WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (19)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Küry, P.
Right arrow Articles by Müller, H. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Küry, P.
Right arrow Articles by Müller, H. W.

 Previous Article  |  Next Article 

The Journal of Neuroscience, September 1, 2002, 22(17):7586-7595

Mammalian Achaete Scute Homolog 2 Is Expressed in the Adult Sciatic Nerve and Regulates the Expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann Cells

Patrick Küry, Regine Greiner-Petter, Christiane Cornely, Tim Jürgens, and Hans Werner Müller

Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine University of Düsseldorf, D-40225 Düsseldorf, Germany

The molecular control mechanisms and regulatory molecules involved in nerve repair are not yet well known. Schwann cells have been attributed an important role in peripheral nerve regeneration; therefore, attention has been drawn to regulatory factors expressed by these glial cells. Here, we demonstrate that Mash2, a basic helix-loop-helix (bHLH) transcription factor previously shown to be crucial for placenta development, is expressed by Schwann cells of adult peripheral nerves. We observed that this gene is downregulated after nerve lesion and, using cDNA array hybridization technology, we could demonstrate that Mash2 is a regulator of Krox24, Mob-1, and CXCR4 expression in cultured Schwann cells. In addition, we provide strong evidence that Mash2 is a negative regulator of Schwann cell proliferation. Mash2 represents a first candidate for the missing class B bHLH proteins in peripheral nerves.

Key words: basic helix-loop-helix; Schwann cell; cDNA array hybridization; Wallerian degeneration; proliferation; cytokine

Copyright © 2002 Society for Neuroscience  0270-6474/02/22177586-10$05.00/0


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Heinen, D. Kremer, P. Gottle, F. Kruse, B. Hasse, H. Lehmann, H. P. Hartung, and P. Kury
The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination
PNAS, June 24, 2008; 105(25): 8748 - 8753.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
A. Thurston, J. Taylor, J. Gardner, K. D Sinclair, and L. E Young
Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage
Reproduction, January 1, 2008; 135(1): 29 - 40.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. B. D. Alonso, G. Zoidl, C. Taveggia, F. Bosse, C. Zoidl, M. Rahman, E. Parmantier, C. H. Dean, B. S. Harris, L. Wrabetz, et al.
Identification and Characterization of ZFP-57, a Novel Zinc Finger Transcription Factor in the Mammalian Peripheral Nervous System
J. Biol. Chem., June 11, 2004; 279(24): 25653 - 25664.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-