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The Journal of Neuroscience, July 15, 2002, 22(14):5931-5937

Stomatin-Related Olfactory Protein, SRO, Specifically Expressed in the Murine Olfactory Sensory Neurons

Ko Kobayakawa, Reiko Hayashi, Kenji Morita, Kazunari Miyamichi, Yuichiro Oka, Akio Tsuboi, and Hitoshi Sakano

Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan

We identified a stomatin-related olfactory protein (SRO) that is specifically expressed in olfactory sensory neurons (OSNs). The mouse sro gene encodes a polypeptide of 287 amino acids with a calculated molecular weight of 32 kDa. SRO shares 82% sequence similarity with the murine stomatin, 78% with Caenorhabditis elegans MEC-2, and 77% with C. elegans UNC-1. Unlike other stomatin-family genes, the sro transcript was present only in OSNs of the main olfactory epithelium. No sro expression was seen in vomeronasal neurons. SRO was abundant in most apical dendrites of OSNs, including olfactory cilia. Immunoprecipitation revealed that SRO associates with adenylyl cyclase type III and caveolin-1 in the low-density membrane fraction of olfactory cilia. Furthermore, anti-SRO antibodies stimulated cAMP production in fractionated cilia membrane. SRO may play a crucial role in modulating odorant signals in the lipid rafts of olfactory cilia.

Key words: olfactory sensory neuron; olfactory cilia; stomatin; MEC-2; lipid rafts; adenylyl cyclase; caveolin

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22145931-07$05.00/0

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