WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (55)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schuett, S.
Right arrow Articles by Hübener, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schuett, S.
Right arrow Articles by Hübener, M.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*Diagnostic Imaging

 Previous Article  |  Next Article 

The Journal of Neuroscience, August 1, 2002, 22(15):6549-6559

Mapping Retinotopic Structure in Mouse Visual Cortex with Optical Imaging

Sven Schuett, Tobias Bonhoeffer, and Mark Hübener

Max-Planck-Institut für Neurobiologie, D-82152 Martinsried, Germany

We have used optical imaging of intrinsic signals to visualize the retinotopic organization of mouse visual cortex. The functionally determined position, size, and shape of area 17 corresponded precisely to the location of this area as seen in stained cortical sections. The retinotopic map, which was confirmed with electrophysiological recordings, exhibited very low inter-animal variability, thus allowing averaging of maps across animals. Patches of activity in area 17 were often encircled by regions in which the intrinsic signal dropped below baseline, suggesting the presence of strong surround inhibition. Single-unit recordings revealed that this decrease of the intrinsic signal indeed correlated with a drop of neuronal firing rate below baseline. The averaged maps also greatly facilitated the identification of extrastriate visual activity, pointing to at least four extrastriate visual areas in the mouse. We conclude that optical imaging is ideally suited to visualize retinotopic maps in mice, thus making this a powerful technique for the analysis of map structure in transgenic animals.

Key words: visual cortex; optical imaging; brain mapping; retinotopy; map formation; cortical magnification factor; lateral inhibition; mice

Copyright © 2002 Society for Neuroscience  0270-6474/02/22156549-11$05.00/0


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
J. Cang, L. Wang, M. P. Stryker, and D. A. Feldheim
Roles of Ephrin-As and Structured Activity in the Development of Functional Maps in the Superior Colliculus
J. Neurosci., October 22, 2008; 28(43): 11015 - 11023.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
E. Van der Gucht, P. R. Hof, L. Van Brussel, K. Burnat, and L. Arckens
Neurofilament Protein and Neuronal Activity Markers Define Regional Architectonic Parcellation in the Mouse Visual Cortex
Cereb Cortex, December 1, 2007; 17(12): 2805 - 2819.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. R. Husson, A. K. Mallik, J. X. Zhang, and N. P. Issa
Functional Imaging of Primary Visual Cortex Using Flavoprotein Autofluorescence
J. Neurosci., August 8, 2007; 27(32): 8665 - 8675.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Tohmi, H. Kitaura, S. Komagata, M. Kudoh, and K. Shibuki
Enduring critical period plasticity visualized by transcranial flavoprotein imaging in mouse primary visual cortex.
J. Neurosci., November 8, 2006; 26(45): 11775 - 11785.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. D. Mrsic-Flogel, S. B. Hofer, C. Creutzfeldt, I. Cloez-Tayarani, J.-P. Changeux, T. Bonhoeffer, and M. Hubener
Altered Map of Visual Space in the Superior Colliculus of Mice Lacking Early Retinal Waves
J. Neurosci., July 20, 2005; 25(29): 6921 - 6928.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. D. Van Hooser, J. A. F. Heimel, S. Chung, S. B. Nelson, and L. J. Toth
Orientation Selectivity without Orientation Maps in Visual Cortex of a Highly Visual Mammal
J. Neurosci., January 5, 2005; 25(1): 19 - 28.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Suh, S. Bahar, A. D. Mehta, and T. H. Schwartz
Temporal Dependence in Uncoupling of Blood Volume and Oxygenation during Interictal Epileptiform Events in Rat Neocortex
J. Neurosci., January 5, 2005; 25(1): 68 - 77.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Carreira-Perpinan and G. J. Goodhill
Influence of Lateral Connections on the Structure of Cortical Maps
J Neurophysiol, November 1, 2004; 92(5): 2947 - 2959.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. S. Grubb and I. D. Thompson
Quantitative Characterization of Visual Response Properties in the Mouse Dorsal Lateral Geniculate Nucleus
J Neurophysiol, December 1, 2003; 90(6): 3594 - 3607.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. C. Lyon, X. Xu, V. A. Casagrande, J. D. Stefansic, D. Shima, and J. H. Kaas
Inaugural Article: Optical imaging reveals retinotopic organization of dorsal V3 in New World owl monkeys
PNAS, November 26, 2002; 99(24): 15735 - 15742.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-