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The Journal of Neuroscience, August 1, 2002, 22(15):6321-6324

BRIEF COMMUNICATION
Caffeine Induces Dopamine and Glutamate Release in the Shell of the Nucleus Accumbens

Marcello Solinas¹, Sergi Ferré¹, Zhi-Bing You², Marzena Karcz-Kubicha¹, Patrizia Popoli³, and Steven R. Goldberg¹

Sections of ¹ Preclinical Pharmacology and ² Behavioral Neuroscience, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health Intramural Research Program, Baltimore, Maryland 21224, and ³ Department of Pharmacology, Istituto Superiore di Sanita, 00161 Rome, Italy

An increase in the extracellular concentration of dopamine in the nucleus accumbens (NAc) is believed to be one of the main mechanisms involved in the rewarding and motor-activating properties of psychostimulants such as amphetamines and cocaine. Using in vivo microdialysis in freely moving rats, we demonstrate that systemic administration of behaviorally relevant doses of caffeine can preferentially increase extracellular levels of dopamine and glutamate in the shell of the NAc. These effects could be reproduced by the administration of a selective adenosine A1 receptor antagonist but not by a selective adenosine A2A receptor antagonist. This suggests that caffeine, because of its ability to block adenosine A1 receptors, shares neurochemical properties with other psychostimulants, which could contribute to the widespread consumption of caffeine-containing beverages.

Key words: caffeine; adenosine; dopamine; glutamate; accumbens; microdialysis

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22156321-04$05.00/0

This article has been cited by other articles:

				F. Ciruela, V. Casado, R. J. Rodrigues, R. Lujan, J. Burgueno, M. Canals, J. Borycz, N. Rebola, S. R. Goldberg, J. Mallol, et al. Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1-A2A Receptor Heteromers J. Neurosci., February 15, 2006; 26(7): 2080 - 2087. [Abstract] [Full Text] [PDF]

				Z. Justinova, S. Ferre, P. N. Segal, K. Antoniou, M. Solinas, L. A. Pappas, J. L. Highkin, J. Hockemeyer, P. Munzar, and S. R. Goldberg Involvement of Adenosine A1 and A2A Receptors in the Adenosinergic Modulation of the Discriminative-Stimulus Effects of Cocaine and Methamphetamine in Rats J. Pharmacol. Exp. Ther., December 1, 2003; 307(3): 977 - 986. [Abstract] [Full Text] [PDF]

				E. Bastia and M. A. Schwarzschild DARPP Chocolate: A Caffeinated Morsel of Striatal Signaling Sci. Signal., January 14, 2003; 2003(165): pe2 - pe2. [Abstract] [Full Text] [PDF]

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