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Previous Article | Next Article
The Journal of Neuroscience, July 1, 2002, 22(13):5552-5562
Spontaneous Unitary Synaptic Activity in CA1 Pyramidal Neurons during Early Postnatal Development: Constant Contribution of AMPA and NMDA Receptors
Laurent Groc, Bengt Gustafsson, and Eric Hanse Institute of Physiology and Pharmacology, Department of Physiology, Göteborg University, 405 30 Göteborg, Sweden
Maturation of the glutamatergic synapse is thought to require the incorporation of AMPA receptors at pure NMDA synapses, also called "silent" synapses. However, the relative number of silent synapses at different developmental stages, and even the concept that silent synapses lack AMPA receptors, is actively debated. In the present work, spontaneous synaptic events were used to investigate the relative contribution of synaptic AMPA and NMDA receptor-mediated transmission in CA1 pyramidal cells during the early postnatal development. Spontaneous postsynaptic currents, mediated by AMPA and NMDA receptors, were recorded from visualized CA1 pyramidal neurons over the first postnatal week. AMPA/NMDA ratio for frequency was close to one, and, importantly, it was constant over the first postnatal week. These findings suggest that the vast majority of nascent glutamatergic synapses express both functional AMPA and NMDA receptors in the neonatal hippocampus.
Key words: AMPA receptor; NMDA receptor; neonate hippocampus; silent synapse; development; spontaneous activity
Copyright © 2002 Society for Neuroscience 0270-6474/02/22135552-11$05.00/0
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