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The Journal of Neuroscience, July 15, 2002, 22(14):6029-6040
A Critical Function of the Pial Basement Membrane in Cortical Histogenesis
Willi Halfter1, Sucai Dong1, Yi-Ping Yip1, Michael Willem2, and Ulrike Mayer2, 3 1 Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, 2 Max Planck Institute for Biochemistry, D-82152 Planegg-Martinsried, Germany, and 3 University of Manchester, Wellcome Trust Centre for Cell-Matrix Research, Manchester M13 9PT, United Kingdom
Mice with a targeted deletion of the nidogen-binding site of laminin
1 were used to study the function of the pial basement membrane in cortical histogenesis. The pial basement membrane in the mutant embryos assembled but was unstable and disintegrated at random segments. In segments with a disrupted basement membrane, radial glia cells were retracted from the pial surface, and radially migrating neurons, including Cajal-Retzius cells and cortical plate neurons, passed the meninges or terminated their migration prematurely. By correlating the disruptions in the pial basal lamina with changes in the morphology of radial glia cells, the aberrant migration of Cajal-Retzius cells, and subsequent dysplasia of cortical plate neurons, the present data establish a causal relationship of proper cortical histogenesis with the presence of an intact pial basement membrane.
Key words: basement membrane; laminin; cortical dysplasia; Cajal-Retzius cells; nidogen; radial glia cells
Copyright © 2002 Society for Neuroscience 0270-6474/02/22146029-12$05.00/0
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