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The Journal of Neuroscience, August 15, 2002, 22(16):7297-7307

Decreased Neuronal Synchronization during Experimental Seizures

Theoden I. Netoff^{1, 3} and Steven J. Schiff^{1, 2, 3}

¹ Krasnow Institute for Advanced Studies and ² Department of Psychology, George Mason University, Fairfax, Virginia, 22030, and ³ Neuroscience Program, The George Washington University, Washington, DC 20037

Synchronization between CA1 pyramidal neurons was studied using dual-cell patch-clamp techniques simultaneous with an extracellular measurement of network activity. We explored various linear and nonlinear methods to detect weak synchronization in this network, using cross-correlation, mutual information in one and two dimensions, and phase correlation in both broad and narrow band. The linear and nonlinear methods demonstrated different patterns of sensitivity to detect synchrony in this network, depending on the dynamical state of the network. Bursts in 4-amino-pyridine (4AP) were highly synchronous events. Unexpectedly, seizure-like events in 4AP were desynchronous events, both in comparison with interictal periods preceding the seizure without bursts (cut Schaffer collateral tract) and in comparison with bursts preceding the seizures (intact Schaffer collateral tract). The finding that seizure-like events are associated with desynchronization in such networks is consistent with recent theoretical work, suggesting that asynchrony is necessary to maintain a high level of activity in neuronal networks for sustained periods of time and that synchrony may disrupt such activity.

Key words: seizures; bursts; synchrony; correlation; phase; mutual information; potassium; 4-amino-pyridine

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22167297-11$05.00/0

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