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The Journal of Neuroscience, July 1, 2002, 22(13):5516-5524

The Role of gp130 in Cerebral Cortical Development: In Vivo Functional Analysis in a Mouse Exo Utero System

Toshihisa Hatta¹, Kenji Moriyama¹, Kinichi Nakashima², Tetsuya Taga², and Hiroki Otani¹

¹ Department of Anatomy, Shimane Medical University, Izumo 693-8501, Japan, and ² Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan

The role of gp130 in cerebral cortical histogenesis remains unknown. Mice lacking gp130 showed a hypoplastic cortical plate and decreased incorporation of 5-bromo-2'-deoxyuridine (BrdU) in progenitor cells of the developing cerebrum. In contrast, injection of leukemia inhibitory factor (LIF), a gp130 ligand, into the lateral cerebral ventricle of wild-type embryos exo utero induced hyperplasia of the cerebral cortex and increased the incorporation of BrdU in progenitor cells. Furthermore, chronologically controlled injection of LIF followed or preceded by BrdU revealed that gp130-mediated signals promote the progenitor cells to reenter the stem cell cycle without affecting the duration of cell cycle and enhance the migration of postmitotic neurons in the developing cerebrum.

Key words: gp130; leukemia inhibitory factor; cerebral cortex; neurogenesis; exo utero development; knock-out mouse

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22135516-09$05.00/0

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