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The Journal of Neuroscience, July 15, 2002, 22(14):6158-6175
Space and Time Maps of Cone Photoreceptor Signals in Macaque
Lateral Geniculate Nucleus
R. Clay
Reid1, 2 and
Robert M.
Shapley1
1 Center for Neural Science, New York University, New
York, New York 10003, and 2 Department of Neurobiology,
Harvard Medical School, Boston, Massachusetts 02115
We studied neurons in the central visual field representation of
the lateral geniculate nucleus (LGN) in macaque monkeys by mapping
their receptive fields in space and time. The mapping was performed by
reverse correlation of a spike train of a neuron with pseudorandom,
binary level stimuli (m-sequence grids). Black and white m-sequence
grids were used to map the receptive field for luminance. The locations
of receptive field center and surround were determined from this
luminance map. To map the contribution of each cone class to the
receptive field, we designed red-green or blue-yellow
m-sequence grids to isolate the influence of that cone (long, middle,
or short wavelength-sensitive: L, M, or S). Magnocellular neurons
generally received synergistic input from L and M cones in both the
center and the surround. A minority had cone-antagonistic (M-L) input
to the surround. Red-green opponent parvocellular neurons received
opponent cone input (L+M or M+L) that overlapped in space, as
sampled by our stimulus grid, but that had somewhat different extents.
For example, an L+ center parvocellular neuron would be L+/M in both
center and surround, but the L+ signal would be stronger in the center
and the M signal stronger in the surround. Accordingly, the luminance
receptive field would be spatially antagonistic:
on-center/off-surround. The space-time maps also characterized
LGN dynamics. For example, magnocellular responses were transient,
red-green parvocellular responses were more sustained, and blue-on
responses were the most sustained for both luminance and cone-isolating
stimuli. For all cell types the surround response peaked 8-10 msec
later than the center response.
Key words:
receptive field; primate; color; LGN; lateral geniculate; retina; dynamics; cone photoreceptor; m-sequence
Copyright © 2002 Society for Neuroscience 0270-6474/02/22146158-18$05.00/0
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