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The Journal of Neuroscience, July 1, 2002, 22(13):5259-5264

BRIEF COMMUNICATION
Retinogeniculate Axons Undergo Eye-Specific Segregation in the Absence of Eye-Specific Layers

Gianna Muir-Robinson¹, Bryan J. Hwang², and Marla B. Feller¹

¹ Neurobiology Section, Biology Division, University of California San Diego, La Jolla, California 92093, and ² Howard Hughes Medical Institute-National Institutes of Health Research Scholars Program, Bethesda, Maryland 20892

Spontaneous retinal activity mediated by cholinergic transmission regulates the segregation of retinal ganglion cell axons in the lateral geniculate nucleus of the thalamus into eye-specific layers. The details of how the layers form are unknown. Mice lacking the 2 subunit of the neuronal nicotinic acetylcholine receptor lack ACh-mediated waves and as a result, do not form eye-specific layers at any stage of development. However, during the second postnatal week, 2/ mice have glutamate-mediated waves. Here we show that after the first postnatal week, even in the absence of layers, retinothalamic axons segregate into an unlayered, patchy distribution of eye-specific regions. These results indicate that spontaneous neural activity may independently regulate eye-specific segregation and the formation of layers at the developing retinothalamic projection.

Key words: retinogeniculate segregation; retinal waves; spontaneous activity; visual-system development; eye-specific layers; nicotinic receptor subunits

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22135259-06$05.00/0

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