QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (57) Citing Articles via Google Scholar Google Scholar Articles by Rodrigues, S. M. Articles by LeDoux, J. E. Search for Related Content PubMed PubMed Citation Articles by Rodrigues, S. M. Articles by LeDoux, J. E.

 Previous Article  |  Next Article 

The Journal of Neuroscience, June 15, 2002, 22(12):5219-5229

The Group I Metabotropic Glutamate Receptor mGluR5 Is Required for Fear Memory Formation and Long-Term Potentiation in the Lateral Amygdala

Sarina M. Rodrigues, Elizabeth P. Bauer, Claudia R. Farb, Glenn E. Schafe, and Joseph E. LeDoux

W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003

The group I metabotropic glutamate receptor subtype mGluR5 has been shown to play a key role in the modulation of synaptic plasticity. The present experiments examined the function of mGluR5 in the circuitry underlying Pavlovian fear conditioning using neuroanatomical, electrophysiological, and behavioral techniques. First, we show using immunocytochemical and tract-tracing methods that mGluR5 is localized to dendritic shafts and spines in the lateral nucleus of the amygdala (LA) and is postsynaptic to auditory thalamic inputs. In electrophysiological experiments, we show that long-term potentiation at thalamic input synapses to the LA is impaired by bath application of a specific mGluR5 antagonist, 2-methyl-6-(phenyle-thynyl)-pyridine (MPEP), in vitro. Finally, we show that intra-amygdala administration of MPEP dose-dependently impairs the acquisition, but not expression or consolidation, of auditory and contextual fear conditioning. Collectively, the results of this study indicate that mGluR5 in the LA plays a crucial role in fear conditioning and in plasticity at synapses involved in fear conditioning.

Key words: mGluR5; fear conditioning; MPEP; LTP; amygdala; plasticity

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/22125219-11$05.00/0

This article has been cited by other articles:

				J. W. Rudy and P. Matus-Amat DHPG activation of group 1 mGluRs in BLA enhances fear conditioning Learn. Mem., June 24, 2009; 16(7): 421 - 425. [Abstract] [Full Text] [PDF]

				J. Xu, Y. Zhu, A. Contractor, and S. F. Heinemann mGluR5 Has a Critical Role in Inhibitory Learning J. Neurosci., March 25, 2009; 29(12): 3676 - 3684. [Abstract] [Full Text] [PDF]

				J. E. Ploski, V. J. Pierre, J. Smucny, K. Park, M. S. Monsey, K. A. Overeem, and G. E. Schafe The Activity-Regulated Cytoskeletal-Associated Protein (Arc/Arg3.1) Is Required for Memory Consolidation of Pavlovian Fear Conditioning in the Lateral Amygdala J. Neurosci., November 19, 2008; 28(47): 12383 - 12395. [Abstract] [Full Text] [PDF]

				J. M. Power and P. Sah Distribution of IP3-mediated calcium responses and their role in nuclear signalling in rat basolateral amygdala neurons J. Physiol., May 1, 2007; 580(3): 835 - 857. [Abstract] [Full Text] [PDF]

				A. E. Dityatev and V. Y. Bolshakov Amygdala, Long-term Potentiation, and Fear Conditioning Neuroscientist, February 1, 2005; 11(1): 75 - 88. [Abstract] [PDF]

				J. M. Power and P. Sah Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials J. Physiol., January 15, 2005; 562(2): 439 - 453. [Abstract] [Full Text] [PDF]

				S. C. Azad, K. Monory, G. Marsicano, B. F. Cravatt, B. Lutz, W. Zieglgansberger, and G. Rammes Circuitry for Associative Plasticity in the Amygdala Involves Endocannabinoid Signaling J. Neurosci., November 3, 2004; 24(44): 9953 - 9961. [Abstract] [Full Text] [PDF]

				M. Wu, T. Hajszan, C. Xu, C. Leranth, and M. Alreja Group I Metabotropic Glutamate Receptor Activation Produces a Direct Excitation of Identified Septohippocampal Cholinergic Neurons J Neurophysiol, August 1, 2004; 92(2): 1216 - 1225. [Abstract] [Full Text] [PDF]

				S. M. Rodrigues, C. R. Farb, E. P. Bauer, J. E. LeDoux, and G. E. Schafe Pavlovian Fear Conditioning Regulates Thr286 Autophosphorylation of Ca2+/Calmodulin-Dependent Protein Kinase II at Lateral Amygdala Synapses J. Neurosci., March 31, 2004; 24(13): 3281 - 3288. [Abstract] [Full Text] [PDF]

				G. Battaglia, C. L. Busceti, G. Molinaro, F. Biagioni, M. Storto, F. Fornai, F. Nicoletti, and V. Bruno Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Contributes to the Development of Nigro-Striatal Damage Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice J. Neurosci., January 28, 2004; 24(4): 828 - 835. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help