 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, August 15, 2002, 22(16):6842-6845
BRIEF COMMUNICATION
Spontaneous versus Reinforced Olfactory DiscriminationsChristiane Linster1, Brett A. Johnson2, Alix Morse1, Esther Yue1, and Michael Leon2 1 Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, and 2 Department of Neurobiology and Behavior, University of California, Irvine, California 92697-4550
When the major response domains in the rat olfactory bulb that are evoked by odorant enantiomers are compared, some of these odorant pairs do not show significantly different activity patterns. Such pairs are not spontaneously discriminated in a behavioral test. We show here that even these similar odorants appear to evoke different activity patterns when every data point in a glomerular activity array is compared. These odorants also can be discriminated if they are subjected to differential reinforcement. These data suggest that the method chosen to assess olfactory discrimination will reveal different olfactory capabilities of rats. The small differences in glomerular activity that probably exist between any pair of odorants may serve as a basis for odor discrimination when rats are differentially reinforced, thereby establishing the remarkable limits of rat olfactory perception. At the same time, the major differences in glomerular responses appear to serve as the normal basis for spontaneous odor discrimination.
Key words: olfactory coding; enantiomers; optical isomers; odor perception; neural representations; habituation; reinforcement learning; olfactory bulb; glomeruli
Copyright © 2002 Society for Neuroscience 0270-6474/02/22166842-04$05.00/0
This article has been cited by other articles:
K. G. Bath, N. Mandairon, D. Jing, R. Rajagopal, R. Kapoor, Z.-Y. Chen, T. Khan, C. C. Proenca, R. Kraemer, T. A. Cleland, et al.
Variant Brain-Derived Neurotrophic Factor (Val66Met) Alters Adult Olfactory Bulb Neurogenesis and Spontaneous Olfactory Discrimination
J. Neurosci., March 5, 2008; 28(10): 2383 - 2393.
[Abstract] [Full Text] [PDF]
E. K. Mwilaria, C. Ghatak, and K. C. Daly
Disruption of GABAA in the Insect Antennal Lobe Generally Increases Odor Detection and Discrimination Thresholds
Chem Senses, March 1, 2008; 33(3): 267 - 281.
[Abstract] [Full Text] [PDF]
A. M. McNamara, P. D. Magidson, C. Linster, D. A. Wilson, and T. A. Cleland
Distinct neural mechanisms mediate olfactory memory formation at different timescales
Learn. Mem., February 22, 2008; 15(3): 117 - 125.
[Abstract] [Full Text] [PDF]
J. A. GOTTFRIED
What Can an Orbitofrontal Cortex-Endowed Animal Do with Smells?
Ann. N.Y. Acad. Sci., December 1, 2007; 1121(1): 102 - 120.
[Abstract] [Full Text] [PDF]
B. Slotnick
Response Accuracy and Odor Sampling Time in Mice Trained to Discriminate between Enantiomers of Carvone and Those of Terpinen-4-ol
Chem Senses, September 1, 2007; 32(7): 721 - 725.
[Abstract] [Full Text] [PDF]
W. Doucette, J. Milder, and D. Restrepo
Adrenergic modulation of olfactory bulb circuitry affects odor discrimination
Learn. Mem., August 3, 2007; 14(8): 539 - 547.
[Abstract] [Full Text] [PDF]
T. A. Cleland, B. A. Johnson, M. Leon, and C. Linster
Relational representation in the olfactory system
PNAS, February 6, 2007; 104(6): 1953 - 1958.
[Abstract] [Full Text] [PDF]
B. Slotnick
Olfactory Performance of Rats after Selective Deafferentation of the Olfactory Bulb by 3-Methyl Indole
Chem Senses, February 1, 2007; 32(2): 173 - 181.
[Abstract] [Full Text] [PDF]
M. Alonso, C. Viollet, M.-M. Gabellec, V. Meas-Yedid, J.-C. Olivo-Marin, and P.-M. Lledo
Olfactory Discrimination Learning Increases the Survival of Adult-Born Neurons in the Olfactory Bulb
J. Neurosci., October 11, 2006; 26(41): 10508 - 10513.
[Abstract] [Full Text] [PDF]
K. McBride and B. Slotnick
Discrimination between the Enantiomers of Carvone and of Terpinen-4-ol Odorants in Normal Rats and Those with Lesions of the Olfactory Bulbs
J. Neurosci., September 27, 2006; 26(39): 9892 - 9901.
[Abstract] [Full Text] [PDF]
N. Mandairon, C. Stack, C. Kiselycznyk, and C. Linster
Broad activation of the olfactory bulb produces long-lasting changes in odor perception
PNAS, September 5, 2006; 103(36): 13543 - 13548.
[Abstract] [Full Text] [PDF]
D. Joshi, M. Volkl, G. M. Shepherd, and M. Laska
Olfactory Sensitivity for Enantiomers and Their Racemic Mixtures--A Comparative Study in CD-1 Mice and Spider Monkeys
Chem Senses, September 1, 2006; 31(7): 655 - 664.
[Abstract] [Full Text] [PDF]
C. L. Kiselycznyk, S. Zhang, and C. Linster
Role of centrifugal projections to the olfactory bulb in olfactory processing
Learn. Mem., September 1, 2006; 13(5): 575 - 579.
[Abstract] [Full Text] [PDF]
T. A. Cleland and C. Linster
Computation in the Olfactory System
Chem Senses, November 1, 2005; 30(9): 801 - 813.
[Abstract] [Full Text] [PDF]
D. A. Wilson, A. R. Best, and R. M. Sullivan
Plasticity in the Olfactory System: Lessons for the Neurobiology of Memory
Neuroscientist, December 1, 2004; 10(6): 513 - 524.
[Abstract] [PDF]
C. E. Reisenman, T. A. Christensen, W. Francke, and J. G. Hildebrand
Enantioselectivity of Projection Neurons Innervating Identified Olfactory Glomeruli
J. Neurosci., March 17, 2004; 24(11): 2602 - 2611.
[Abstract] [Full Text] [PDF]
G. A. Wright and B. H. Smith
Different Thresholds for Detection and Discrimination of Odors in the Honey bee (Apis mellifera)
Chem Senses, February 1, 2004; 29(2): 127 - 135.
[Abstract] [Full Text] [PDF]
D. A. Wilson, M. L. Fletcher, and R. M. Sullivan
Acetylcholine and Olfactory Perceptual Learning
Learn. Mem., January 1, 2004; 11(1): 28 - 34.
[Abstract] [Full Text] [PDF]
M. Ditzen, J.-F. Evers, and C. G. Galizia
Odor Similarity Does Not Influence the Time Needed for Odor Processing
Chem Senses, November 1, 2003; 28(9): 781 - 789.
[Abstract] [Full Text] [PDF]
D. A. Wilson
Rapid, Experience-Induced Enhancement in Odorant Discrimination by Anterior Piriform Cortex Neurons
J Neurophysiol, July 1, 2003; 90(1): 65 - 72.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|