theta-Induced Long-Term Potentiation by Brain-Derived Neurotrophic Factor
J. Neurosci., June 2, 2004; 24(22): 5151 - 5161.
[Abstract] [Full Text] [PDF]
E. Takahashi, K. Fukuda, S. Miyoshi, M. Murata, T. Kato, M. Ita, T. Tanabe, and S. Ogawa
Leukemia Inhibitory Factor Activates Cardiac L-Type Ca2+ Channels via Phosphorylation of Serine 1829 in the Rabbit Cav1.2 Subunit
Circ. Res., May 14, 2004; 94(9): 1242 - 1248.
[Abstract] [Full Text] [PDF]
A. W. Varga, L.-L. Yuan, A. E. Anderson, L. A. Schrader, G.-Y. Wu, J. R. Gatchel, D. Johnston, and J. D. Sweatt
Calcium-Calmodulin-Dependent Kinase II Modulates Kv4.2 Channel Expression and Upregulates Neuronal A-Type Potassium Currents
J. Neurosci., April 7, 2004; 24(14): 3643 - 3654.
[Abstract] [Full Text] [PDF]
X. X. Sun, J. J. L. Hodge, Y. Zhou, M. Nguyen, and L. C. Griffith
The eag Potassium Channel Binds and Locally Activates Calcium/Calmodulin-dependent Protein Kinase II
J. Biol. Chem., March 12, 2004; 279(11): 10206 - 10214.
[Abstract] [Full Text] [PDF]
W. Shen, S. Hernandez-Lopez, T. Tkatch, J. E. Held, and D. J. Surmeier
Kv1.2-Containing K+ Channels Regulate Subthreshold Excitability of Striatal Medium Spiny Neurons
J Neurophysiol, March 1, 2004; 91(3): 1337 - 1349.
[Abstract] [Full Text] [PDF]
I. V. Tabarean, M. M. Behrens, T. Bartfai, and H. Korn
Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition
PNAS, February 24, 2004; 101(8): 2590 - 2595.
[Abstract] [Full Text] [PDF]
G. Daoudal and D. Debanne
Long-Term Plasticity of Intrinsic Excitability: Learning Rules and Mechanisms
Learn. Mem., November 1, 2003; 10(6): 456 - 465.
[Abstract] [Full Text] [PDF]
A. Jeromin, L.-L. Yuan, A. Frick, P. Pfaffinger, and D. Johnston
A Modified Sindbis Vector for Prolonged Gene Expression in Neurons
J Neurophysiol, October 1, 2003; 90(4): 2741 - 2745.
[Abstract] [Full Text] [PDF]
C. Bernard and D. Johnston
Distance-Dependent Modifiable Threshold for Action Potential Back-Propagation in Hippocampal Dendrites
J Neurophysiol, September 1, 2003; 90(3): 1807 - 1816.
[Abstract] [Full Text] [PDF]
H.-J. Hu, K. S. Glauner, and R. W. Gereau IV
ERK Integrates PKA and PKC Signaling in Superficial Dorsal Horn Neurons. I. Modulation of A-Type K+ Currents
J Neurophysiol, September 1, 2003; 90(3): 1671 - 1679.
[Abstract] [Full Text] [PDF]
H.-J. Hu and R. W. Gereau IV
ERK Integrates PKA and PKC Signaling in Superficial Dorsal Horn Neurons. II. Modulation of Neuronal Excitability
J Neurophysiol, September 1, 2003; 90(3): 1680 - 1688.
[Abstract] [Full Text] [PDF]
C. A. Hoeffer, S. Sanyal, and M. Ramaswami
Acute Induction of Conserved Synaptic Signaling Pathways in Drosophila Melanogaster
J. Neurosci., July 16, 2003; 23(15): 6362 - 6372.
[Abstract] [Full Text] [PDF]
P. Opazo, A. M. Watabe, S. G. N. Grant, and T. J. O'Dell
Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms
J. Neurosci., May 1, 2003; 23(9): 3679 - 3688.
[Abstract] [Full Text] [PDF]
A. Frick, J. Magee, H. J. Koester, M. Migliore, and D. Johnston
Normalization of Ca2+ Signals by Small Oblique Dendrites of CA1 Pyramidal Neurons
J. Neurosci., April 15, 2003; 23(8): 3243 - 3250.
[Abstract] [Full Text] [PDF]
L. Noonan, B. Doiron, C. Laing, A. Longtin, and R. W. Turner
A Dynamic Dendritic Refractory Period Regulates Burst Discharge in the Electrosensory Lobe of Weakly Electric Fish
J. Neurosci., February 15, 2003; 23(4): 1524 - 1534.
[Abstract] [Full Text] [PDF]
J. C. Selcher, E. J. Weeber, J. Christian, T. Nekrasova, G. E. Landreth, and J. D. Sweatt
A Role for ERK MAP Kinase in Physiologic Temporal Integration in Hippocampal Area CA1
Learn. Mem., January 1, 2003; 10(1): 26 - 39.
[Abstract] [Full Text] [PDF]
L. A. Schrader, A. E. Anderson, A. Mayne, P. J. Pfaffinger, and J. D. Sweatt
PKA Modulation of Kv4.2-Encoded A-Type Potassium Channels Requires Formation of a Supramolecular Complex
J. Neurosci., December 1, 2002; 22(23): 10123 - 10133.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|