 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, September 1, 2002, 22(17):7639-7649
Local and Target-Derived Brain-Derived Neurotrophic Factor Exert Opposing Effects on the Dendritic Arborization of Retinal Ganglion Cells In Vivo
Barbara Lom1, 2, Jeffrey Cogen1, Analiza Lontok Sanchez1, Thuy Vu1, and Susana Cohen-Cory1 1 Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, and 2 Department of Biology and Program in Neuroscience, Davidson College, Davidson, North Carolina 28035-7118
The dendritic and axonal arbors of developing retinal ganglion cells (RGCs) are exposed to two sources of BDNF: RGC dendrites are exposed to BDNF locally within the retina, and RGC axons are exposed to BDNF at the target, the optic tectum. Our previous studies demonstrated that increasing tectal BDNF levels promotes RGC axon terminal arborization, whereas increasing retinal BDNF levels inhibits RGC dendritic arborization. These results suggested that differential neurotrophic action at the axon versus dendrite might be responsible for the opposing effects of BDNF on RGC axonal versus dendritic arborization. To explore this possibility, we examined the effects of altering BDNF levels at the optic tectum on the elaboration of RGC dendritic arbors in the retina. Increasing tectal BDNF levels resulted in a significant increase in dendritic branching, whereas neutralizing endogenous tectal BDNF with function-blocking antibodies significantly decreased dendritic arbor complexity. Thus, RGC dendritic arbors react in opposing manners to retinal- versus tectal-derived BDNF. Alterations in retinal BDNF levels, however, did not affect axon terminal arborization. Thus, RGC dendritic arborization is controlled in a complementary manner by both local and target-derived sources of BDNF, whereas axon arborization is modulated solely by neurotrophic interactions at the target. Together, our results indicate that developing RGCs modulate dendritic arborization by integrating signals from discrete sources of BDNF in the eye and brain. Differential integration of spatially discrete neurotrophin signals within a single neuron may therefore finely tune afferent and efferent neuronal connectivity.
Key words: brain-derived neurotrophic factor; retinal ganglion cell; retina; dendrite; arborization; Xenopus laevis; visual system development; neurotrophin
Copyright © 2002 Society for Neuroscience 0270-6474/02/22177639-11$05.00/0
This article has been cited by other articles:
J.-l. Du, H.-p. Wei, Z.-r. Wang, S. T. Wong, and M.-m. Poo
Inaugural Articles: Long-range retrograde spread of LTP and LTD from optic tectum to retina
PNAS, November 10, 2009; 106(45): 18890 - 18896.
[Abstract] [Full Text] [PDF]
S. Landi, F. Ciucci, L. Maffei, N. Berardi, and M. C. Cenni
Setting the Pace for Retinal Development: Environmental Enrichment Acts Through Insulin-Like Growth Factor 1 and Brain-Derived Neurotrophic Factor
J. Neurosci., September 2, 2009; 29(35): 10809 - 10819.
[Abstract] [Full Text] [PDF]
M. F. Pazyra-Murphy, A. Hans, S. L. Courchesne, C. Karch, K. E. Cosker, H. M. Heerssen, F. L. Watson, T. Kim, M. E. Greenberg, and R. A. Segal
A Retrograde Neuronal Survival Response: Target-Derived Neurotrophins Regulate MEF2D and bcl-w
J. Neurosci., May 20, 2009; 29(20): 6700 - 6709.
[Abstract] [Full Text] [PDF]
M. A. Raven, E. C. T. Oh, A. Swaroop, and B. E. Reese
Afferent Control of Horizontal Cell Morphology Revealed by Genetic Respecification of Rods and Cones
J. Neurosci., March 28, 2007; 27(13): 3540 - 3547.
[Abstract] [Full Text] [PDF]
S. Landi, A. Sale, N. Berardi, A. Viegi, L. Maffei, and M. C. Cenni
Retinal functional development is sensitive to environmental enrichment: a role for BDNF
FASEB J, January 1, 2007; 21(1): 130 - 139.
[Abstract] [Full Text] [PDF]
A. L. Sanchez, B. J. Matthews, M. M. Meynard, B. Hu, S. Javed, and S. Cohen-Cory
BDNF increases synapse density in dendrites of developing tectal neurons in vivo
Development, July 1, 2006; 133(13): 2477 - 2486.
[Abstract] [Full Text] [PDF]
B. E. Reese, M. A. Raven, and S. B. Stagg
Afferents and Homotypic Neighbors Regulate Horizontal Cell Morphology, Connectivity, and Retinal Coverage
J. Neurosci., March 2, 2005; 25(9): 2167 - 2175.
[Abstract] [Full Text] [PDF]
R. Molteni, J.-Q. Zheng, Z. Ying, F. Gomez-Pinilla, and J. L. Twiss
Voluntary exercise increases axonal regeneration from sensory neurons
PNAS, June 1, 2004; 101(22): 8473 - 8478.
[Abstract] [Full Text] [PDF]
I.-J. Kim, K. M. Drahushuk, W.-Y. Kim, E. A. Gonsiorek, P. Lein, D. A. Andres, and D. Higgins
Extracellular Signal-Regulated Kinases Regulate Dendritic Growth in Rat Sympathetic Neurons
J. Neurosci., March 31, 2004; 24(13): 3304 - 3312.
[Abstract] [Full Text] [PDF]
S. He, W. Dong, Q. Deng, S. Weng, and W. Sun
Seeing More Clearly: Recent Advances in Understanding Retinal Circuitry
Science, October 17, 2003; 302(5644): 408 - 411.
[Abstract] [Full Text] [PDF]
M. Garcia, V. Forster, D. Hicks, and E. Vecino
In Vivo Expression of Neurotrophins and Neurotrophin Receptors Is Conserved in Adult Porcine Retina In Vitro
Invest. Ophthalmol. Vis. Sci., October 1, 2003; 44(10): 4532 - 4541.
[Abstract] [Full Text] [PDF]
D. Tropea, M. Caleo, and L. Maffei
Synergistic Effects of Brain-Derived Neurotrophic Factor and Chondroitinase ABC on Retinal Fiber Sprouting after Denervation of the Superior Colliculus in Adult Rats
J. Neurosci., August 6, 2003; 23(18): 7034 - 7044.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|