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The Journal of Neuroscience, August 1, 2002, 22(15):6800-6809
Modular Organization of Turtle Spinal Interneurons during Normal and Deletion Fictive Rostral Scratching
Paul S. G. Stein and Susan Daniels-McQueen Department of Biology, Washington University, St. Louis, Missouri 63130
During normal rostral scratching in the spinal turtle, there is rhythmic alternation between hip-flexor and hip-extensor motor activity. During rostral scratching with hip-extensor deletions, there are successive bursts of hip-flexor motor activity and no activity in hip-extensor motor neurons. We characterized the ON- and OFF-phases of 72 descending propriospinal interneurons with distinct activity bursts during normal rostral scratching. We also studied the activity of these interneurons during deletion scratching. Hip-extensor interneurons were active when hip-flexor motor neurons were quiet in normal scratching and had zero overlap with hip-flexor motor activity. This population of hip-extensor interneurons, termed the hip-extensor module or hip-extensor unit-burst generator, was mainly quiet during deletion scratching. Our observation supports the concept that a module is a neuronal population that may be active or quiet in a coordinated manner during a spinal motor rhythm. During normal scratching, hip-flexor interneurons were active during hip-flexor motor activity, and spanning interneurons were active during both hip-flexor motor activity and quiescence. Hip-flexor and spanning interneurons with intermediate overlap with hip-flexor motor activity fired in bursts during deletion scratching. Hip-flexor and spanning interneurons with large overlap with hip-flexor motor activity fired continuously during deletion scratching. Key features of hip-flexor and spanning interneuron firing during normal scratching were preserved during deletion scratching. Thus these features do not require activity in the hip-extensor module in every cycle of a motor rhythm.
Key words: spinal cord; scratch reflex; half-center; central pattern generator; turtle; reciprocal inhibition; fictive motor patterns
Copyright © 2002 Society for Neuroscience 0270-6474/02/22156800-10$05.00/0
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