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The Journal of Neuroscience, August 1, 2002, 22(15):6309-6314
BRIEF COMMUNICATION
Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing LineageJessica A. Gorski1, Tiffany Talley1, Mengsheng Qiu3, Luis Puelles4, John L. R. Rubenstein2, and Kevin R. Jones1 1 Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, 2 Department of Psychiatry, University of California at San Francisco, San Francisco, California 94143-0984, 3 Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky 40241, and 4 Department of Morphological Sciences, Medical School, University of Murcia, E30100 Murcia, Spain
By homologous recombination of an internal ribosome entry site and Cre recombinase coding region into the 3'-untranslated region of the mouse Emx1 gene, we have generated a strain of mice, Emx1IREScre, that expresses the Cre recombinase in a spatial and temporal pattern like that observed for Emx1. When mated to reporter strains, these mice are a sensitive means to fate-map the Emx1-expressing cells of the developing forebrain. Our results demonstrate that radial glia, Cajal-Retzius cells, glutamatergic neurons, astrocytes, and oligodendrocytes of most pallial structures originate from an Emx1-expressing lineage. On the other hand, most of the pallial GABAergic neurons arise outside the Emx1-expressing lineage. Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells.
Key words: Emx1; cell fate; cortex; hippocampus; Cre; GABAergic interneuron; glia
Copyright © 2002 Society for Neuroscience 0270-6474/02/22156309-06$05.00/0
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