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The Journal of Neuroscience, July 1, 2002, 22(13):5259-5264
BRIEF COMMUNICATION
Retinogeniculate Axons Undergo Eye-Specific Segregation in the
Absence of Eye-Specific Layers
Gianna
Muir-Robinson1,
Bryan J.
Hwang2, and
Marla
B.
Feller1
1 Neurobiology Section, Biology Division, University of
California San Diego, La Jolla, California 92093, and
2 Howard Hughes Medical Institute-National
Institutes of Health Research Scholars Program, Bethesda, Maryland
20892
Spontaneous retinal activity mediated by cholinergic
transmission regulates the segregation of retinal ganglion cell axons in the lateral geniculate nucleus of the thalamus into
eye-specific layers. The details of how the layers form are unknown.
Mice lacking the  2 subunit of the neuronal nicotinic acetylcholine
receptor lack ACh-mediated waves and as a result, do not form
eye-specific layers at any stage of development. However, during the
second postnatal week, 2 / mice have glutamate-mediated waves.
Here we show that after the first postnatal week, even in the absence of layers, retinothalamic axons segregate into an unlayered, patchy distribution of eye-specific regions. These results indicate that spontaneous neural activity may independently regulate eye-specific segregation and the formation of layers at the developing
retinothalamic projection.
Key words:
retinogeniculate segregation; retinal waves; spontaneous
activity; visual-system development; eye-specific layers; nicotinic
receptor subunits
Copyright © 2002 Society for Neuroscience 0270-6474/02/22135259-06$05.00/0
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